A study of the trypanocidal and analgesic properties from Lychnophora granmongolense (Duarte) Semir &amp; Leit�o Filho

Grael, Cristiane Fernanda Fuzer; Vichnewski, Walter; Souza, Glória Emília Petto de; Lopes, João Luís Callegari; Albuquerque, Sérgio de; Cunha, Wilson Roberto

doi:10.1002/(sici)1099-1573(200005)14:3<203::aid-ptr565>3.0.co;2-r

Cited by 58 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This activity was initially proposed due to the presence of sesquiterpene lactones. 30 However, Grael and co-workers 31 reported that extracts of the aerial parts of Lychnophora granmongolense showed no analgesic activity in the writhing model of pain, even though the STLs goyazensolide (84) and centratherin (92) were isolated from those extracts. These results, in combination with those obtained for the L. salicifolia extracts, 32 suggested that not all the Lychnophora species could exhibit analgesic activity correlated to the accumulation of sesquiterpene lactones.…”

Section: Proteopsis Furnensismentioning

confidence: 99%

Lychnophorinae (asteraceae): a survey of its chemical constituents and biological activities

Keles¹,

Melo²,

Aguiar³

et al. 2010

Quím. Nova

Self Cite

View full text Add to dashboard Cite

. do Café, s/n, 14040-903 Ribeirão Preto -SP, BrasilRecebido em 1/7/10; aceito em 21/9/10; publicado na web em 27/10/10 LYCHNOPHORINAE (ASTERACEAE): A SURVEY OF ITS CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES. This work reviews the current literature about the chemical constituents and the biological activities of the subtribe Lychnophorinae (Vernonieae, Asteraceae). The notable secondary metabolites are sesquiterpene lactones of furanoheliangolide (goyazensolide and eremantholide types) and flavonoids. Some of its most investigated activities include its anti-inflammatory, analgesic, antimicrobial and cytotoxic activities, specially for the Lychnophora and Eremanthus species. The data presented on this paper not only displayed the role played by the Lychnophorinae species as a source of bioactive compounds, but also reinforced the need of further studies involving the species of such subtribe.

show abstract

Section: Proteopsis Furnensismentioning

confidence: 99%

Lychnophorinae (asteraceae): a survey of its chemical constituents and biological activities

Keles¹,

Melo²,

Aguiar³

et al. 2010

Quím. Nova

Self Cite

View full text Add to dashboard Cite

show abstract

“…The NOEDIFF experiments confirmed all relative stereochemistry for each structure and some previously ambiguous carbon assignments were also clarified. C NMR data for centratherin (2). 500MHz, CDCl 3 …”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3][4][5] Their structures show significant variety and complexity, making structural elucidation a challenge. Since the first articles on isolation and identification of SL were published in the early 1960s, some published data has proven incomplete, inaccurate or even wrong, due to equipment limitations at the time.…”

Section: Introductionmentioning

confidence: 99%

Complete ¹H and 13C NMR structural assignments for a group of four goyazensolide-type furanoheliangolides

et al. 2012

View full text Add to dashboard Cite

show abstract

“…It showed an IC50 of 3.57 and 8.06 µg/mL (Table 1) against U87-MG and U251 cell lines, respectively. Furanoheliangolides often exhibit antiinflammatory, trypanocidal, cytotoxic, and genotoxic activities (Grael et al, 2000;Sakamoto et al, 2003;Santos et al, 2004;Vasconcelos et al, 2007;). The furanoheliangolides possess two functionalities in the form of an α-methylene-γ-lactone and an α,β,γ,δ unsaturated carbonyl group (Rüngeler et al, 1999) that can react through a stereospecific Michael addition with biological nucleophiles (mainly with the thiol groups of cysteine residues present in proteins) forming stable adducts (Ghantous et al, 2010).…”

Section: Ms/ms Analysis (mentioning

confidence: 99%

Antiproliferative activity of Eremanthus crotonoides extracts and centratherin demonstrated in brain tumor cell lines

Lobo¹,

Castro²,

Gouvea

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Abstract:The genus Eremanthus is recognized by the predominance of sesquiterpene lactones from the furanoheliangolide type, a class of substances extensively tested against cancer cell lines. Thus, the species E. crotonoides (DC.) Sch. Bip., Asteraceae, obtained on "restinga" vegetation was evaluated against U251 and U87-MG glioma cell lines using the MTT colorimetric assay. Dichloromethane fraction was cytotoxic to both glioblastoma multiforme cell lines. We then conducted UPLC-PDA-ESI-MS/MS analysis of the dichloromethane fraction, which allowed the identification of the sesquiterpene lactones centratherin and goyazensolide. The isolation of centratherin was performed using chromatographic techniques and the identification of this substance was confirmed according to NMR data. Cytotoxic activity of centratherin alone was also evaluated against both U251 and U87-MG cells, which showed IC50 values comparable with those obtained for the commercial anticancer drug doxorubicin. All the tested samples showed cytotoxic activity against glioblastoma multiforme cells which suggests that E. crotonoides extracts may be important sources of antiproliferative substances and that the centratherin may serve as prototype for developing new antiglioblastoma drugs.

show abstract

A study of the trypanocidal and analgesic properties from Lychnophora granmongolense (Duarte) Semir & Leit�o Filho

Cited by 58 publications

References 21 publications

Lychnophorinae (asteraceae): a survey of its chemical constituents and biological activities

Lychnophorinae (asteraceae): a survey of its chemical constituents and biological activities

Complete ¹H and 13C NMR structural assignments for a group of four goyazensolide-type furanoheliangolides

Antiproliferative activity of Eremanthus crotonoides extracts and centratherin demonstrated in brain tumor cell lines

Contact Info

Product

Resources

About