In vitro Screening of Asteraceae Plant Species Against Trypanosoma cruzi

In vitro evaluation of trypanocidal activity in plants used in Argentine traditional medicine

“…Another criterion for selection included species belonging to the family Asteraceae (E. buniifolium and B. spicata) with precedent of antiprotozoal activity (Chiari et al 1996) or species with potential bioactive antiprotozoal compounds such as mulinane-type diterpenoids, as is the case for M. spinosum (Araya et al 2003;Loyola et al 2004). …”

“…Compounds of this type, isolated from genus Lychnophora, showed trypanocidal activities. Chiari et al 1996). From B. spicata bioactive neo-clerodane diterpenes toward Tenebrio molitor larvae were isolated (Gallardo et al 1996).…”

Trypanocidal activity of coumarins and styryl-2-pyrones from Polygala sabulosa A.W. Bennett (Polygalaceae)

“…In the search for new chemoprophylatic agents for Chagas disease, Chiari et al (1996) studying ethanol extracts from 47 Asteraceae species showed that 11 extracts reduced by 100% blood trypomastigotes in vitro at a concentration of 12 mg/mL. Zani et al (1995) evaluating trypanocidal activity of ethanol extracts of 52 Asteraceae species showed that 10% of them reduced by 70% the number blood trypomastigotes in vitro at a concentration of 250 μg/mL.…”

Screening of Southeastern BrazilianMikania. Species onTrypanosoma cruzi.

“…In the research about the trypanocidal effects of plants, we decided to verify the trypanocidal activity of M.hoehnei, M. stipulacea, M. cordifolia, M. camporum, M. lasiandrae, and M. micrantha, considering that extracts as well as pure compounds obtained from the Asteraceae family have been reported to possess significant trypanocidal activity (Chiari et al, 1996;Muelas-Serrano et al, 2000;Taleb-Contini et al, 2004). In this study, the trypanocidal activity of 14 extracts of plants of the Mikania genus was evaluated against the trypomastigote forms of T. cruzi Y strain.…”

“…The species M. cordifolia had already been tested by Chiari et al (1996), Muelas-Serrano et al (2000), and Rojas de Arias et al (1995), however, different solvents and concentrations were used.…”