Synthesis and antibacterial property of zinc loaded hydroxyapatite nanorods

Chen, Xi; Tang, Qi-Li; Zhu, Yunlong; Zhu, Cancan; Feng, Xiping

doi:10.1016/j.matlet.2012.08.115

Cited by 55 publications

(26 citation statements)

References 17 publications

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“…Studies confirmed the efficiency of hydroxyapatites doped with zinc ions in reducing the growth of the three most common oral pathogens, including Aggregatibacter actinomycetemcomitans , Fusobacterium nucleatum , and S. mutans [94] (see Table 1). …”

Section: Zn2+-substituted Hydroxyapatitementioning

confidence: 90%

Substituted Hydroxyapatites with Antibacterial Properties

Kolmas

Groszyk

Kwiatkowska-Różycka

2014

BioMed Research International

214

131

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Reconstructive surgery is presently struggling with the problem of infections located within implantation biomaterials. Of course, the best antibacterial protection is antibiotic therapy. However, oral antibiotic therapy is sometimes ineffective, while administering an antibiotic at the location of infection is often associated with an unfavourable ratio of dosage efficiency and toxic effect. Thus, the present study aims to find a new factor which may improve antibacterial activity while also presenting low toxicity to the human cells. Such factors are usually implemented along with the implant itself and may be an integral part of it. Many recent studies have focused on inorganic factors, such as metal nanoparticles, salts, and metal oxides. The advantages of inorganic factors include the ease with which they can be combined with ceramic and polymeric biomaterials. The following review focuses on hydroxyapatites substituted with ions with antibacterial properties. It considers materials that have already been applied in regenerative medicine (e.g., hydroxyapatites with silver ions) and those that are only at the preliminary stage of research and which could potentially be used in implantology or dentistry. We present methods for the synthesis of modified apatites and the antibacterial mechanisms of various ions as well as their antibacterial efficiency.

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Section: Zn2+-substituted Hydroxyapatitementioning

confidence: 90%

Substituted Hydroxyapatites with Antibacterial Properties

Kolmas

Groszyk

Kwiatkowska-Różycka

2014

BioMed Research International

214

131

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“…Additionally, antibacterial and antifungal effects of Zn doped HA against Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were also documented in solid and liquid media [13]. Moreover, Zn-HA nano-rods presented improved performance to decrease oral cavity bacteria [14].…”

Section: Introductionmentioning

confidence: 92%

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Uysal

Severcan

Tezcaner

et al. 2014

Progress in Natural Science: Materials International

105

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Hydroxyapatite (HA) co-doped with Zn 2 þ and F À ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn 2 þ and F À ions incorporation into HA structure. Co-doping of Zn 2 þ and F À ions decreased unit cell volume of HA and decreased grain sizes. Zn 2 þ or 5 mol% F À addition into HA significantly improved its density. Microhardness was increased with Zn 2 þ addition and further increase was detected with F À co-doping. Zn 2 þ and F À co-doped samples had higher fracture toughness than pure HA. Zn 2 þ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F À addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications.

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“…Considering these outstanding properties, Zn-HAps were used as coatings of dental implants in order to promote tooth remineralization, allowing to reduce bacterial adherence and the tartar development, having verified their efficiency to inhibit the growth of the three most common oral pathogens, i.e., Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and S. mutans [159].…”

Section: Influence Of Znmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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Synthesis and antibacterial property of zinc loaded hydroxyapatite nanorods

Cited by 55 publications

References 17 publications

Substituted Hydroxyapatites with Antibacterial Properties

Substituted Hydroxyapatites with Antibacterial Properties

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Cationic and Anionic Substitutions in Hydroxyapatite

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