In vitro performance of composition-equivalent PLGA microspheres encapsulating exenatide acetate by solvent evaporation

Chandrashekar, Aishwarya; Beig, Avital; Wang, Yan; Schwendeman, Steven P.

doi:10.1016/j.ijpharm.2023.123213

Cited by 4 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Introducing more LAI formulations requires a better understanding of the mechanisms of drug loading and release from LAI formulations. Recent studies on PLGA formulations initiated by the FDA have produced a wealth of information on the nature of PLGA polymers, the impact of PLGA polymer types on the drug releaser properties, the impact of processing parameters on the drug release kinetics, and reverse engineering. − …”

Section: Future Ddssmentioning

confidence: 99%

Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution

Park,

Otte,

2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

Controlled drug delivery technology has matured for more than 70 years, starting from a twice-a-day oral formulation to 6 month long-acting injectable formulations. Further technological advances require superior formulations to treat various diseases more efficiently. Developing future formulations with practical innovations for treating existing and new diseases necessitates our continued efforts to overcome at least three main hurdles. They include (i) drug delivery with reduced side effects, (ii) long-term treatment of chronic diseases, and (iii) the overcoming of biological barriers. Such efforts start with the improved ability to accurately test drug delivery efficacy using proper controls. Future development can be aided by artificial intelligence if used properly. The next revolution of drug delivery systems will be augmented if implementation is given equal weight as discovery. Such a process can be accelerated with the systemic revamp of the research funding structure and cultivating a new generation of scientists who can think differently.

show abstract

Section: Future Ddssmentioning

confidence: 99%

Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution

Park,

Otte,

2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…32–36 Among these, GLP-1 RA-loaded microspheres prepared with biodegradable polymers have been deeply studied in recent decades because of their inherent advantages such as maintaining drug activity, good biocompatibility, and controlled drug release. 45–49 Currently, the unique long-acting GLP-1 RA product for sale is exenatide sustained-release microspheres, Bydureon®. It is prepared using Medisorb® microsphere technology (Alkermes plc.…”

Section: Introductionmentioning

confidence: 99%

A review of recent research and development on GLP-1 receptor agonists-sustained-release microspheres

Gao,

Wei,

2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis

Li,

Lin,

Zhou

et al. 2024

International Journal of Pharmaceutics

View full text Add to dashboard Cite

In vitro performance of composition-equivalent PLGA microspheres encapsulating exenatide acetate by solvent evaporation

Cited by 4 publications

References 47 publications

Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution

Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution

A review of recent research and development on GLP-1 receptor agonists-sustained-release microspheres

Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis

Contact Info

Product

Resources

About