Building Valveless Impedance Pumps From Biological Components: Progress and Challenges

Abstract

Valveless pumping based on Liebau mechanism entails asymmetrical positioning of the compression site relative to the attachment sites of the pump’s elastic segment to the rest of the circuit. Liebau pumping is believed to play a key role during heart development and be involved in several other physiological processes. Until now studies of Liebau pump have been limited to numerical analyses, in silico modeling, experiments using non-biological elements, and a few indirect in vivo measurements. This review aims to stimulate experimental efforts to build Liebau pumps using biologically compatible materials in order to encourage further exploration of the fundamental mechanisms behind valveless pumping and its role in organ physiology. The covered topics include the biological occurrence of Liebau pumps, the main differences between them and the peristaltic flow, and the potential uses and body sites that can benefit from implantable valveless pumps based on Liebau principle. We then provide an overview of currently available tools to build such pumps and touch upon limitations imposed by the use of biological components. We also talk about the many variables that can impact Liebau pump performance, including the concept of resonant frequencies, the shape of the flowrate-frequency relationship, the flow velocity profiles, and the Womersley numbers. Lastly, the choices of materials to build valveless impedance pumps and possible modifications to increase their flow output are briefly discussed.

Dielectric elastomer actuator-based valveless pump as Fontan failure assist device: introduction and preliminary study

“…Another promising system within the realm of biomedical applications, boasting unique capabilities, is the impedance pump [ 18 ]. It offers a simple method of generating or amplifying flow without the need for valves or impellers [ 19 , 20 ].…”

Bioinspired Soft Bendable Peristaltic Pump Exploiting Ballooning for High Volume Throughput

“…Conversely, soft pumps reproduce the peristaltic motion observed in biological systems [4] by understanding and replicating motion primitives observed in nature [5], achieving high compliance and good flexibility. Soft peristaltic pumps generate pulsatile flow thanks to a travelling peristaltic contraction wave, unlikely Liebau pumps that exploit a periodic but spatially static contraction [6]. The bending capability of such devices makes them suitable for performing actuation in narrow and tight spaces with obstacles, such as medical applications [7].…”

Numerical Modelling of a Valveless Impedance Pump with Various Pinch Locations

“…Many researchers have carried out analytical [4] or computational studies [5] in a bid to better comprehend the mechanisms at work in the Liebau problem of valveless pumping in open [6] or closed-loop [7] systems. It is believed that Liebau pumping plays a crucial role in heart development and several other physiological processes [8]. Numerous distinctive features of the net flow produce by a Liebau effect pump are easily describe by wave dynamics [9,10].…”