Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

Shimizu, Kana; Funamoto, Masafumi; Sunagawa, Yoichi; Shimizu, Satoshi; Miyazaki, Yusuke; Wada, Hiromichi; Hasegawa, Koji; Morimoto, Tatsuya

doi:10.15420/ecr.2019.17.2

Cited by 70 publications

(45 citation statements)

References 69 publications

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“…Its anti-inflammatory effect which is equivalent to that of steroidal and nonsteroidal drugs, e.g., indomethacin and phenylbutazone, is one of the most studied properties [ 8 , 12 ]. In various inflammation-related chronic illnesses such as cardiovascular disease, cancer, diabetes, and obesity, curcumin has shown good therapeutic effects [ 13 ]. The pivotal role of inflammation in the pathogenesis of atherosclerosis has been documented.…”

Section: Resultsmentioning

confidence: 99%

Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway

Zhang

Liu

Pang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.

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Section: Resultsmentioning

confidence: 99%

Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway

Zhang

Liu

Pang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Polyphenols like curcumin, capsaicin, apigenin, oleandrin, quercetin, resveratrol, cinnamaldehyde, epigallocatechin-3-gallate, etc. are well known for their anti-inflammatory properties [ 194 , 195 , 196 ] and mostly act through arachidonic acid dependent and independent pathways. While the former involves COX, the latter is generally mediated through NF-κB.…”

Section: Molecules That Can or May Be Repurposed As Nf-κb Pathway mentioning

confidence: 99%

Small Molecule NF-κB Pathway Inhibitors in Clinic

Ramadass

Vaiyapuri

Tergaonkar

2020

IJMS

126

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Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases, with its role in transcription of hundreds of gene well established in the literature. This has propelled research into targeting the NF-κB pathways for modulating expression of those genes and the diseases mediated by them. In-spite of the critical, but often promiscuous role played by this pathway and the inhibition causing adverse drug reaction, currently many biologics, macromolecules, and small molecules that modulate this pathway are in the market or in clinical trials. Furthermore, many marketed drugs that were later found to also have NF-κB targeting activity were repurposed for new therapeutic interventions. Despite the rising importance of biologics in drug discovery, small molecules got around 76% of US-FDA (Food and Drug Administration-US) approval in the last decade. This encouraged us to review information regarding clinically relevant small molecule inhibitors of the NF-κB pathway from cell surface receptor stimulation to nuclear signaling. We have also highlighted the underexplored targets in this pathway that have potential to succeed in clinic.

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“…Several preclinical and clinical studies have proposed that the route of curcumin administration is an important factor in terms of its serum and tissue levels [ 138 ]. Curcumin-loaded polymer nanoparticle systems are therefore intensively studied [ 139 , 140 ].…”

Section: Therapeutic Effects Of Polyphenols-loaded Polymeric Nanopmentioning

confidence: 99%

Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

2020

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Numerous studies document an increased production of reactive oxygen species (ROS) with a subsequent decrease in nitric oxide (NO) bioavailability in different cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. Many natural polyphenols have been demonstrated to decrease ROS generation and/or to induce the endogenous antioxidant enzymatic defense system. Moreover, different polyphenolic compounds have the ability to increase the activity/expression of endothelial nitric oxide synthase (eNOS) with a subsequent enhancement of NO generation. However, as a result of low absorption and bioavailability of natural polyphenols, the beneficial effects of these substances are very limited. Recent progress in delivering polyphenols to the targeted tissues revealed new possibilities for the use of polymeric nanoparticles in increasing the efficiency and reducing the degradability of natural polyphenols. This review focuses on the effects of different natural polyphenolic substances, especially resveratrol, quercetin, curcumin, and cherry extracts, and their ability to bind to polymeric nanoparticles, and summarizes the effects of polyphenol-loaded nanoparticles, mainly in the cardiovascular system.

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Anti-inflammatory Action of Curcumin and Its Use in the Treatment of Lifestyle-related Diseases

Cited by 70 publications

References 69 publications

Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway

Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway

Small Molecule NF-κB Pathway Inhibitors in Clinic

Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System

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