Effects of ochratoxin a on some production traits, lipid peroxide and glutathione redox status of weaned piglets

Balogh, Krisztián; Hausenblasz, J.; Kovács-Weber, Mária; Erdélyi, Márta; Fodor, József; Mézes, Miklós

doi:10.1556/avet.55.2007.4.5

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…In the present study, the exposure of piglets (E2 group) to mycotoxins mixture did not influence the performance of animals (27.83 ± 1.1 vs 27.09 ± 1.3 for body weight and 1.48 ± 0.9 vs 1.40 ± 0.8 for feed intake) and biochemical parameters when compared to control. Similarly, Balogh et al [61] reported that piglets fed with approximately 0.4 mg/kg of OTA during the starter (0-28 days) and grower (29-49 days) period did not register significantly changes in the production traits and clinical signs of toxicity in the grower phase. In contrast, a significant decrease of body weight gain was observed during the starter period when the animals were more sensitive.…”

Section: Discussionmentioning

confidence: 90%

The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A

Popescu

Bulgaru

Untea

et al. 2021

Toxins

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The purpose of this study was to investigate the potential of a byproduct mixture derived from grapeseed and sea buckthorn oil industry to mitigate the harmful damage produced by ochratoxin A and aflatoxin B1 at hepatic and renal level in piglets after weaning. Forty cross-bred TOPIGS-40 hybrid piglets after weaning were assigned to three experimental groups (E1, E2, E3) and one control group (C), and fed with experimental diets for 30 days. The basal diet was served as a control and contained normal compound feed for starter piglets without mycotoxins. The experimental groups were fed as follows: E1—basal diet plus a mixture (1:1) of two byproducts (grapeseed and sea buckthorn meal); E2—the basal diet experimentally contaminated with mycotoxins (479 ppb OTA and 62ppb AFB1); and E3—basal diet containing 5% of the mixture (1:1) of grapeseed and sea buckthorn meal and contaminated with the mix of OTA and AFB1. After 4 weeks, the animals were slaughtered, and tissue samples were taken from liver and kidney in order to perform gene expression and histological analysis. The gene expression analysis showed that when weaned piglets were fed with contaminated diet, the expression of most analyzed genes was downregulated. Among the CYP450 family, CYP1A2 was the gene with the highest downregulation. According to these results, in liver, we found that mycotoxins induced histomorphological alterations in liver and kidney and had an effect on the expression level of CYP1A2, CYP2A19, CYP2E1, and CYP3A29, but we did not detect important changes in the expression level of CY4A24, MRP2 and GSTA1 genes.

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Section: Discussionmentioning

confidence: 90%

The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A

Popescu

Bulgaru

Untea

et al. 2021

Toxins

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“…Trichothecenes are the most studied group of Fusarium mycotoxins and have been implicated in many cases of mycotoxicoses in animals and humans (Placinta et al, 1999;Dönmez and Keskin, 2008). The trichothecenes are recognized as having inhibitory effects on cells, including inhibition of protein, DNA and RNA synthesis, interference with cell-membrane integrity, and induction of apoptosis (Balogh et al, 2007;Weber et al, 2010). The trichothecenes are recognized as having inhibitory effects on cells, including inhibition of protein, DNA and RNA synthesis, interference with cell-membrane integrity, and induction of apoptosis (Balogh et al, 2007;Weber et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of feeding wheat naturally contaminated with Fusarium mycotoxins on blood biochemistry and the effectiveness of dietary lignin treatment to alleviate mycotoxin adverse effects in broiler chickens

Klapáčová¹,

Faixová²,

Gresáková³

et al. 2011

Acta vet. (Beogr.)

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A study was conducted to investigate the effects of feeding wheat naturally contaminated with Fusarium mycotoxins on some biochemical parameters and the efficacy of lignin to alleviate adverse effects of fusariotoxins in broiler chickens. Eighty, 1-d-old ROSS 308 broiler chicks of both sexes were used in the experiment. All birds received the control diet for two weeks and then they were fed experimental diets for two more weeks. The 4 diets included the following: 1.) negative control diet (0.1 mg DON/kg diet; 0.005 mg ZEA/kg diet), 2.) positive control diet (0.1 mg DON/kg diet, 0.005 mg ZEA/kg diet + 0.5% lignin), 3.) mycotoxin-contaminated diet (2.95 mg DON/kg diet, 1.59 mg ZEA/kg diet) and 4.) mycotoxincontaminated diet with the addition of lignin at 0.5% of the diet (2.95 mg DON/kg diet, 1.59 mg ZEA/kg diet + 0.5% lignin). The feeding of contaminated wheat did not significantly affect parameters of mineral metabolism, including calcium, chlorides and phosphorus. Decreased levels of total protein, albumin and potassium were observed. However, dietary supplementation with lignin prevented this effect. Plasma triglycerides and free glycerol levels were not affected by dietary treatments. There was a significant increase in aspartate aminotransferase and alkaline phosphatase activities and magnesium and cholesterol levels in plasma from birds fed contaminated wheat. Inclusion of lignin in the diet reversed elevated alkaline phosphatase activity in chicks induced by mycotoxin-contaminated diet. Results indicated that consumption of grain naturally contaminated with Fusarium mycotoxins can adversely affect chickens' metabolism. As a food additive, lignin was not effective in the prevention of Fusarium mycotoxins effects in chickens

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“…Also, the rate of lipid peroxidation increased in different tissues as a result of feeding a mycotoxin-contaminated diet containing AFB 1 or T-2 toxin (Surai et al, 2002) and ochratoxin A (Balogh et al, 2007), which reduces the efficiency of the biological antioxidant defence system.…”

mentioning

confidence: 99%

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

Pál

Dublecz

Kovács-Weber

et al. 2009

Acta Veterinaria Hungarica

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Three groups of cockerels were fed with a control diet, with a diet contaminated with T-2 and HT-2 toxin (0.31 and 0.26 mg/kg) or with that containing a combination of T-2 and HT-2 toxin (0.32 and 0.25 mg/kg) and aflatoxin B 1 (AFB 1 , 0.38 mg/kg) for 21 days. Body weight gain and feed conversion ratio did not differ significantly among the groups. Malondialdehyde concentration of the liver was lower in the group fed the diet contaminated with the combination of T-2 + HT-2 toxin and aflatoxin B 1 as compared to the control group or the group fed T-2 + HT-2 toxins. Reduced glutathione (GSH) content of the liver was lower in the T-2 + HT-2 group than in the group fed a combination of T-2, HT-2 and aflatoxin. Reduced glutathione content of the heart was higher in the T-2 + HT-2 group than in the control group. Mycotoxin contamination had no effect on glutathione peroxidase (GSH-Px) activity in comparison to the control, but significantly lower GSH-Px activity was found in the heart of chickens in the T-2 + HT-2 + AFB 1 group than in the T-2 + HT-2 group. In this study, T-2 + HT-2 toxin and aflatoxin B 1 contamination of the diets did not affect the production traits adversely and did not exert additive effects on lipid peroxidation and on the glutathione redox system.

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Effects of ochratoxin a on some production traits, lipid peroxide and glutathione redox status of weaned piglets

Cited by 14 publications

References 19 publications

The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A

The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A

Effects of feeding wheat naturally contaminated with Fusarium mycotoxins on blood biochemistry and the effectiveness of dietary lignin treatment to alleviate mycotoxin adverse effects in broiler chickens

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

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