Drug‐Eluting Medical Textiles: From Fiber Production and Textile Fabrication to Drug Loading and Delivery

Abstract

Drug-eluting medical textiles have recently gained great attention to be used in different applications due to their cost effectiveness and unique physical and chemical properties. Using various fiber production and textile fabrication technologies, fibrous constructs with the required properties for the target drug delivery systems can be designed and fabricated. This review summarizes the current advances in the fabrication of drug-eluting medical textiles. Different fiber production methods such as melt-, wet-, and electro-spinning, and textile fabrication techniques such as knitting and weaving are explained. Moreover, various loading processes of bioactive agents to obtain drug-loaded fibrous structures with required physicochemical and morphological properties, drug delivery mechanisms, and drug release kinetics are discussed. Finally, the current applications of drug-eluting fibrous systems in wound care, tissue engineering, and transdermal drug delivery are highlighted.

Facile fabrication of an extended‐release tablet of Ticagrelor using three dimensional printing technology

“…The in vitro release data was fitted by Korsemeyer–Peppas, and zero‐order model as reported in the literature. To study the release kinetics, data obtained from in vitro drug release studies were plotted as log cumulative percentage drug release versus log time 57–59 …”

“…To study the release kinetics, data obtained from in vitro drug release studies were plotted as log cumulative percentage drug release versus log time. [57][58][59] Additionally, in the same condition, a dissolution study of Ticagrelor from the neat drug and 3D printed tablet was performed in acidic media of HCL 0.1N, pH 1.2 in the presence and absence of 0.2% polysorbate for 2 h.…”

State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applications

“…Biotextiles are one broad type of medical devices/materials with given textile structures and patterns and are used in specific biological environments, depending on their biocompatibility and biostability with cells and biological fluids. Biotextiles commonly include engineered textile scaffolds and implants [1] , textile-based drug delivery carriers [2] , hygiene textiles [3] , and wearable bioelectronic devices [4] . For instance, the medical face masks are one typical biotextile, which are widely utilized to stop the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the COVID-19 pandemic.…”

Drug loaded cellulose–chitosan aerogel microfibers for wound dressing applications

“…Moreover, the advanced wound care market aiming for surgical wounds and chronic ulcers is expected to exceed $22 billion by 2024 (Sen 2019). Medical textile plays an important role in wound dressings, and such a continuing rise in the need for wounds products requires the fabrication of sustainable added-value products originating from renewable materials such as cellulose and chitosan (McQueen 2011;Rostamitabar et al 2021a). Cellulose, the most abundant biopolymer present in plant cell walls, is made of β-D-glucose held by β-1, 4-glycosidic linkages (French 2017).…”

“…Aerogels are produced from wet gels in delicate drying processes such as freeze-drying or supercritical CO 2 (scCO 2 ) so that the gel structure is merely conserved. In contrast to other drying techniques, scCO 2 is a mild temperature process that leads to better textural properties as well as sterilization (Ribeiro et al 2020) and drug loading possibilities of fabricated aerogels (Rostamitabar et al 2021a). Drug impregnation in the aerogel fibers can be performed either during gel preparation or during the network formation (solvent exchange) or after drying the aerogel through the post-treatment method which utilizes scCO 2 as a medium to dissolve and impregnate the drug (Ulker and Erkey 2014).…”