2020
DOI: 10.1016/j.jmbbm.2019.103550
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In vitro histomechanical effects of enzymatic degradation in carotid arteries during inflation tests with pulsatile loading

Abstract: In this paper, the objective is to assess the histomechanical effects of collagen proteolysis in arteries under loading conditions reproducing in vivo environment. Thirteen segments of common porcine carotid arteries (8 proximal and 5 distal) were immersed in a bath of bacterial collagenase and tested with a pulsatile tension/inflation machine. Diameter, pressure and axial load were monitored throughout the tests and used to derive the stressstretch curves and to determine the secant circumferential stiffness.… Show more

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Cited by 4 publications
(2 citation statements)
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References 34 publications
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“…Other tubular structures that can be excised and used to create a compliant segment for BLPs include intestine (Herbert et al, 1993), ureter (Narita et al, 2008), or their components such as small-intestine submucosa, for example (Roeder et al, 1999). One can also consider additional treatments that can lower E values of these vessels while retaining their integrity, mild enzymatic treatment being one example (Trabelsi et al, 2020).…”
Section: Choice Of Vessel Materials To Build Biofabricated Liebau Pumps Ex Vivomentioning
confidence: 99%
“…Other tubular structures that can be excised and used to create a compliant segment for BLPs include intestine (Herbert et al, 1993), ureter (Narita et al, 2008), or their components such as small-intestine submucosa, for example (Roeder et al, 1999). One can also consider additional treatments that can lower E values of these vessels while retaining their integrity, mild enzymatic treatment being one example (Trabelsi et al, 2020).…”
Section: Choice Of Vessel Materials To Build Biofabricated Liebau Pumps Ex Vivomentioning
confidence: 99%
“…Fresh porcine common carotid arteries were excised from 6-monthold Large White pigs (n ¼ 30) weighing approximately 80 kg at the time of slaughter. Excised carotid arteries were taken from the proximal end of the vessel (Trabelsi et al, 2019) and then frozen to À 80 � C at a controlled rate of À 1 � C/min in a cryoprotectant media to maintain mechanical and structural properties during storage (Müller-Schweinitzer, 2009). Prior to testing, vessels were thawed in a water bath at 37 � C to minimise tissue damage (Pegg et al, 1997), washed in PBS to remove any residual cryoprotectant and cut to approximately 30 mm in length for testing.…”
Section: Tissue Preparationmentioning
confidence: 99%