“…Increasing proportions of circulating strains of gonococci less sensitive to penicillin have been noted in most parts of the world. In many areas, for example, the USA (Martin et al , 1969) and the United Kingdom (Wilkinson, 1971) the rise has been gradually progressive although the upper limit of resistance in London remains about the same as in 1957 (Wilkinson, 1971). The degree of resistance varies geographically and as regards time, being more marked in the Far East — particularly in relation to the war zones — and in Africa, while it is least marked in Northern Europe (Table II).…”