In vitro study on novel bioactive peptides with antioxidant and antihypertensive properties from edible rhizomes

Sompinit, Kamonwan; Lersiripong, Supatsorn; Reamtong, Onrapak; Pattarayingsakul, Werawich; Patikarnmonthon, Nisa; Panbangred, Watanalai

doi:10.1016/j.lwt.2020.110227

Cited by 22 publications

(16 citation statements)

References 29 publications

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“… Enzymatic hydrolysis by pepsin and trypsin Antioxidant evaluated by DPPH (EC 50 = 19.9 μmol/L for VTYM), and ABTS (EC 50 = 24.0 μmol/L for VTYM), and ACE-inhibition (IC 50 = 16.4, 18.3, 19.0, and 25.0 μmol/L for VTYM, CGVGAA, DVDP, and CACGGV, respectively). Sompinit, Lersiripong, Reamtong, Pattarayingsakul, Patikarnmonthon, & Panbangred, 2020 Edible insects Schistocerca gregaria FDPFPK Baked and in vitro enzymatic digestion Antioxidant evaluated by DPPH (EC 50 = 0.35 mg/mL), ABTS (EC 50 = 0.08 mg/mL), and anti-inflammatory by lipoxygenase inhibitory activity (LOX, IC 50 = 2.85 mg/mL) and Cyclooxygenase 2 inhibitory activity (COX 2, IC 50 = 7.40 mg/mL). Zielińska, Baraniak, & Karas, 2018.…”

Section: Common and Non-conventional Sources Of Bioactive Peptidesmentioning

confidence: 99%

Conventional and in silico approaches to select promising food-derived bioactive peptides: A review

et al. 2022

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Section: Common and Non-conventional Sources Of Bioactive Peptidesmentioning

confidence: 99%

Conventional and in silico approaches to select promising food-derived bioactive peptides: A review

et al. 2022

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“…Recently, numerous antihypertensive peptides are isolated from different food sources such as milk [ 80 ], casein [ 81 , 82 ], egg white ovotransferrin [ 22 ], rice bran [ 1 ], wheat [ 83 ], soybean [ 84 ], potato [ 85 ], turmeric and ginger [ 9 ], quinoa [ 62 ], black cumin [ 86 ], coix [ 87 ], pistachio [ 88 ], hazelnut [ 89 ], mung bean [ 90 ], lentil [ 91 ], seahorse [ 92 ], egg white from ostrich [ 93 ], chum salmon [ 94 ], skate [ 95 ], cuttlefish [ 96 ], Sipuncula [ 97 ], bighead carp [ 98 ], shrimp ( Pandalus borealis ) [ 79 ], and beef [ 99 ]. The isolated dietary protein-derived peptides have been demonstrated to exhibit antihypertensive activities through influencing various molecular mechanisms including inhibition of angiotensin-converting enzyme (ACE), reduction of SBP, decrease of angiotensin II levels and AT1R expression, enhancing vasodilation, improving central blood pressure and arterial stiffness, and inhibition of vasoconstriction via PPAR- γ expression [ 9 , 79 , 84 , 90 ]. Table 4 shows the molecular mechanisms of antihypertensive peptides isolated from various dietary sources.…”

Section: The Role Of Dietary Bioactive Peptides In Hypertensionmentioning

confidence: 99%

“…Most dietary ACE inhibitory peptides contained 3–15 AA residues. Recently, several peptides have been isolated with ACE inhibitory activity from numerous dietary sources such as milk [ 80 ], casein [ 82 ], egg white [ 93 ], soybean [ 84 ], rice bran [ 1 ], wheat [ 83 ], pistachio [ 88 ], potato and rapeseed [ 85 ], turmeric and ginger [ 9 ], quinoa [ 62 ], black cumin [ 86 ], hazelnut [ 89 ], lentil [ 91 ], seahorse [ 92 ], chum salmon [ 94 ], skate [ 95 ], cuttlefish [ 96 ], Sipuncula [ 97 ], bighead carp [ 98 ], and beef [ 99 ].…”

Section: The Role Of Dietary Bioactive Peptides In Hypertensionmentioning

confidence: 99%

“…Several commercial proteases, namely, thermolysin, bromelain, trypsin, alcalase, papain, pepsin, neutrase, pancreatin, corolase, protamex, and pronase, have been employed to generate biologically active peptides from various dietary proteins. Among the above-mentioned proteases, alcalase, trypsin, pepsin, and pancreatin are the most widely used proteases for the preparation of peptides, with various health benefitting properties, from numerous food sources [7][8][9][10]. These enzymes are routinely used due to their broad specificity to produce smaller peptides with various bioactivities and easily availability.…”

Section: Introductionmentioning

confidence: 99%

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Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders

Qiao

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Bioactive peptides (BPs) are fragments of 2–15 amino acid residues with biological properties. Dietary BPs derived from milk, egg, fish, soybean, corn, rice, quinoa, wheat, oat, potato, common bean, spirulina, and mussel are reported to possess beneficial effects on redox balance and metabolic disorders (obesity, diabetes, hypertension, and inflammatory bowel diseases (IBD)). Peptide length, sequence, and composition significantly affected the bioactive properties of dietary BPs. Numerous studies have demonstrated that various dietary protein-derived BPs exhibited biological activities through the modulation of various molecular mechanisms and signaling pathways, including Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element in oxidative stress; peroxisome proliferator-activated-γ, CCAAT/enhancer-binding protein-α, and sterol regulatory element binding protein 1 in obesity; insulin receptor substrate-1/phosphatidylinositol 3-kinase/protein kinase B and AMP-activated protein kinase in diabetes; angiotensin-converting enzyme inhibition in hypertension; and mitogen-activated protein kinase and nuclear factor-kappa B in IBD. This review focuses on the action of molecular mechanisms of dietary BPs and provides novel insights in the maintenance of redox balance and metabolic diseases of human.

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“…Their investigation revealed that the mechanism of the hypotensive nature of the extract was a result of blocking calcium ion channels. Sompinit et al (2020) reported antihypertensive activity of peptides from crude hydrolysate of ginger.…”

Section: Zingiber Officinalementioning

confidence: 99%

A review of some common African spices with antihypertensive potential

Adeoye

Joel

Igunnu

et al. 2021

Journal of Food Biochemistry

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Hypertension is the most common non-communicable disease, with about 1.28 billion hypertensive people worldwide. It is more prevalent in men than women and more common in the elderly. Hereditary, age, obesity, lifestyle, diet, alcohol, and chronic metabolic diseases are the major risk factors of hypertension. Treating hypertension is a complex process as there are several mechanisms responsible for its pathogenesis; hence, a combination of several drugs is used for managing hypertension. Drugs used in managing hypertension are expensive and often come with associated side effects; thus, there is need for alternative means of managing this life-threatening disease. These drugs do not achieve the recommended blood pressure target in most people; more so majority of people with hypertension do not follow the treatment regimen religiously. Some Africans have been reported to become normotensive as a result of dietary consumption of spices. Several spices have been used over the years in Africa to manage hypertension. The aim of this review is to evaluate the ethnomedicinal use, bioactive phytochemical composition, bioactive compounds present, and pharmacological applications of spices commonly used in Africa for managing hypertension. Most of the plants used contained polyphenols, flavonoids, tannins, anthraquinone, flavonoids, cardiac glycosides, and saponins. Dietary supplementation of Xylopia aethiopica and other spices in diet have been proven to significantly reduced plasma angiotensin-I-converting enzyme (ACE) than simvastatin (the reference drug). Toxicological, histological, and hematological evaluation revealed that acute and chronic consumption of most of these spices are safe. Studies have also revealed that some of the spices can be used as alternative therapy alongside usual antihypertensive medications. Practical implication:The prevalent rate of hypertension is on the increase in both the developed and developing countries. People often skip medication due to their busy schedule and anti-hypertensive potential side effects; however, this is not the case with food/spices as most people consumed them daily. Deliberate, right combinations and consistent incorporation of spices with proven anti-hypertensive potential into our diet may be of great benefit in normalizing blood pressure and mitigate other complications on the heart and vital organs.Hypertension or elevated blood pressure means the persistent force of blood against the artery wall leading to increase in blood pressure. According to World Health Organisation (WHO, 2021), blood pressure on two different days with both days exceeding 140/90 mmHg is classified as hypertension. The first (higher) number is the systolic, which is the blood pressure when the heart contracts, while the second (lower number) is the diastolic, which is the blood pressure when the heart relaxes (Ondimu et al., 2019). It is usually measured using upper arm cuff; however wrist devices are used for obese persons with extreme size of the arm (Nerenberg et al., 2018). Accordi...

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In vitro study on novel bioactive peptides with antioxidant and antihypertensive properties from edible rhizomes

Cited by 22 publications

References 29 publications

Conventional and in silico approaches to select promising food-derived bioactive peptides: A review

Conventional and in silico approaches to select promising food-derived bioactive peptides: A review

Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders

A review of some common African spices with antihypertensive potential

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