In vitro inhibition of yeast phenylalanyl-tRNA synthetase by ochratoxin A

Immunosuppressive effects of Ochratoxin a in young Turkeys1

“…CMI responses were depressed, confirming the suggestion of Chang et al (1981) that OA caused impaired immune function and perhaps explaining the increased incidence of air-sacculitis in natural disease outbreaks of ochratoxicosis in turkeys (Hamilton et al, 1982). Creppy et al (1979) suggested that the immunosuppressive effects of OA might be due to an inhibition of protein synthesis. Campbell et al (1983) noted lymphocytopaenia and a significant depression in bursal weight and complement activity in fowls treated with both O A and aflatoxin.…”

Immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-contaminated feed

“…phenylalanine, resulting in an inhibition of protein synthesis (due to a competition for the specific tRNA; Creppy et al, 1979). Most recently, Stoev (2010) hypothesized these effects on tRNA, apart from being an underlying basis for their earlier observation of OTA effects on vaccinal immunity in exposed (at levels of 130, 305, and 790 µg OTA/kg diet) broiler chicks (Stoev et al, 2000), might also be a basis for the reduced egg production manifest by hens exposed to OTA-contaminated feeds (1-5 mg OTA/kg diet) for up to 1 year.…”

Effects of ochratoxin a on some production traits, lipid peroxide and glutathione redox status of weaned piglets

“…Among the components of the antioxidant defence system, the lower activity of glutathione peroxidase in the liver and kidney also confirms the presence of oxidative stress caused by OTA. Another explanation of this finding might be the impairment of protein synthesis as a well-known effect of OTA (Creppy et al, 1979). Although this trial did not include a histopathological examination, the non-significant changes found in the glutathione peroxidase activity of the blood plasma possibly mean that the moderate amount of OTA in the feed did not cause marked damage in the kidney, because blood plasma glutathione peroxidase is synthesised in the tubular epithelial cells (Avissar et al, 1994).…”

“…The toxicity of ochratoxin is related to its binding to specific receptors for organic ion transporters of the renal tubular cells (Marquardt and Frohlich, 1992). Ochratoxin A also inhibits protein synthesis (Creppy et al, 1979) and stimulates lipid peroxidation in vitro (Rahimtula et al, 1988) and in vivo in chicken and rat (Hoechler et al, 1997) and consequently enhances DNA adduct formation (Grosse et al, 1997) and apoptosis in the rat kidney (Petrik et al, 2003) in a dose-dependent manner (Omar et al, 1990).…”