In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

Zerbinati, Nicola; Sommatis, Sabrina; Maccario, Cristina; Capillo, Maria Chiara; Francesco, S. Di; Rauso, Raffaele; Protasoni, Marina; D’Este, Edoardo; Gasperina, Daniela Dalla; Mocchi, Roberto

doi:10.1155/2021/5598110

Cited by 8 publications

(8 citation statements)

References 24 publications

(24 reference statements)

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“…Formulas enriched with HA participate in reducing the inflammatory responses by decreasing the inflammatory marker IL-8 and the keratinocytes' vascular growth factors. This biological activity was confirmed after in vitro testing using a human follicle dermal papilla cell line (Zerbinati et al, 2021a).…”

Section: Haircare Productsmentioning

confidence: 64%

A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid

Al-Halaseh¹,

Tarawneh²,

Al-Jawabri³

et al. 2022

j app pharm sci

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Hyaluronic acid (HA) is an endogenous substance detected and isolated from various tissues and biological fluids. Owing to its physicochemical properties, HA contributes to many biological processes at intra-and extracellular levels, such as skin hydration, joints lubrication, and wound healing, besides its anti-inflammatory and antioxidant effects. The current review highlights the employment of exogenous HA in many aesthetic and dermatological aspects. Also, it aims to clarify the skin rejuvenating activity by compensating for the biological loss of HA with advanced age. Other positive impacts of HA on hair, nail, and overall health status were also revised. Cosmetics and cosmeceuticals that contain HA, among other active ingredients, are commercially available in different dosage forms such as gels, creams, intradermal injections, and fillers. Aesthetic enhancement is achieved via soft tissue augmentation, skin hydration level increasing, grooves refilling, and collagen and elastin biosynthesis stimulation. HA contributes to various therapeutic approaches such as gingivitis, stomatitis, ulceration, and osteoarthritis. Additionally, it has beneficial uses in dentistry due to its antioxidant and anti-inflammatory properties. The recent implication of HA following the claims that it has a rejuvenating power for the skin and many therapeutic benefits has to be thoroughly investigated and delivered by a trained expert to avoid undesirable effects.

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Section: Haircare Productsmentioning

confidence: 64%

A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid

Al-Halaseh¹,

Tarawneh²,

Al-Jawabri³

et al. 2022

j app pharm sci

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“…155 Zerbinati et al reported that a noncross-linked hyaluronic acid filler containing several amino acids resulted in increased secretion of vascular endothelial growth factor from DPCs within the culture system. 158 It was also found that supplementing the system with 0.5 mg/mL hyaluronic acid promoted the organization and development of HF organoids. 157 From the above we can see that the potential of hyaluronic acid in HF cell culture is worth exploring.…”

Section: Acs Biomaterialsmentioning

confidence: 96%

“…Nonetheless, it has been reported that hyaluronic acid with a molecular weight of less than 500 kDa is detrimental to the proliferation of DPCs When glycosaminoglycan hydrogel was used as a matrix to culture HF cells, WNT/β-catenin signaling was successfully activated and specific induction of TGFβ2 was observed . Zerbinati et al reported that a non-cross-linked hyaluronic acid filler containing several amino acids resulted in increased secretion of vascular endothelial growth factor from DPCs within the culture system . It was also found that supplementing the system with 0.5 mg/mL hyaluronic acid promoted the organization and development of HF organoids .…”

Section: Homeostatic Construction Of Hf Organoids Via a Biomaterials ...mentioning

confidence: 99%

Innovative Approaches and Advances for Hair Follicle Regeneration

Zheng

2023

ACS Biomater. Sci. Eng.

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Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation of mechanisms in tissue engineering, the proliferation of HFs in vitro has achieved more promising trust for the treatments of alopecia and other skin impairments. Theoretically, HF organoids have great potential to develop into native HFs and attachments such as sweat glands after transplantation. However, since the rich extracellular matrix (ECM) deficiency, the induction characteristics of skin-derived cells gradually fade away along with their trichogenic capacity after continuous cell passaging in vitro. Therefore, ECM-mimicking support is an essential prelude before HF transplantation is implemented. This review summarizes the status of providing various epidermal and dermal cells with a threedimensional (3D) scaffold to support the cell homeostasis and better mimic in vivo environments for the sake of HF regeneration. HF-relevant cells including dermal papilla cells (DPCs), hair follicle stem cells (HFSCs), and mesenchymal stem cells (MSCs) are able to be induced to form HF organoids in the vitro culture system. The niche microenvironment simulated by different forms of biomaterial scaffold can offer the cells a network of ordered growth environment to alleviate inductivity loss and promote the expression of functional proteins. The scaffolds often play the role of ECM substrates and bring about epithelial−mesenchymal interaction (EMI) through coculture to ensure the functional preservation of HF cells during in vitro passage. Functional HF organoids can be formed either before or after transplantation into the dermis layer. Here, we review and emphasize the importance of 3D culture in HF regeneration in vitro. Finally, the latest progress in treatment trials and critical analysis of the properties and benefits of different emerging biomaterials for HF regeneration along with the main challenges and prospects of HF regenerative approaches are discussed.

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“…The results showed that HA fillers protected DPCs from oxidative stress, promoted the release of the VEGF, and demonstrated the in vitro hair growth‐promoting effect of uncrosslinked HA. [ 70 ] We have also reviewed methods using macromolecular microneedle (MN) and nanoparticle (NP) platforms for the treatment of hair loss or hair regeneration using various drugs or exosomes.…”

Section: Recent Studies On Hair Regeneration Using Macromoleculesmentioning

confidence: 99%

Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment

Kang

Park

et al. 2023

Macromolecular Bioscience

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Macromolecules are large, complex molecules composed of smaller subunits known as monomers. The four primary categories of macromolecules found in living organisms are carbohydrates, lipids, proteins, and nucleic acids; they also encompass a broad range of natural and synthetic polymers. Recent studies have shown that biologically active macromolecules can help regenerate hair, providing a potential solution for current hair regeneration therapies. This review examines the latest developments in the use of macromolecules for the treatment of hair loss. The fundamental principles of hair follicle (HF) morphogenesis, hair shaft (HS) development, hair cycle regulation, and alopecia have been introduced. Microneedle (MN) and nanoparticle (NP) delivery systems are innovative treatments for hair loss. Additionally, the application of macromolecule‐based tissue‐engineered scaffolds for the in vitro and in vivo neogenesis of HFs is discussed. Furthermore, a new research direction is explored wherein artificial skin platforms are adopted as a promising screening method for hair loss treatment drugs. Through these multifaceted approaches, promising aspects of macromolecules for future hair loss treatments are identified.

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In Vitro Hair Growth Promoting Effect of a Noncrosslinked Hyaluronic Acid in Human Dermal Papilla Cells

Cited by 8 publications

References 24 publications

A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid

A review of the cosmetic use and potentially therapeutic importance of hyaluronic acid

Innovative Approaches and Advances for Hair Follicle Regeneration

Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment

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