Copper as a Biocidal Tool

Borkow, Gadi; Gabbay, Jeffrey

doi:10.2174/0929867054637617

Cited by 608 publications

(388 citation statements)

References 131 publications

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“…Also consistent with five independent CUP1 amplification events, there was very little CUP1 sequence heterogeneity and no CUP1-linked SNPs associated with CUP1 copy number or with copper resistance. We hypothesize that independent CUP1 gene amplification events, and increased copper resistance, have been selected by the agricultural use of fungicidal copper salts (Borkow and Gabbay 2005;Holb 2009;Mackie et al 2012) in natural S. cerevisiae environments. Similar to Warringer et al (2011), we observed CUP1 copy number association with copper resistance and that CUP1 copy number was responsible for ∼50% of copper resistance.…”

Section: Chromosomal Rearrangements Aneuploidy and Introgressionmentioning

confidence: 99%

The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen

et al. 2015

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Saccharomyces cerevisiae, a well-established model for species as diverse as humans and pathogenic fungi, is more recently a model for population and quantitative genetics. S. cerevisiae is found in multiple environments-one of which is the human body-as an opportunistic pathogen. To aid in the understanding of the S. cerevisiae population and quantitative genetics, as well as its emergence as an opportunistic pathogen, we sequenced, de novo assembled, and extensively manually edited and annotated the genomes of 93 S. cerevisiae strains from multiple geographic and environmental origins, including many clinical origin strains. These 93 S. cerevisiae strains, the genomes of which are near-reference quality, together with seven previously sequenced strains, constitute a novel genetic resource, the "100-genomes" strains. Our sequencing coverage, highquality assemblies, and annotation provide unprecedented opportunities for detailed interrogation of complex genomic loci, examples of which we demonstrate. We found most phenotypic variation to be quantitative and identified population, genotype, and phenotype associations. Importantly, we identified clinical origin associations. For example, we found that an introgressed PDR5 was present exclusively in clinical origin mosaic group strains; that the mosaic group was significantly enriched for clinical origin strains; and that clinical origin strains were much more copper resistant, suggesting that copper resistance contributes to fitness in the human host. The 100-genomes strains are a novel, multipurpose resource to advance the study of S. cerevisiae population genetics, quantitative genetics, and the emergence of an opportunistic pathogen.

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Section: Chromosomal Rearrangements Aneuploidy and Introgressionmentioning

confidence: 99%

The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen

et al. 2015

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“…It is also a well-known bactericide, although the mechanisms involved in copper-mediated injury have not yet been resolved (Borkow & Gabbay, 2005;Macomber et al, 2007). In order to prevent copper damage, the cytoplasmic concentration of free copper must be negligible.…”

Section: Introductionmentioning

confidence: 99%

Dissecting the Salmonella response to copper

et al. 2007

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“…In this study, we analyzed the capacity of reducing root intrusion into the emitters by incorporating microscopic copper particles during the manufacture of the emitters, as copper is known as a potent algaecide (Borkow and Gabbay 2005;Murray-Gulde et al 2002).…”

Section: Discussionmentioning

confidence: 99%