In vivo photoacoustic imaging of blood vessels using an extreme-narrow aperture sensor

Kolkman, R.G.M.; Hondebrink, Erwin; Steenbergen, Wiendelt; Mul, F.F.M. de

doi:10.1109/jstqe.2003.813302

Cited by 123 publications

(90 citation statements)

References 17 publications

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“…Detection of the acoustic waves is the base of the optoacoustic (or photoacoustic) methods [1,3]. The main applications of the photoacoustic (PA) method are in the field of visualisation of strongly absorbing objects, such as blood vessels [263][264][265] and tumours [266]. This method can be also used for imaging of subcutaneous structures [267] and measuring the blood oxygenation [268].…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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Abstract.A review of specific features and methods of optical clearing and related interaction of light with tissues is presented. Physical and molecular mechanisms of immersion, compression, and photodynamic/photothermal optical clearing of some fibrous and cellular tissues are discussed. The possibility of efficient control of the tissue optical properties, particularly, the reduction of light scattering in tissues is demonstrated, which facilitates the increased efficiency of various optical visualisation methods (optical biopsy) used in medical purposes. © 2015 Samara State Aerospace University (SSAU).Keywords: tissue, optical clearing, optical diagnostics, imaging. 1, 404-413 (1997). 5. C. L. Smithpeter, A. K. Dunn, A. J. Welch, and R. Richards-Kortum, "Penetration depth limits of in vivo confocal reflectance imaging," Appl. Opt. 37, 2749Opt. 37, -2754Opt. 37, (1998. 6. V. V. Tuchin, L. V. Wang, and D. A. Zimnyakov, Optical Polarization in Biomedical Applications, SpringerVerlag, New York, NY, USA (2006). 7. R. Drezek, A. Dunn, and R. Richards-Kortum, "Light scattering from cells: finite-difference time-domain simulations and goniometric measurements," Appl. Opt. 38(16), 3651-3661 (1999). 8. K. Sokolov, R. Drezek, K. Gossagee, and R. Richards-Kortum, "Reflectance spectroscopy with polarized light:is it sensitive to cellular and nuclear morphology," Opt. Express 5, 302-317 (1999). 9. D. W. Leonard, and K. M. Meek, "Refractive indices of the collagen fibrils and extrafibrillar material of the corneal stroma," Biophysical J. 72, 1382-1387 (1997). 10. A. G. Borovoi, E. I. Naats, and U. G. Oppel, "Scattering of light by a red blood cell," J. Biomed. Opt. 3, 364-372 (1998). 11. A. N. Yaroslavsky, A. V. Priezzhev, J. Rodriguez, I. V. Yaroslavsky, and H. Battarbee, "Optics of blood,"Chap. 2 in Handbook of Optical Biomedical Diagnostics, V. V. Tuchin, Ed., pp. 169-216, PM107 SPIE Press, Bellingham, WA, USA (2002). 12. G. Mazarevica, T. Freivalds, and A. Jurka, "Properties of erythrocyte light refraction in diabetic patients," J.Biomed. Opt. 7, 244-247 (2002). 13. M. Friebel, and M. Meinke, "Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration," Appl. Opt. 45(12), 2838-2842 (2006). Appl. Opt. 35(19), 3413-3420 (1996). 34. D. Zhu, J. Wang, Z. Zhi, X. Wen, and Q. Luo, "Imaging dermal blood flow through the intact rat skin with an optical clearing method," J. Biomed. Opt. 15, 026008 (2010 241. K. König, G. Flemming, and R. Hibst, "Laser-induced autofluorescence spectroscopy of dental caries lesion," Cell. Mol. Biol. 44, 1293-1300. 242. E. G. Borisova, T. T. Uzunov, and L. A. Avramov, "Early differentiation between caries and tooth demineralization using laser-induced autofluorescence spectroscopy," Lasers Surg. Med. 34, 249-253 (2004 -20(12), 1512-1516 (1984). 245. K. Konig, H. Schneckenburger, and R. Hibst, "Time-gated in vivo autofluorescence imaging of dental caries,"Cell. Mol. Biol. 45, 233-239 (1999). 246. E. Borisova, P. Tr...

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Section: Photoacoustic Imagingmentioning

confidence: 99%

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Genina

Bashkatov

Sinichkin

et al. 2015

JBPE

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“…The incorporation of MRI and PAT into a single probe offers the unique possibility of combining the complementary strategies of contrastbased volume imaging and edge detection. Our nanoconstruct consists of zero-valence ferromagnetic cobalt (Co) particles (8) with a gold (Au) coating for biocompatibility and a unique shape rendering increased optical absorption over a broad range of frequencies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). This research theme follows the rapid developments in nanotechnology, diagnostic radiology, and targeted molecular imaging (20), whereby nanoparticulate contrast agents, with the desirable properties of high chemical specificity, biocompatibility, and a reasonable half-life, are administered within a specific region of interest.…”

mentioning

confidence: 99%

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Bouchard

Anwar

Liu

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

171

127

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Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.dual-modality imaging ͉ ferromagnetic nanoparticle ͉ molecular imaging ͉ MRI contrast ͉ photoacoustic tomography W e have synthesized nanoparticles for dual-modality (1-7)MRI and photoacoustic tomography (PAT). The incorporation of MRI and PAT into a single probe offers the unique possibility of combining the complementary strategies of contrastbased volume imaging and edge detection. Our nanoconstruct consists of zero-valence ferromagnetic cobalt (Co) particles (8) with a gold (Au) coating for biocompatibility and a unique shape rendering increased optical absorption over a broad range of frequencies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). This research theme follows the rapid developments in nanotechnology, diagnostic radiology, and targeted molecular imaging (20), whereby nanoparticulate contrast agents, with the desirable properties of high chemical specificity, biocompatibility, and a reasonable half-life, are administered within a specific region of interest. In nanoparticle-based imaging studies, higher particle concentrations lead to better signal-to-noise contrasts, but this also poses a tradeoff with the toxicity. Therefore, one of the most important parameters when developing particle-based contrast is the safest and lowest nanoparticle concentration that offers sufficient contrast sensitivity.In MRI, magnetic materials such as gadolinium chelates and magnetic nanoparticles are often used (21-23) to enhance image contrast. The magnetic nanoparticles are passivated by biocompatible coatings such as dextrin, citrate, polystyrene/divinylbenzene, and elemental gold. These coatings also detoxify the particles, resulting in enhanced lifetimes in vivo. Typical examples of magnetic nanoparticulate core-shell configurations include magnetitedextrin, magnetite-silica (24) and iron-gold (25).Laser-based PAT (9-19) is a hybrid imaging modality [see supporting information (SI) Fig. S1]. It uses a pulsed laser source to illuminate a biological sample. Light absorption by the tissue results in a transient temperature rise on the order of 10 mK. The rapid thermoelastic expansion excites ultrasonic waves that are measured by using broadband ultrasonic transducers conformally arranged around the sample. Finally, a modif...

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“…[4][5][6][7][8] Clinical application of photoacoustic imaging is hampered by its long imaging time, which leads to patient discomfort, movement artifacts, and consequently a low temporal resolution. Photoacoustic imaging systems based on a commercial ultrasound system are a logical next step toward clinical introduction.…”

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confidence: 99%

Real-time in vivo photoacoustic and ultrasound imaging

et al. 2008

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Abstract.A real-time photoacoustic imaging system is designed and built. This system is based on a commercially available ultrasound imaging system. It can achieve a frame rate of 8 frames/ sec. Vasculature in the hand of a human volunteer is imaged, and the resulting photoacoustic image is combined with the ultrasound image. The real-time photo acoustic imaging system with a hybrid ultrasound probe is demonstrated by imaging the branching of subcutaneous blood vessels in the hand. Blood vessels play a key role in homeostasis, growth, and repair of tissue. Knowledge on the presence of blood vessels, and the content of hemoglobin and its degree of oxygenation, yield crucial information regarding various applications in medicine, ranging from oncology to dermatology.A promising new technique to obtain both anatomical and functional information about the vascular bed is photoacoustic imaging. In photoacoustic imaging, a pressure transient is generated on absorption of a short pulse of light by a tissue chromophore ͑e.g., hemoglobin͒. Measurement of the pressure waves at the tissue surface enables reconstruction of the absorbed energy distribution, which yields information on the hemoglobin concentrations.Recently, photoacoustic imaging has successfully been applied to in vivo imaging of blood vessels in small animals [1][2][3] and humans. [4][5][6][7][8] Clinical application of photoacoustic imaging is hampered by its long imaging time, which leads to patient discomfort, movement artifacts, and consequently a low temporal resolution. Photoacoustic imaging systems based on a commercial ultrasound system are a logical next step toward clinical introduction. Systems reported in the literature that could be used for in vivo imaging in reflection mode ͑i.e., illumination and detection at the same side of the tissue͒ required a multichannel data-acquisition system and a computer to reconstruct the images. 5,9We present an approach in which we do not need this additional data-acquisition system and computer, as we utilize the data acquisition as well as hardware-implemented image reconstruction of a conventional ultrasound imaging system. The developed system is able to reconstruct the photoacoustic images of in vivo vasculature in real time with a frame rate of 8 frames/ sec. As this photoacoustic imaging system is based on a commercial ultrasound system, it provides hybrid photoacoustic and ultrasound imaging without the need for additional algorithms and hardware to capture the signals and reconstruct the images.An ultrasound imaging system ͑Picus, ESAOTE Europe BV, Maastricht, the Netherlands͒ was modified to synchronize the data acquisition with the firing of the laser. In addition, the emission of the ultrasound could be switched off during photoacoustic imaging. To detect the ͑laser-generated͒ ultrasound, a linear array ͑L10-5, 40 mm, 128 elements, 7.5-MHz central frequency, 75% −6-dB bandwidth͒ was connected to this ultrasound imaging system. An optical system was developed that could be connected to this linear a...

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In vivo photoacoustic imaging of blood vessels using an extreme-narrow aperture sensor

Cited by 123 publications

References 17 publications

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Optical clearing of biological tissues: prospects of application in medical diagnostics and phototherapy

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Real-time in vivo photoacoustic and ultrasound imaging

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