In vitro inhibitory effect of progesterone on extrauterine human smooth muscle

Kumar, Dhirendra

doi:10.1016/s0002-9378(16)35736-2

Cited by 89 publications

(34 citation statements)

References 4 publications

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“…These differences in upper gastrointestinal motility between men and women may be attributed to reduced gastrointestinal smooth muscle contractility caused by female reproductive hormones (16,17). However, we did not find differences in esophageal amplitude contractions or sphincter pressures.…”

Section: Watercontrasting

confidence: 71%

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Gender effects on esophageal motility

Dantas

Ferriolli

Souza

1998

Braz J Med Biol Res

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It has been suggested that there are no gender effects on esophageal motility. However, in previous studies the subjects did not perform multiple swallows and the quantitative features of esophageal contractions were not evaluated. In order to investigate the gender effects on esophageal motility we studied 40 healthy normal volunteers, 20 men aged 37 ± 15 years (mean ± SD), and 20 women aged 38 ± 14 years. We used the manometric method with an eight-lumen polyvinyl catheter and continuous perfusion. The upper and lower esophageal sphincter pressures were measured by the rapid pull-through method. With the catheter positioned with one lumen opening in the lower esophageal sphincter, and the others at 5, 10 and 15 cm above the sphincter, ten swallows of a 5-ml water bolus alternated with ten dry swallows were performed. Statistical analysis was done by the Student t-test and Mann-Whitney test. Gender differences (P<0.05) were observed for wet swallows in the duration of contractions 5 cm above the lower esophageal sphincter (men: 3.7 ± 0.2 s, women: 4.5 ± 0.3 s, mean ± SEM), and in the velocity of contractions from 15 to 10 cm above the lower esophageal sphincter (men: 4.7 ± 0.3 cm/s, women: 3.5 ± 0.2 cm/s). There was no difference (P>0.05) in sphincter pressure, duration and percentage of complete lower esophageal sphincter relaxation, amplitude of contractions, or in the number of failed, multipeaked and synchronous contractions. We conclude that gender may cause some differences in esophageal motility which, though of no clinical significance, should be taken into consideration when interpreting esophageal motility tests.

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Section: Watercontrasting

confidence: 71%

“…In vitro studies demonstrated an inhibitory effect of progesterone on the smooth muscle of ureter, large bowel and stomach (16). Another study also demonstrated the inhibitory effect of progesterone on contractile force in rat gastrointestinal smooth muscle (17).…”

Section: Discussionmentioning

confidence: 91%

Gender effects on esophageal motility

Dantas

Ferriolli

Souza

1998

Braz J Med Biol Res

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“…In the group formed by patients, we tried to control the variables already mentioned in the literature. Although there are controversies, it seems gastric emptying is slower in women than men 11,12 , because feminine sexual hormones have an inhibitor role in gastric motility 13 . With menopause, this effect disappears and gastric emptying rates in both genders tend to be the same 14 .…”

Section: Discussionmentioning

confidence: 99%

Estudo do esvaziamento gástrico por cintilografia em pacientes com insuficiência renal crônica

Hirata¹,

Mesquita²,

Filho³

et al. 2012

Rev. Bras. Anestesiol.

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“…Some have attributed these changes to effects of progesterone or chorionic gonadotropin. 19 From a pharmacological basis, metoclopramide appears to address these specific issues by promoting upper gastrointestinal tract motility, relaxing the pyloric sphincter and duodenal bulb, and increasing the lower esophageal sphincter tone.…”

Section: Significancementioning

confidence: 99%

Comparison of Three Outpatient Regimens in the Management of Nausea and Vomiting in Pregnancy

2003

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Objective:This study compares pyridoxine-metoclopramide combination therapy to prochlorperazine and promethazine monotherapies in the outpatient treatment of nausea and vomiting in pregnancy. Study Design:In total, 174 first trimester, singleton pregnancies were evaluated for nausea and vomiting. Patients were prospectively randomized into three treatment groups: pyridoxine-metoclopramide, prochlorperazine, or promethazine. Prior to, and on the third day, patients recorded their subjective responses to the given treatment and their number of emesis episodes. The three treatment groups were compared for therapy response. Results:There were no differences in the number of emesis episodes prior to treatment. Both subjective and objective responses to treatment differed among the three groups when comparing the combination therapy to the monotherapies (p<0.05). Conclusion:Combination therapy with pyridoxine and metoclopramide appears to be superior to either monotherapy in the treatment of nausea and vomiting in pregnancy.

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In vitro inhibitory effect of progesterone on extrauterine human smooth muscle

Cited by 89 publications

References 4 publications

Gender effects on esophageal motility

Gender effects on esophageal motility

Estudo do esvaziamento gástrico por cintilografia em pacientes com insuficiência renal crônica

Comparison of Three Outpatient Regimens in the Management of Nausea and Vomiting in Pregnancy

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