In vivo evaluation of two types of bioactive scaffold used for tendon–bone interface healing in the reconstruction of anterior cruciate ligament

Zhang, Wei-Bin; Pan, Weimin; Zhang, Mingjun; Wei, Yiyong

doi:10.1007/s10529-010-0490-7

Cited by 16 publications

(10 citation statements)

References 12 publications

(13 reference statements)

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“…Nowadays, hamstring tendon autografts are the most preferred ones in clinical practice (Chechik et al 2013), with significantly less donor site morbidities than bone-patellar tendon-bone autografts (Poolman et al 2007). However, the tendon-bone healing of soft tissue tendon grafts is weak in ACL reconstruction, especially in the early stage, and a number of methods have been tried to enhance the tendon-bone healing (Hashimoto et al 2011;Zhang et al 2011;Dong et al 2012;Kuang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Zhi

Zhang

et al. 2016

Biotechnol Lett

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Section: Introductionmentioning

confidence: 99%

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Zhi

Zhang

et al. 2016

Biotechnol Lett

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“…Of the 27 included in vivo studies, two were human trials (Petruskevicius et al, 2002;Mochizuki and Ochi, 2015) and 25 were animal studies. More than half of the animal studies (n = 14) utilized a rabbit model (Zhang et al, 2011;Li et al, 2012Li et al, , 2017Jiang et al, 2014;Han et al, 2015;Chou et al, 2016;Chung et al, 2017;Lee et al, 2017;Cai et al, 2018;Hu et al, 2018;Chen P. et al, 2019;Han F. et al, 2019;Learn et al, 2019), eight studies used rats (Loeffler et al, 2013;Zhao et al, 2014Zhao et al, , 2015aKovacevic et al, 2015;Zhang et al, 2018;Zhu Q. et al, 2019), and three studies used pigs (Fleming et al, 2009;Vavken et al, 2012;Li et al, 2014). The involved patients and animals were mature, and no minor or immature animal model had been investigated in previous studies so far as searched.…”

Section: Data Extractionmentioning

confidence: 99%

A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo

Mao

Fan

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Background: Tendon-bone healing is an important factor in determining the success of ligament reconstruction. With the development of biomaterials science, the tissue engineering scaffold plays an extremely important role in tendon-bone healing and bone tissue engineering.Materials and Methods: Electronic databases (PubMed, Embase, and the Web of Science) were systematically searched for relevant and qualitative studies published from 1 January 1990 to 31 December 2019. Only original articles that met eligibility criteria and evaluated the use of issue engineering scaffold especially biomaterials in tendon bone healing in vivo were selected for analysis.Results: The search strategy identified 506 articles, and 27 studies were included for full review including two human trials and 25 animal studies. Fifteen studies only used biomaterials like PLGA, collage, PCL, PLA, and PET as scaffolds to repair the tendon-bone defect, on this basis, the rest of the 11 studies using biological interventions like cells or cell factors to enhance the healing. The adverse events hardly ever occurred, and the tendon bone healing with tissue engineering scaffold was effective and superior, which could be enhanced by biological interventions.Conclusion: Although a number of tissue engineering scaffolds have been developed and applied in tendon bone healing, the researches are mainly focused on animal models which are with limitations in clinical application. Since the efficacy and safety of tissue engineering scaffold has been proved, and can be enhanced by biological interventions, substantial clinical trials remain to be done, continued progress in overcoming current tissue engineering challenges should allow for successful clinical practice.

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“…therefore, recombined bone xenograft (RBX), a new type of biosynthetic material which can be directly incorporated into injectable CPC, has been suggested to be more effective in augmenting bone ingrowth in animal models (20). RBX has already been used as a BMP carrier, showing accelerated tendon-bone healing (21). Moreover, Weimin et al (22) showed that RBX further accelerated tendon-to-bone healing and provided higher maximum loads to failure when compared with injectable CPC alone after ACL reconstruction in a rabbit model.…”

Section: Bone Proteins and Growth Factorsmentioning

confidence: 99%

Biological enhancement of graft-tunnel healing in anterior cruciate ligament reconstruction

Saccomanno¹,

Capasso²,

Fresta³

et al. 2016

Joints

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Abstractthe sites where graft healing occurs within the bone tunnel and where the intra-articular ligamentization process takes place are the two most important sites of biological incorporation after anterior cruciate ligament (ACL) reconstruction, since they help to determine the mechanical behavior of the femur-ACL graft-tibia complex. Graft-tunnel healing is a complex process influenced by several factors, such as type of graft, preservation of remnants, bone quality, tunnel length and placement, fixation techniques and mechanical stress. in recent years, numerous experimental and clinical studies have been carried out to evaluate potential strategies designed to enhance and optimize the biological environment of the graft-tunnel interface. Modulation of inflammation, tissue engineering and gene transfer techniques have been applied in order to obtain a direct-type fibrocartilaginous insertion of the ACL graft, similar to that of native ligament, and to accelerate the healing process of tendon grafts within the bone tunnel. Although animal studies have given encouraging results, clinical studies are lacking and their results do not really support the use of the various strategies in clinical practice. Further investigations are therefore needed to optimize delivery techniques, therapeutic concentrations, maintenance of therapeutic effects over time, and to reduce the risk of undesirable effects in clinical practice.

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In vivo evaluation of two types of bioactive scaffold used for tendon–bone interface healing in the reconstruction of anterior cruciate ligament

Cited by 16 publications

References 12 publications

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model

A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo

Biological enhancement of graft-tunnel healing in anterior cruciate ligament reconstruction

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