In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals

Singh, Kamlesh; Singh, Nisha; Chandy, Anish; Manigauha, Ashish

doi:10.1016/s2221-1691(12)60061-6

Cited by 60 publications

(37 citation statements)

References 19 publications

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“…A significant decrease in SGPT, SGOT and ALP levels was observed in all drug treated groups as compared to thioacetamide group (P< 0.001), furthermore, significant (P< 0.001) increase in SOD, CAT, GRD, GPX and GST was observed in all drug treated groups as compared with thioacetamide group. However, a significant (P< 0.001) reduction in LPO was observed as compared to toxic control group [129].The effect of carrot extract on CCl 4 -induced acute liver damage was evaluatedin mice. The extracts significantly lowered the serum levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, sorbitol and glutamate dehydrogenase elevated by CCl4-induction.…”

Section: Nephroprotective and Hepatoprotective Effectsmentioning

confidence: 97%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Phytochemical analysis showed that the root of Daucus carota contained alkaloids, carbohydrates, chlorogenic acid, flavonoids, phenols, essential oil, terpenoid and coumarin. The nutritional analysis of carrot juice showed that the juice contained: protein 1.067 ± 0.058%, crude fat 0.367 ± 0.089%, crude fibre 1.167 ± 0.153%, carbohydrates 6.100 ± 0.346%, many vitamins and minerals. The pharmacological studies revealed that the plant possessed cytotoxic, antioxidant, antidiabetic, antimicrobial, smooth muscle relaxant, hypotensive effect and decrease intraocular pressure, gastro-protective, nephro-protective, hepato-protective, cardioprotective antidepressant memory enhancement, anti-inflammatory, reproductive, wound healing and hear induction and many other effects. The current review highlights the chemical constituents, nutritional and pharmacological effects of Daucus carota.

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Section: Nephroprotective and Hepatoprotective Effectsmentioning

confidence: 97%

Nutritional and therapeutic importance of Daucus carota- A review

Al-Snafi¹

2017

IOSRPHR

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“…This effect would be manifested by stabilization of the hepatic membrane and regeneration of the hepatocytes. The extract also prevents the release of hepatic enzymes to the blood stream by reducing tissue lesions (Madhu et al, 2012;Singh et al, 2012). The hepatoprotective activity of A. cordifolia has already been demonstrated in rats against hepatotoxicity induced by high doses of paracetamol (Arhoghro et al, 2015;Olaleye et al, 2006Olaleye et al, , 2007 and tetrachloride (Osadebe et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of methanol extract of Alchornea cordifolia leaves against anti-tubercular drugs induced hepatotoxicity in rats

Etienne¹,

Landry²,

Genevieve³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Alchornea cordifolia has been shown to be hepatoprotective against hepatotoxicity induced by high dose paracetamol in a model animal. However, its hepatoprotective effects against the hepatotoxicity induced by anti-tubercular drugs have not yet been studied, whereas anti-tubercular drugs are known to be hepatotoxic at therapeutic dose. The aim of this work was to evaluate the hepatoprotective effect of a methanol extract of A. cordifolia leaves in order to overcome hepatotoxicity induced by antitubercular drugs. Isoniazid, Rifampicin and Pyrazinamid have been used to induce hepatotoxicity in rats. The animals were administered hepatotoxic agent. Two hours later they were given methanol extract of A. cordifolia (MEAC) leaves or silymarin. One group of animals received only the antitubercular drugs, one group received MEAC only and another group received physiological saline. The animals were thus treated for 10 consecutive days. Blood sample was taken on the 11th day for evaluation of the biochemical parameters, as well as markers of hepatotoxicity. Isoniazid increased transaminases (ALT and AST), MEAC and silymarin reduced these biochemical parameters, Isoniazid + Rifampicin increased ALT and AST levels, MEAC reduced alanine transaminase (ALT) and aspartate transaminase (AST) levels, Isoniazid + Rifampicin + Pyrazinamid combination resulted in significant ALT elevation and MEAC reduced the ALT levels. MEAC alone did not significantly alter ALT and AST values. Phytochemical screening revealed the presence of flavonoids, polyphenols, saponosides and alkaloids. A. cordifolia leaves would thus have a protective effect against anti-tubercular drugs induced hepatotoxicity in rats.

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“…This activity would be manifested by stabilization of the hepatic membrane and regeneration of the hepatocytes. The extract would also prevent the release of hepatic enzymes at the level of the blood stream by a reduction of the tissue lesions [40] [41].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Hepatoprotective Effect of an Aqueous Extract of <i>Alchornea cordifolia</i> Leaves

Effo¹,

Kouakou²,

Irie-N’Guessan³

et al. 2017

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Alchornea cordifolia is a medicinal plant, whose ethanolic and methanolic extracts have shown antioxidant activity which could confer hepatoprotective effect, knowing that liver cells are attacked by free radicals. The hepatoprotective effect of these extracts has been demonstrated in models of hepatotoxicity induced by paracetamol high doses in animals. However, anti-tubercular drugs at the usual dose present hepatotoxicity risk. Could Alchornea cordifolia help to limit hepatotoxicity induced by anti-tubercular drugs? This work aimed to evaluate the antioxidant activity and the hepatoprotective effect of an aqueous extract of A. cordifolia leaves (AEAC). The antioxidant activity of A. cordifolia leaves was studied in vitro by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals scavenging assay and by the iron reduction ability. A phytochemical screening was carried out to identify the chemical groups that could be responsible for this activity. The hepatoprotective effect was demonstrated in a model of hepatotoxicity induced by isoniazid and rifampicin in rats. Two hours after induction of hepatotoxicity, the animals were orally administered the AEAC at 200 mg/kg, 400 mg/kg, 800 mg/kg for 10 consecutive days. A blood sample was taken on the 11 th day for the evaluation of transaminases, markers of hepatic cytolysis. A totally of 96 rats were used in this study. AEAC showed dose-dependent antioxidant activity. Phytochemical screening revealed the presence of flavonoids, tannins and alkaloids. Administrated alone, aqueous extract of A. cordifolia leaves didn't modificate the transaminases, isoniazid and the isoniazid + rifampicin combination resulted in increasing transaminases (ALT and AST) by more than 48%. AEAC at 800 mg/kg reduced AST and ALT levels by more than 45%. AEAC at 200 mg/kg and 400 mg/kg decreased ALT more than 40%. Knowing that antioxidant activity protects liver, the AEAC may by its antioxidant activity, contribute to protect against the hepatotoxicity induced by an-

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In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals

Abstract: DCSE has contributed to the reduction of oxidative stress and the protection of liver in experimental rats.

Cited by 60 publications

References 19 publications

Nutritional and therapeutic importance of Daucus carota- A review

Nutritional and therapeutic importance of Daucus carota- A review

Hepatoprotective effects of methanol extract of Alchornea cordifolia leaves against anti-tubercular drugs induced hepatotoxicity in rats

Antioxidant Activity and Hepatoprotective Effect of an Aqueous Extract of <i>Alchornea cordifolia</i> Leaves

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In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals

Abstract: DCSE has contributed to the reduction of oxidative stress and the protection of liver in experimental rats.

Cited by 60 publications

References 19 publications

Nutritional and therapeutic importance of Daucus carota- A review

Nutritional and therapeutic importance of Daucus carota- A review

Hepatoprotective effects of methanol extract of Alchornea cordifolia leaves against anti-tubercular drugs induced hepatotoxicity in rats

Antioxidant Activity and Hepatoprotective Effect of an Aqueous Extract of &lt;i&gt;Alchornea cordifolia&lt;/i&gt; Leaves

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Antioxidant Activity and Hepatoprotective Effect of an Aqueous Extract of <i>Alchornea cordifolia</i> Leaves