In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

Yashaswini, P.S.; Bettadahalli, Sadashivaiah; Ramaprasad, T. R.; Singh, Sridevi Annapurna

doi:10.1016/j.jnutbio.2016.12.010

Cited by 25 publications

(18 citation statements)

References 32 publications

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“…The cumulative effects of the combined sesamin and sesamol reduces the said inflammatory mediators, although its reducible strength is equivalent to that of the individual effects of sesamol and sesamin suggesting that the synergistic interactions are absent. For the most part, sesamin and sesamol exhibits anti-leukotriene effects, which downregulates the receptors and key enzymes of leukotriene pathway and further diminishing the pro-inflammatory leukotrienes production [110].…”

Section: Lung Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

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Section: Lung Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

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“…Among these, sesamol, sesamin sesamolin, sesaminol, ligning, and their derivatives are the prominent constituents that reported for antioxidant effects (Table ). Sesamol is one of the main constituents that has been reported to have antioxidant effect (in both in vivo and in vitro model) through reduction of lipid peroxidation, superoxide, and nitric oxide production as well as increased antioxidative enzyme (SOD, CAT, and GSH) level at a different doses ranging 10–50 mg/kg b.w (Chiang et al, ; Kang, Naito, Sakai, Uchida, & Osawa, ; Khamphio, Barusrux, & Weerapreeyakul, ; Lv, Zhu, & Liu, ; Yashaswini, Sadashivaiah, Ramaprasad, & Singh, ). Its antioxidant effect has a strong correlation with its antiinflammatory action.…”

Section: Resultsmentioning

confidence: 99%

“…Phytochemical constituents, mainly, sesamol, sesamin sesamolin, sesaminol, and their derivatives from SO, have been reported for antiinflammatory activity both in vivo and in vitro model ( Table ) . A number of constituents (sesamol, sesamolin, sesamin, sesamin derivative, and sesaminol) identified from SO showed their antiinflammatory activity by downregulating the COX‐2 activity or PGE2 synthesis (Chen et al, ; Hemshekhar et al, ; Hsieh et al, ; Hsu, Chu et al, ; Hung, Chen, & Hou, ; Jeng & Hou, ; Kong et al, ; Monteiro et al, ; Yashaswini et al, ). Other reports also demonstrated that some of these constituents (sesamol, sesamolin, sesamin, and sesaminol) inhibit the proinflammatory cytokines such as TNF‐α, IL‐1β, IL‐6, and NF‐kB either in vivo rat (Bournival, Plouffe, Renaud, Provencher, & Martinoli, ; Chen et al, ; Hemshekhar et al, ; Hsu, Chu, Chandrasekaran, & Liu, ; Jeng & Hou, ; Yashaswini et al, 2017b) or in vitro cell culture model (Bournival et al, ).…”

Section: Resultsmentioning

confidence: 99%

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Afroz

Zihad

Uddin

et al. 2019

Phytotherapy Research

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Traditionally, sesame oil (SO) has been used as a popular food and medicine. The review aims to summarize the antioxidant and antiinflammatory effects of SO and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with cyclooxygenase-2 (COX-2). For this, a literature study was made using Google Scholar, Pubmed, and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and antiinflammatory effects in various test systems, including humans, animals, and cultured cells through various pathways such as inhibition of COX, nonenzymatic defense mechanism, inhibition of proinflammatory cytokines, NF-kB or mitogenactivated protein kinase signaling, and prostaglandin synthesis pathway. Fatty acid analysis of SO using gas chromatography identified known nine fatty acids. In silico study revealed that sesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol (−9.6 to −10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid also showed binding efficiency with COX-2 to some extent (−6.0 to −8.4 kcal/mol). In summary, it is evident that SO may be one of promising traditional medicines that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.

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“…These agents have been found to exert antiinflammatory and anti-oxidative properties [26][27][28] . Specifically, sesamin has been found to halt proinflammatory cytokine production 29 .…”

Section: ■ Discussionmentioning

confidence: 99%

Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

Khorshidi¹,

Kasraianfard²,

Derakhshanfar³

et al. 2017

Acta Cir. Bras.

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Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study 1 AbstractPurpose: To evaluate the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing of postoperative surgical adhesion formation. Methods: Forty male Wistar rats were randomly assigned into five groups with eight rats in each group including control, hyaluronate, sesame, honey and silver groups. After two weeks the animals underwent laparotomy and were evaluated by two different blinded surgeons for severity of adhesions based on the two different classification scoring systems including Nair classification and cumulative adhesion scoring scale. Results:The scores of severity of adhesions in the hyaluronate and sesame groups were significantly lower than the control group based on the Nair classification (both P-values = 0.02), however based on the cumulative adhesion scoring scale just the score of severity of adhesions in the hyaluronate group was significantly lower than the control group (P-value = 0.02). In the hyaluronate group the severity of adhesions was decreased by 48% based on the cumulative adhesion scoring scale. Conclusions: Sodium hyaluronate and sesame oil may have a significant effect in preventing postoperative surgical adhesion formation.

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In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

Cited by 25 publications

References 32 publications

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study

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