Tissue response to partially in vitro predegraded poly-L-lactide implants

Jong, Wim H. de; Bergsma, J. E.; Robinson, Joke; Bos, Rein

doi:10.1016/j.biomaterials.2004.06.026

Cited by 89 publications

(65 citation statements)

References 40 publications

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“…In all cases the ED2-positive cells (mature macrophages) were found sparsely distributed and encapsulating the ED1-positive cells. This pattern is commonly found in cases of chronic inflammation caused by subcutaneous implantation of polymeric biomaterials (De Jong et al 2005;Hagerty et al 2000;Marques et al 2005;Rosengren et al 1997). Marques and colleagues (Marques et al 2005) studied the host response to a variety of starchbased polymers implanted in rats and observed that ED1-positive macrophages immediately migrated to, and layered the implant surface with a thickness dependent on the material type.…”

Section: Discussionmentioning

confidence: 96%

The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells

Luong-Van

Grøndahl

Song³

et al. 2007

J Mol Hist

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Human mesenchymal stem cells (hMSCs) are an attractive tissue engineering avenue for the repair and regeneration of bone. In this study we detail the in vivo performance of a novel electrospun polycaprolactone scaffold incorporating the glycosaminoglycan heparan sulfate (HS) as a carrier for hMSC. HS is a multifunctional regulator of many key growth factors expressed endogenously during bone wound repair, and we have found it to be a potent stimulator of proliferation in hMSCs. To assess the potential of the scaffolds to support hMSC function in vivo, hMSCs pre-committed to the osteogenic lineage (human osteoprogenitor cells) were seeded onto the scaffolds and implanted subcutaneously into the dorsum of nude rats. After 6 weeks the scaffolds were retrieved and examined by histological methods. Implanted human cells were identified using a human nuclei-specific antibody. The host response to the implants was characterized by ED1 and ED2 antibody staining for monocytes/macrophages and mature tissue macrophages, respectively. It was found that the survival of the implanted human cells was affected by the host response to the implant regardless of the presence of HS, highlighting the importance of controlling the host response to tissue engineering devices.

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Section: Discussionmentioning

confidence: 96%

The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells

Luong-Van

Grøndahl

Song³

et al. 2007

J Mol Hist

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show abstract

“…Nevertheless, there are still some challenges to be solved. One of the complications was related to airway stenosis, which may be caused by the degradation byproduct from implanted biodegradable scaffold materials (De Jong, Bergsma, Robinson & Bos, 2005;Krajc, Janik, Lucenic, Benej & Harustiak, 2010). The scaffold materials thus play an important role in tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

A tracheal scaffold of gelatin-chondroitin sulfate-hyaluronan-polyvinyl alcohol with orientated porous structure

Qian

Chen

et al. 2017

Carbohydrate Polymers

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“…Its importance is underscored by the fact that in humans PLA bone implants showed a late adverse tissue response against phagocytized poly(L-)lactide crystalline particles after more than 5 years [46]. Similar results were obtained in a more recent study using predegraded PLA96 after subcutaneous implantation in rats, which proved a suitable alternative to study late degradation reactions [47]. That biofunctionality aspects, such as tissue volume generated and tissue consistency, can be studied by this approach, seems unlikely.…”

Section: Discussionmentioning

confidence: 68%

Long-term Evaluation of Porous PEGT/PBT Implants for Soft Tissue Augmentation

Lamme

Druecke

Pieper³

et al. 2008

J Biomater Appl

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Porous PEGT/PBT implants with different physico-chemical characteristics were evaluated to identify its potential as biodegradable and biofunctional soft tissue filler. Implants (50 Â 10 Â 5mm3 ) were implanted subcutaneously in mini-pigs and tissue response, tissue volume generated and its consistency were assessed quantitatively with a 52 weeks follow-up. The absence of wound edema, skin irritation, and chronic inflammation demonstrated biocompatibility of all implants evaluated. The hydrophobic implants induced the mildest foreign body response, generated highest amount of connective tissue and demonstrated a decrease in copolymer MW of 34-37% compared to 90% decrease of the hydrophilic implants. The rate and extent of copolymer fragmentation seems to be the determining factor of success of soft tissue augmentation using porous PEGT/PBT copolymer implants.

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Tissue response to partially in vitro predegraded poly-L-lactide implants

Cited by 89 publications

References 40 publications

The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells

The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells

A tracheal scaffold of gelatin-chondroitin sulfate-hyaluronan-polyvinyl alcohol with orientated porous structure

Long-term Evaluation of Porous PEGT/PBT Implants for Soft Tissue Augmentation

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