“…As reported in previous studies, mineral sediments on pure PCL scaffolding are due to hydrolytic degradation of PCL, which is mainly caused by severing ester bonds on the surface of PCL fibers, which leads to the formation of a negative charge, carboxyl groups (-COOH) and hydroxyl (-OH). The basis of mineral sediments and their growth is the adsorption of calcium cations by negatively charged groups on the surface of scaffolds, which leads to the creation of hydroxyapatite crystals in the form of PO 4 ( Pitt et al, 1981 ; Kokubo, 1991 ; Persenaire et al, 2001 ; Bravo-Suárez et al, 2004 ; Leong, 2004 ; Oyane et al, 2005 ; Sugawara et al, 2005 ; Kokubo and Takadama, 2006 ; LeGeros, 2008 ; Guarino and Ambrosio, 2010 ; Yang et al, 2010 ; Cipitria et al, 2011 ; Fayyazbakhsh et al, 2012 ; Jaiswal et al, 2012 ; Krishna and Pugazhenthi, 2013 ; Gaharwar et al, 2014 ; Lakatos et al, 2014 ; Li et al, 2014 ; Wu et al, 2015 ; Halling Linder et al, 2016 ; Shafiei et al, 2016 ; Conoscenti et al, 2017 ; Kino et al, 2017 ; Mohammadi et al, 2017 ; Diaz-Rodriguez et al, 2018 ; Gandolfi et al, 2019 ; Hosseini et al, 2019 ; Iviglia et al, 2019 ; Morejón et al, 2019 ; Mozaffari et al, 2019 ; Tohidlou et al, 2019 ; Bagheri and Mahmoodzadeh, 2020 ; Baradaran et al, 2020 ; Makwana et al, 2020 ; ShiraliPour et al, 2021 ). Additionally, Many previous investigations have shown that LDH plays a significant role in osteogenesis and mineralization ( Baradaran et al, 2020 ; Cheng et al, 2021 ).…”