In vivo bioprinting: Broadening the therapeutic horizon for tissue injuries

In Situ Bioprinting: Process, Bioinks, and Applications

“…22−24 The ability to recreate complex tissue structures in vivo facilitates a more accurate representation of the native microenvironment, providing researchers with valuable tools for studying tissue development, disease progression, and therapeutic interventions. 21 This not only enhances our understanding of biological processes but also accelerates the translation of research findings from laboratory to clinical applications. Moreover, in situ bioprinting aligns with the principles of precision medicine by offering a patient-specific tissue engineering approach.…”

“…20 This technique is a departure from the traditional bioprinting methods, which often involve the creation of tissue constructs ex vivo before transplantation. 21 The potential of in situ bioprinting lies in its ability to create intricate tissue structures in real time, and tailored to the specific needs of the patient. This method enhances accuracy, adhesion, and tissue integration, offering a more targeted and efficient solution.…”

“…It involves the direct deposition of biomaterials, cells, and other bioactive factors at the site of interest, allowing on-site fabrication of complex tissues . This technique is a departure from the traditional bioprinting methods, which often involve the creation of tissue constructs ex vivo before transplantation . The potential of in situ bioprinting lies in its ability to create intricate tissue structures in real time, and tailored to the specific needs of the patient.…”

“…The potential of in situ bioprinting lies in its ability to create intricate tissue structures in real time, and tailored to the specific needs of the patient. This method enhances accuracy, adhesion, and tissue integration, offering a more targeted and efficient solution. − The ability to recreate complex tissue structures in vivo facilitates a more accurate representation of the native microenvironment, providing researchers with valuable tools for studying tissue development, disease progression, and therapeutic interventions . This not only enhances our understanding of biological processes but also accelerates the translation of research findings from laboratory to clinical applications.…”

Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

“…Diverse materials have been designed to realize remote manipulability [ [22] , [23] , [24] , [25] ] of cell-material interplay via magnetic field [ [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] ] or ultraviolet (UV)-free light [ 20 , [39] , [40] , [41] , [42] , [43] , [44] , [45] ] to acquire superior tissue penetrability for in vivo applications. Photoisomers can undergo photoisomerization in response to dual- or single-wavelength light in the range of UV and visible (Vis) light wavelengths [ 46 ], thus enabling the cell regulation [ 47 ].…”