In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction

Ocular Surface Reconstitution

“…Scleral buckle composed of biodegradable collagen-glycosaminoglycan copolymer had been reported to be safe and effective in a rabbit model (Wu et al, 2008). Similar results have been demonstrated with modified porous poly(lactide-co-glycolide) scaffold as well (Lee et al, 2003). These findings provide insight into cellular behaviors and assist in the understanding of conjunctival tissue bioengineering.…”

Synaptic transmission of neural stem cells seeded in 3-dimensional PLGA scaffolds

“…PLGA scaffold is biodegradable and may prevent scarring and cyst formation in the SCI animal models [3,15]. While disassociated single-cells may have compromised viability [16], neurospheres of NSCs seeded into scaffolds of the polymers showed improved survival and differentiation [16,17].…”

Neurotrophin-3 Gene-Modified Schwann Cells Promote TrkC Gene-Modified Mesenchymal Stem Cells to Differentiate into Neuron-Like Cells in Poly(Lactic-Acid-Co-Glycolic Acid) Multiple-Channel Conduit

“…Recently, nerve tissue engineering has attracted increasing attention for repairing SCI, in which synthetic biomaterials serve as a structural frame to bridge the injured gap and to provide guidance for newly regenerated axons [Moore et al, 2006;Guo et al, 2007]. Synthetic polymers, such as poly(lacticacid-co-glycolic acid) (PLGA), have advantages with regard to ease of fabrication, mechanical strength and biodegradability, and thus have been used to reconstruct spinal cord tissue architecture, to prevent the infiltration of scar tissue and to decrease inflammatory response [Teng et al, 2002;Lee et al, 2003]. Meanwhile, the porous polymer simultaneously serves as a cell delivery vehicle, which avoids injecting the cells into the host within large cavities [Olson et al, 2009].…”