In vivo anti-obesity efficacy of curcumin loaded nanofibers transdermal patches in high-fat diet induced obese rats

Ariamoghaddam, Amir reza; Ebrahimi-Hosseinzadeh, Bahman; Hatamian-Zarmi, Ashrafalsadat; Sahraeian, Razi

doi:10.1016/j.msec.2018.06.030

Cited by 38 publications

(17 citation statements)

References 32 publications

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“…[45] Curcumin administration via percutaneous absorption in obese rats improved serum leptin levels and reduced adipose tissue volume to a level comparable with that in normal rats. [46]…”

Section: Curcumin Obesity and Diabetesmentioning

confidence: 99%

Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

et al. 2019

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Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time.

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“…[45] Curcumin administration via percutaneous absorption in obese rats improved serum leptin levels and reduced adipose tissue volume to a level comparable with that in normal rats. [46]…”

Section: Curcumin Obesity and Diabetesmentioning

confidence: 99%

Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

et al. 2019

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“…Table 4 lists some of the new anti-obesity agents being studied, as well as their possible mechanisms of action and their delivery methods. Hypodermic injection, transdermal [183,184] Thyroid hormone (T3) [185,186] ROSI Oral administration, transdermal [187,188] Curcumin [189,190] Fucoxanthin Oral administration [191] Bile acid [192] Capsaicin [193] Olive oil [194] GLP1 analogue Hypodermic injection [180] Resveratrol Oral administration [182] Gelatin Fat decomposition…”

Section: Development Of New Anti-obesity Drugsmentioning

confidence: 99%

Transdermal Drug Delivery Systems and Their Use in Obesity Treatment

Fang

2021

IJMS

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Transdermal drug delivery (TDD) has recently emerged as an effective alternative to oral and injection administration because of its less invasiveness, low rejection rate, and excellent ease of administration. TDD has made an important contribution to medical practice such as diabetes, hemorrhoids, arthritis, migraine, and schizophrenia treatment, but has yet to fully achieve its potential in the treatment of obesity. Obesity has reached epidemic proportions globally and posed a significant threat to human health. Various approaches, including oral and injection administration have widely been used in clinical setting for obesity treatment. However, these traditional options remain ineffective and inconvenient, and carry risks of adverse effects. Therefore, alternative and advanced drug delivery strategies with higher efficacy and less toxicity such as TDD are urgently required for obesity treatment. This review summarizes current TDD technology, and the main anti-obesity drug delivery system. This review also provides insights into various anti-obesity drugs under study with a focus on the recent developments of TDD system for enhanced anti-obesity drug delivery. Although most of presented studies stay in animal stage, the application of TDD in anti-obesity drugs would have a significant impact on bringing safe and effective therapies to obese patients in the future.

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“…The results indicated that the volume percentage of adipose tissue in the treated group decreased significantly (4–7%), compared to the obese animals (Figure 8D‐III). [ 318 ]…”

Section: Applicationsmentioning

confidence: 99%

Drug‐Eluting Medical Textiles: From Fiber Production and Textile Fabrication to Drug Loading and Delivery

Rostamitabar

Abdelgawad

Jockenhoevel

et al. 2021

Macromolecular Bioscience

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Drug-eluting medical textiles have recently gained great attention to be used in different applications due to their cost effectiveness and unique physical and chemical properties. Using various fiber production and textile fabrication technologies, fibrous constructs with the required properties for the target drug delivery systems can be designed and fabricated. This review summarizes the current advances in the fabrication of drug-eluting medical textiles. Different fiber production methods such as melt-, wet-, and electro-spinning, and textile fabrication techniques such as knitting and weaving are explained. Moreover, various loading processes of bioactive agents to obtain drug-loaded fibrous structures with required physicochemical and morphological properties, drug delivery mechanisms, and drug release kinetics are discussed. Finally, the current applications of drug-eluting fibrous systems in wound care, tissue engineering, and transdermal drug delivery are highlighted.

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In vivo anti-obesity efficacy of curcumin loaded nanofibers transdermal patches in high-fat diet induced obese rats

Cited by 38 publications

References 32 publications

Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

Transdermal Drug Delivery Systems and Their Use in Obesity Treatment

Drug‐Eluting Medical Textiles: From Fiber Production and Textile Fabrication to Drug Loading and Delivery

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