In vitro-Untersuchungen mit Poliomyelitisviren unter Dehydro-Cortisol-Einfluß

Goetz, O; Bornschein, W

doi:10.1007/bf02157422

Cited by 2 publications

(3 citation statements)

References 51 publications

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“…Wir fiihr~en den Test nach der friiher yon uns angegebenen Me,bode [8] durch. Das FITC-Antim~use-IgG yon der Firma Hyland verwendeten wir in einer Gebrauchsverdiinnung yon 1 : 5.…”

Section: Immunofluorescenztestunclassified

Immunsuppression und Cytomegalievirusinfektion

Peller

Goetz

1974

Res. Exp. Med.

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Cytomegalovirus infections are very dangerous for patients receiving an immunosuppressive therapy. Therefore, we investigated the influence of the immunsuppression, induced by cyclophosphamid onto the course of the infections with murine cytomegalovirus in mice.The disease is a suitable model for the investigation in animal experiments since many problems in human cytomegalo infections are unsolved due to the species specifity of the virus.Virus-infected NMRI mice without cyclophosphamid pretreatment showed no symptoms of the disease, cytomcgalie hepatitis was minimal and short lasting, and the mortality was 1%. All animals pretreated with cyclophosphamid and infected with the virus got sick, the mortality rate being high. After a single dose of 80 mg cyclophosphamid per kilogram body weight the mortality was 48%, after 3 doses of 80 mg/kg given prior to the infection, it was 84%. The infection of the liver lastet longer in all prctreated animals. The virus isolation was 70 times as high in animals given one dose of cyclophosphamid, and 570 times as high in those given 3 doses compared t~ animals without pretrcatment.Our experiments show clearly that even a single dose of eyclophosphamid is able to elevate the risk of infection during the immunsuppressive action, and that a relation exists between ~he effectivity of immunsuppression, mortality rate and virus multiplicatiou.

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“…Wir fiihr~en den Test nach der friiher yon uns angegebenen Me,bode [8] durch. Das FITC-Antim~use-IgG yon der Firma Hyland verwendeten wir in einer Gebrauchsverdiinnung yon 1 : 5.…”

Section: Immunofluorescenztestunclassified

Immunsuppression und Cytomegalievirusinfektion

Peller

Goetz

1974

Res. Exp. Med.

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“…Die Immunofluorescenz nach Coons und Kaplan fiihrten wir nach der yon uns frfiher angegebenen Methodik durch [5].…”

Section: Immunofluorescenzunclassified

“…Fiir die Versuche verwendeten wit entweder Konjugate nach der frtiher mitgeteilten Methode [5] oder Konjugate der Firms Flow.…”

Section: Antimeerschweinchen Y-globulin-kon]ugatunclassified

Immunofluorescence-microscopy in measles

1971

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Abstract. In 79 children who contracted measles the attempt was made to find the virus in epithelium cells of a buccal smear at different stages of the disease by the help of immunofluorescence. In 42 children (52O/o) this was successful. The test was always positive during the prodromal phase, frequently positive during the first and second day of the rash, but from the fifth day on no virus could be detected any more. In children who fell ill otherwise the test was invariably negative. It is suggested that immunofluorescence-microscopy is a rapid and reliable method for the establishment of the diagnosis of measles during the prodromal phase.

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In vitro-Untersuchungen mit Poliomyelitisviren unter Dehydro-Cortisol-Einfluß

Cited by 2 publications

References 51 publications

Immunsuppression und Cytomegalievirusinfektion

Immunsuppression und Cytomegalievirusinfektion

Immunofluorescence-microscopy in measles

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