In vivo degradation of poly (ε-caprolactone) films in Gastro Intestinal (GI) tract

Chang, Hao‐Ming; Huang, Chun-Chiang; Parasuraman, Vijaya Rohini; Jhu, Jheng-Jun; Tsai, Chi-Yang; Chao, Hsiao-Ying; Lee, Ya-Lun; Tsai, Hsieh‐Chih

doi:10.1016/j.mtcomm.2017.01.006

Cited by 15 publications

(6 citation statements)

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“…Our trachea tissue engineering community may benefit from lessons learned in working in open environments, including gastrointestinal, 25,26 oral, 27 esophageal, 28 and skin regeneration. 29 In addressing the aforementioned concerns, numerous potential options exist.…”

Section: Discussionmentioning

confidence: 99%

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

Townsend

Ott

Salash

et al. 2018

Tissue Engineering Part A

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Tracheal stenosis caused by congenital anomalies, tumors, trauma, or intubation-related damage can cause severe breathing issues, diminishing the quality of life, and potentially becoming fatal. Current treatment methods include laryngotracheal reconstruction or slide tracheoplasty. Laryngotracheal reconstruction utilizes rib cartilage harvested from the patient, requiring a second surgical site. Slide tracheoplasty involves a complex surgical procedure to splay open the trachea and reconnect both segments to widen the lumen. A clear need exists for new and innovative approaches that can be easily adopted by surgeons, and to avoid harvesting autologous tissue from the patient. This study evaluated the use of an electrospun patch, consisting of randomly layered polycaprolactone (PCL) nanofibers enveloping 3D-printed PCL rings, to create a mechanically robust, suturable, air-tight, and bioresorbable graft for the treatment of tracheal defects. The study design incorporated two distinct uses of PCL: electrospun fibers to promote tissue integration, while remaining air-tight when wet, and 3D-printed rings to hold the airway open and provide external support and protection during the healing process. Electrospun, reinforced tracheal patches were evaluated in an ovine model, in which all sheep survived for 10 weeks, although an overgrowth of fibrous tissue surrounding the patch was observed to significantly narrow the airway. Minimal tissue integration of the surrounding tissue and the electrospun fibers suggested the need for further improvement. Potential areas for further improvement include a faster degradation rate, agents to increase cellular adhesion, and/or an antibacterial coating to reduce the initial bacterial load.

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Section: Discussionmentioning

confidence: 99%

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

Townsend

Ott

Salash

et al. 2018

Tissue Engineering Part A

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“…As anticipated, mineral deposits were accumulated on the surface of PCL biocomposites 11 . Based on the previous reports, hydrolytic degradation is the main process of PCL decomposition in which the carboxyl and hydroxyl groups are formed by hydrolysis of ester bonds on the PCL surface 21,26 . Then, these generated functional groups can interact with the positively charged ions in order to initiate the nucleation of hydroxyapatite crystals.…”

Section: Discussionmentioning

confidence: 70%

Three‐dimensional porous poly(ε‐caprolactone)/beta‐tricalcium phosphate microsphere‐aggregated scaffold for bone tissue engineering

ShiraliPour

Shafiei

Nikakhtar

2021

Int J Applied Ceramic Tech

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In this study, porous scaffolds made of polycaprolactone (PCL)/β‐tricalcium phosphate (BTCP) biocomposite were fabricated for bone tissue engineering (BTE) applications. The microsphere‐aggregated scaffolds were prepared with various BTCP concentrations (10wt%, 20wt%, 50wt%) by the freeze‐drying method. The porosity of obtained microsphere‐aggregated scaffolds with various pore sizes was 80–85%, where this value was about 70% for the PCL/BTCP (50) sample with no microsphere formation. The results indicated that adding BTCP has enhanced mechanical strength, and the mineralization of PCL/BTCP composite scaffolds has been increased compared to the pure PCL scaffolds in simulated body fluid (SBF). The adhesion and proliferation of mouse bone marrow mesenchymal stem cells (mMSCs) seeded onto PCL/BTCP scaffolds were enhanced compared to the PCL. In addition, in terms of differentiation, the incorporation of BTCP led to increasing the mineral deposition and alkaline phosphatase activity of mMSCs. The synergistic effect of using microsphere‐aggregated scaffolds along with BTCP as a reinforcing agent in PCL biocomposite showed that these porous biocomposite scaffolds have the potential application in BTE.

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“…[ 82 ]. In vivo degradation rate of polyester is higher than the in vitro degradation rate more presumably due to optimum concentration of ester cleaving enzymes, such as lipase in human body [ 83 ].…”

Section: Native Bone Structure and Compositionmentioning

confidence: 99%

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

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In vivo degradation of poly (ε-caprolactone) films in Gastro Intestinal (GI) tract

Cited by 15 publications

References 50 publications

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

Three‐dimensional porous poly(ε‐caprolactone)/beta‐tricalcium phosphate microsphere‐aggregated scaffold for bone tissue engineering

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

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In vivo degradation of poly (ε-caprolactone) films in Gastro Intestinal (GI) tract

Cited by 15 publications

References 50 publications

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

Three​‐dimensional porous poly(ε‐caprolactone)/beta‐tricalcium phosphate microsphere‐aggregated scaffold for bone tissue engineering

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

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Resources

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Three‐dimensional porous poly(ε‐caprolactone)/beta‐tricalcium phosphate microsphere‐aggregated scaffold for bone tissue engineering