Synaptic transmission of neural stem cells seeded in 3-dimensional PLGA scaffolds

Yu, Xiong; Zeng, Yuan-Shan; Zeng, Chenguang; Du, Bao-Ling; He, Liumin; Quan, Daping; Zhang, Wei; Wang, Junmei; Wu, Jin-Lang; Li, Yan; Li, Jun

doi:10.1016/j.biomaterials.2009.03.046

Cited by 95 publications

(62 citation statements)

References 34 publications

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“…Among the diverse forms of PLGA-based drug delivery systems microspheres or microparticles are the most common (Fredenberg et al, 2011). Other types consist of nanoparticles (Sharma et al, 2007), films (Klose et al, 2008), cylinders (Desai et al, 2010), in situ forming implants or microparticles (Dong et al, 2006), scaffolds (Xiong et al, 2009) and foams (Fredenberg et al, 2011;Ong et al, 2009). Protocols have been optimized for PLGA nanoparticles synthesis and many cancer related drugs have been incorporated in PLGA (Hans and Lowman, 2002;Kumari et al, 2010).…”

Section: Plga Nanoparticles For Drug Delivery To Tumorsmentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

392

154

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Section: Plga Nanoparticles For Drug Delivery To Tumorsmentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

392

154

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“…Among the different forms of PLGA-based DDSs, microspheres or microparticles are the most common. Other types include nanoparticles (68) , films (45) , cylinders (22) , in situ forming implants or microparticles (23) , scaffolds (82) , and foams (57) . PLGA implants may be surgically inserted at the desired location, giving the advantage of local drug delivery of, for example, antibiotics or anti-cancer drugs (80,83) .…”

Section: Plga Based Drug Delivery Devicesmentioning

confidence: 99%

Poly(Lactic-Co-Glycolic Acid) Based Drug Delivery Devices For Tissue Engineering And Regenerative Medicine

Kerımoğlu¹,

Alarçin²

2012

Ankem Derg

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“…However, it is critical to predifferentiate NSCs into OPCs before applying CNTF so as to avoid astrocytic differentiation of NSCs as triggered by CNTF effect 22. Our previous studies focused on using NT‐3 and its receptor TrkC gene modification technique to promote neuronal differentiation of NSCs with synaptic transmission capability 11, 23. Here, we have adopted the same technique to construct the GMLT.…”

Section: Discussionmentioning

confidence: 99%

A Modular Assembly of Spinal Cord–Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord

et al. 2018

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Tissue engineering–based neural construction holds promise in providing organoids with defined differentiation and therapeutic potentials. Here, a bioengineered transplantable spinal cord–like tissue (SCLT) is assembled in vitro by simulating the white matter and gray matter composition of the spinal cord using neural stem cell–based tissue engineering technique. Whether the organoid would execute targeted repair in injured spinal cord is evaluated. The integrated SCLT, assembled by white matter–like tissue (WMLT) module and gray matter–like tissue (GMLT) module, shares architectural, phenotypic, and functional similarities to the adult rat spinal cord. Organotypic coculturing with the dorsal root ganglion or muscle cells shows that the SCLT embraces spinal cord organogenesis potentials to establish connections with the targets, respectively. Transplantation of the SCLT into the transected spinal cord results in a significant motor function recovery of the paralyzed hind limbs in rats. Additionally, targeted spinal cord tissue repair is achieved by the modular design of SCLT, as evidenced by an increased remyelination in the WMLT area and an enlarged innervation in the GMLT area. More importantly, the pro‐regeneration milieu facilitates the formation of a neuronal relay by the donor neurons, allowing the conduction of descending and ascending neural inputs.

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Synaptic transmission of neural stem cells seeded in 3-dimensional PLGA scaffolds

Cited by 95 publications

References 34 publications

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Poly(Lactic-Co-Glycolic Acid) Based Drug Delivery Devices For Tissue Engineering And Regenerative Medicine

A Modular Assembly of Spinal Cord–Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord

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