Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis

Li, Wei; Lin, Jie; Zhou, Jie; He, Siqi; Wang, Anqi; Hu, Yingfan; Li, Hanmei; Zou, Liang; Liu, Ya

doi:10.1016/j.ijpharm.2024.123878

Cited by 2 publications

(1 citation statement)

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“…Compared with commercially available copper nanoparticles (Cu-NPs), copper citrate and citric acid, Cu-MOF-1 exhibited better antimicrobial peculiarity, with inhibition rates of 99.3% and 97.9% against S. aureus and Escherichia coli (E. coli), respectively, when a dose of 250 µg•mL −1 was applied. The effect of the Cu-MOF-1/PLA fibrous membranes on S. aureus and E. coli also showed good bactericidal activity, with antibacterial rates of 99.8% and 99.3%, respectively [20,21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus

Wang,

Zhao,

Jing

et al. 2024

Molecules

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As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd2(L)2(bibp)2]n (1) and [Ni(L)(bib)]n (2), where H2L = N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene, bibp = 4,4′-bis(imidazol-1-yl)biphenyl, and bib = 1,3-bis(1-imidazoly)benzene, have been synthesized under solvothermal and hydrothermal condition. Structural clarification was performed through infrared spectrum and single-crystal X-ray diffraction analysis, while thermal analysis and XRD technology were used for the performance assessment of compounds 1 and 2. In addition, antibacterial performance experiments showed that compounds 1 and 2 have certain selectivity in their antibacterial properties and have good antibacterial properties against S. aureus. As the concentration of the compound increases, the inhibitory effect gradually strengthens, and when the concentration of the compound reaches 500 μg/mL and 400 μg/mL, the concentration of the S. aureus solution no longer increases and has been completely inhibited.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus

Wang,

Zhao,

Jing

et al. 2024

Molecules

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Hyaluronic Acid in Nanopharmaceuticals: An Overview

Matalqah,

Lafi,

Asha

2024

CIMB

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Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays a critical role in maintaining skin structure and hydration. Its unique properties make it a valuable component in the field of nanopharmaceuticals. The combination of HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving the delivery and efficacy of drugs. HA-based nanoparticles, including solid lipid nanoparticles, and polymeric nanogels, offer controlled release, enhanced stability, and targeted delivery of therapeutic agents. These innovations significantly improve therapeutic outcomes and reduce side effects, making HA an essential tool in modern medicine. In general, HA-modified liposomes enhance drug encapsulation and targeting, while HA-modified solid lipid nanoparticles (SLNs) provide a solid lipid core for drug encapsulation, offering controlled release and stability. This article provides an overview of the potential applications and recent advancements of HA in nanopharmaceuticals, emphasizing its significant impact on the evolving field of targeted drug delivery and advanced therapeutic strategies. By delving into the unique properties of HA and its compatibility with various therapeutic agents, this review underscores the promising potential of HA in revolutionizing nanopharmaceuticals.

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Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis

Cited by 2 publications

References 52 publications

Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus

Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus

Hyaluronic Acid in Nanopharmaceuticals: An Overview

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