In vivo Cariostatic Effect of Black Copper Cement on Carious Dentine

Abstract

This study compared the effect of a copper phosphate cement (BCC) and a conventional glass ionomer cement (GIC) on carious dentine that remains under restorations in vivo. Using a split-mouth design, 45 primary molar pairs with dentine caries were sampled microbiologically. Without further removal of carious dentine, the molar pairs were randomly allocated to three restorative groups: (1) one cavity was lined with BCC and restored with GIC and the other was kept under review as an untreated control; (2) one cavity was restored with GIC, whilst the other was kept under review; (3) one cavity was lined with BCC and restored with GIC, whilst the other was filled with GIC. The dentine was re-sampled microbiologically at 1 month (30 pairs) and 6 months (15 pairs). BCC demonstrated a significant effect on the total anaerobic count over 1 month, when paired with both the control and GIC, whereas the antibacterial effects of GIC compared with no treatment were not statistically significant. In addition, BCC performed significantly better than no treatment in reducing mutans streptococci and lactobacilli over 1 month. Over 6 months, BCC caused a significantly greater reduction in mutans streptococci than GIC. In conclusion, BCC demonstrated a significant antibacterial effect on carious dentine in vivo.

Restorative materials containing antimicrobial agents: is there evidence for their antimicrobial and anticaries effects? A systematic review

“…Irrespective of the antimicrobial incorporated into restorative material/dental adhesives, a reduction in bacterial viability has been found; this is in agreement with data from a recent literature review which found restorative filling material containing antimicrobial properties does exert an antimicrobial effect on bacteria commonly found in the oral cavity . Specifically, the effects of MDPB and CHX have been extensively tested in in vitro and in short‐term clinical studies . The antimicrobial effects of NAg have only been tested under in vitro conditions.…”

Copper as a Biocidal Tool

“…Similarly, it was found that the antibacterial potency of several compounds is significantly higher when they are complexed with copper [10,11]. Likewise, copper phosphate cement used as a restorative material for treatment of caries demonstrated the greatest in vitro and in vivo antibacterial activity, among several restorative materials tested [12,13]. Addition of activated copper significantly improved the antibacterial properties of calcium hydroxide used to kill bacteria in dentinal tubules [14].…”

Synthesis and antibacterial property of zinc loaded hydroxyapatite nanorods

“…The antibacterial activities of the as-prepared Zn-loaded calcium phosphate nanostructures were evaluated against the most common oral pathogenic bacteria: Aggregatibacter actinomycetemcomitans (FDCY4, Aa), Fusobacterium nucleatum (ATCC25586, Fn) and Streptococcus mutans (UA159, Sm) using the liquid diffusion method [13]. The concentration of bacteria was adjusted to 3 Â 10 8 CFU/mL.…”