1973
DOI: 10.1093/infdis/128.2.178
|View full text |Cite
|
Sign up to set email alerts
|

Nutritional Profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in Chemically Defined Media and the Use of Growth Requirements for Gonococcal Typing

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
10
0

Year Published

1984
1984
2018
2018

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 298 publications
(10 citation statements)
references
References 42 publications
0
10
0
Order By: Relevance
“…Contrary to α522, the growth of MC58 was slightly suppressed by these two amino acids. The ability of MC58 but not α522 to grow in the absence of Cys and Gln indicates strain specific differences in the respective metabolic pathways, and the requirement of some meningococcal strains for Cys and its growth inhibiting effect on others has already been reported [60]. In parallel with these phenotypic differences, genome comparisons revealed also striking differences in Cys and Gln biosynthesis genes that might contribute to the phenotypic finding, although the repertoire of enzymes required for the biosynthesis of amino acids is otherwise highly conserved in both genomes.…”
Section: Resultsmentioning
confidence: 94%
“…Contrary to α522, the growth of MC58 was slightly suppressed by these two amino acids. The ability of MC58 but not α522 to grow in the absence of Cys and Gln indicates strain specific differences in the respective metabolic pathways, and the requirement of some meningococcal strains for Cys and its growth inhibiting effect on others has already been reported [60]. In parallel with these phenotypic differences, genome comparisons revealed also striking differences in Cys and Gln biosynthesis genes that might contribute to the phenotypic finding, although the repertoire of enzymes required for the biosynthesis of amino acids is otherwise highly conserved in both genomes.…”
Section: Resultsmentioning
confidence: 94%
“…8A), indicating that the growth of the cbp mutant was not defective in liquid medium. In previous experiments using meningococcal defined medium, Neisseria chemically defined medium (NCDM), developed by Catlin (30), was commonly used for N. meningitidis (31, 34).…”
Section: Resultsmentioning
confidence: 99%
“…Experimental data has indicated that many N. meningitidis strains are auxotrophs for at least 4 amino acids, namely, glutamate, cysteine, arginine, and glycine (30), and previous studies also demonstrated that glutamate uptake is required for bacterial intracellular growth/survival in human cells (3133) as well as for survival and proliferation in mice (34, 35). Moreover, a reduced sulfur form of cysteine, cystine, was found to be necessary for meningococcal growth (36, 37), and many N.…”
Section: Introductionmentioning
confidence: 99%
“…When needed, rifampin (Sigma-Aldrich) was added to a final concentration of 36 g/ml. Meningococci were also cultured in the chemically defined medium MCDA (24,25) with different sodium ion concentrations [Na ϩ ]: 21.6 mM (MCDA-1), 41.6 mM, 61.6 mM (MCDA-2), 101.6 mM, and 121.6 mM (26). The pH of all media was adjusted to 7.4.…”
Section: Methodsmentioning
confidence: 99%