Lychnophorinae (asteraceae): a survey of its chemical constituents and biological activities

Abstract

. do Café, s/n, 14040-903 Ribeirão Preto -SP, BrasilRecebido em 1/7/10; aceito em 21/9/10; publicado na web em 27/10/10 LYCHNOPHORINAE (ASTERACEAE): A SURVEY OF ITS CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES. This work reviews the current literature about the chemical constituents and the biological activities of the subtribe Lychnophorinae (Vernonieae, Asteraceae). The notable secondary metabolites are sesquiterpene lactones of furanoheliangolide (goyazensolide and eremantholide types) and flavonoids. Some of its most investigated activities include its anti-inflammatory, analgesic, antimicrobial and cytotoxic activities, specially for the Lychnophora and Eremanthus species. The data presented on this paper not only displayed the role played by the Lychnophorinae species as a source of bioactive compounds, but also reinforced the need of further studies involving the species of such subtribe.

A new HPLC-DAD-MS/MS method for the simultaneous determination of major compounds in the crude extract of Lychnophora salicifolia Mart. (Brazilian arnicão) leaves: Application to chemical variability evaluation

“…Comparison with the fragmentation profiles of chlorogenic acids described in the literature supported our identification of this type of compound [25][26][27][28]. As for the other compounds present in the evaluated extract, accurate mass data and comparison with previously described standards isolated by our research group were essential for their complete structural elucidation [3,4,12,[29][30][31] (for complete details and access to the original spectra, see supplementary material).…”

“…Chemically, the family Asteraceae is characterized by its great diversity of secondary metabolites, such as monoterpenes, diterpenes, triterpenes, sesquiterpenes, including the sesquiterpene lactones, polyacetylenes, flavonoids, phenolic acids, benzofurans, and coumarins [11]. A recent review on the chemical constituents of the Lychnophorinae tribe has revealed significant variation in the occurrence of secondary metabolites in the genus Lychnophora [12]. Considering a single species, three phenomena can account for the observed differences: (a) accomplishment of a phytochemical investigation looking for a specific class of target secondary metabolites only, such as sesquiterpene lactones [13,14]; (b) performance of bioguided fractionation, which inspects a typical biological activity and may result in the isolation of a common class of secondary metabolites [15][16][17]; and (c) natural chemical variations in metabolism or presence of chemotypes [6][7][8]10].…”

Diversity of non-glandular trichomes in subtribe Lychnophorinae (Asteraceae: Vernonieae) and taxonomic implications

“…Another species group of challenging identification is composed of L. pinaster and the widespread medicinal L. ericoides, the latter being focus of phytochemical investigations (reviewed in Keles et al 2010) and conservation studies (Collevatti et al 2009;Maia-Almeida et al 2012). Leaf characters and geographical distribution are usually used to distinguish these species (Loeuille 2011;Semir et al 2011), but differences in the trichome complement are especially helpful and straightforward: L. ericoides' indument is composed solely of D1 trichomes, whereas in L. pinaster A2 and D4 trichomes are found.…”

Towards new botanical pesticides: the toxic effect of Eremanthus goyazensis (Asteraceae) leaves essential oil against Brevipalpus phoenicis (Acari: Tenuipalpidae)

“…The subtribe had its chemistry recently reviewed, 16 where a variety of sesquiterpenes lactones (SLTs) majority is described. The common phytochemical investigations among Lychnophorinae species from late 1970's [17][18][19][20][21] used to be proceed focusing on the analysis of the medium polarity fractions of leaves extracts, which only afforded non-volatile compounds isolation.…”