In Vivo Characteristics of Injectable Poly(DL-Lactic Acid) Microspheres for Long-Acting Drug Delivery

Abstract

Poly(DL-lactic acid) (PLA) microspheres containing testosterone (T) were prepared by the solvent evaporation process to evaluate their physical properties such as size distribution, shape, drug content, in vivo controlled drug release, pharmacological influences on the prostate gland in castrated rats, and histopathological findings of tissues surrounding the implants. The in vivo release of T from PLA microspheres containing 30 mg of drug obtained with chloroform was continued over a 6-week period. This effect is attributed to high dispersibility of T in the device when obtained with chloroform. Both serum drug levels and prostate gland weight recovery suggested the effects of a long-acting drug delivery system. The histopathological findings showed that the devices used were completely degraded 10 weeks after injection.

Tissue response to partially in vitro predegraded poly-L-lactide implants

“…However, studies were also reported where long-term complete degradation did not result in local complications [16,17,19]. For poly-DL-lactic acid in the formulation of microspheres for drug delivery complete degradation was already observed after 8 weeks [20]. So, various reactions can occur depending on the actual composition and production method of the poly-L-lactide (co)polymer.…”

Strengthening and toughening of poly(L-lactide) composites by surface modified MgO whiskers

“…Aliphatic polyesters have attracted wide attention due to their biodegradability, biocompatibility and processibility [2][3][4] and widely used in biomedical fields, such as absorbable bone screws, tissue engineering, surgical sutures and drug controlled release [5,6]. However, there are some problems for the use of these polymers in biomedical materials field, especially for cortical bone repair materials.…”

Designing biodegradable multiblock PCL/PLA thermoplastic elastomers

“…Biodegradable polymers are used in traditional applications, such as surgical sutures [1,2] and matrices for drug delivery [3][4][5], and recently they became also the basis of more advanced biomedical systems. The field of Tissue Engineering, for example, capitalized on their degradability to create the temporary scaffolds required for cell growth and tissue regeneration [6][7][8].…”