In Vitro/ Ex Vivo Antiplasmodial Activity and Phytochemical Screening of Crude Extracts Entandrophragma angolense (Welw.) C. DC., Griffonia simplicifolia (Vahl ex DC.) Baill .et Uapaca guineensis Müll. Arg. three Plants of Ivorian Pharmacopeia in the Treatment of Malaria

Offoumou, M’Bai Rostand; Kipre, G. R.; Kigbafori, D.S.; Camara, Djeneb; Djaman, Allico Joseph; Zirihi, Guédé Noël

doi:10.20546/ijcmas.2018.703.245

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study assessed the antioxidant activity of the aqueous Griffonia simplicifolia leaf extract (at a concentration of 20 µg/mL) via the protection of astrocytes and neurons [52]. In a recent study by Offoumou et al the aqueous extracts of medicinal plants, especially Griffonia simplicifolia, exhibited antimalarial activity against Plasmodium falciparum [53]. Giurleo et al [10] have evaluated flavone C-Glycosides and total antioxidant capacities in the leaves of eight wild Griffonia simplicifolia populations.…”

Section: Beneficial Activities Of Griffonia Simplicifolia Based On In...mentioning

confidence: 99%

Beneficial Properties and Sustainable Use of a Traditional Medicinal Plant: Griffonia simplicifolia

Nazhand,

Durazzo,

Lucarini

et al. 2024

Challenges

View full text Add to dashboard Cite

Since ancient times, medicinal plants have been a universal source of biologically active substances with high potential for the treatment of various diseases and disorders. For centuries, traditional communities have often relied on medicinal plants to treat health problems. Therefore, accurate information is required and knowledge about traditional medicinal plants requires evaluation, and great attention should be given to the possible integration of these plants as therapeutic agents or as complements to conventional pharmacological therapies in the healthcare system. Recently, Griffonia simplicifolia (DC.) Baill., initially used as a holistic remedy, has attracted attention from many researchers and consumers because of its multiple health-promoting effects. This growing interest prompted us to give an updated review of the botanical, geographical, historical, and therapeutic potentials of Griffonia simplicifolia (DC.) Baill. in terms of its in vitro and in vivo health effects, nutritional uses, and possible applications in line with biodiversity and sustainability concepts. This paper also presents a quantitative research analysis of the published studies related to this plant that are available in the literature. To retrieve the publications related to this plant, a bibliographic search was carried out using the Scopus database. The bibliometric data were extracted and processed using VOSviewer software (v.1.6.16, 2020). Technological possible applications in terms of patents request presented was also performed. A total of 1386 publications, from the year 1970 to the year 2021, were obtained by the literature search, and these had been collectively cited 38,805 times. The large amount of literature data available documents the interest in this plant’s use as a tool for integrating traditional holistic healing approach, e.g., using plants, herbs, and holistic remedies, into the healthcare system as supporting tools and/or therapeutic agents, which is a current worldwide challenge.

show abstract

Section: Beneficial Activities Of Griffonia Simplicifolia Based On In...mentioning

confidence: 99%

Beneficial Properties and Sustainable Use of a Traditional Medicinal Plant: Griffonia simplicifolia

Nazhand,

Durazzo,

Lucarini

et al. 2024

Challenges

View full text Add to dashboard Cite

show abstract

“…Indeed, 5-hydroxytryptophan (5-HTP) has been identified as the most important chemical element of this plant species. Also secondary metabolites such as tannins, alkaloids, flavonoids, saponins and coumarins have been identified in the methanoic, aqueous and hydro-methanoic extract of its seeds [17] [18] [19]. Other researchers have studied its antioxidant activity [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of Methanolic and Aqueous Extracts of <i>Griffonia simplicifolia</i> (Fabaceae) on the Inhibition of Falciformation of Human Hb SS Erythrocytes

Akakpo-Akue¹,

Ahon²,

Kple³

et al. 2023

OJAppS

View full text Add to dashboard Cite

Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transportation of red blood cells (RBCs) in blood vessels, leading to various clinical complications. Sickle cell disease is a widespread genetic disease in Black Africa. The objective of this study was to evaluate the sickling inhibition activity of Griffonia simplicifolia. Quantitative and qualitative tests were used to determine the major groups of secondary metabolites present in the Griffonia simplicifolia leaves extracts and the modified Emmel test was used to perform the study of sickling inhibition activity. The OECD 423 toxicity study showed that at a single dose of 2000 mg/kg bw, Griffonia simplicifolia leaves extracts are not toxic. All tested substances inhibit erythrocyte falciformation in a dose-dependent manner. The percentages of inhibition were 50.35%, 73% and 94.23% for aqueous extract, hydromethanolic extract and phenylalanine respectively at the concentration of 15 mg/mL. The methanolic extract (70%) had higher activity compared to the aqueous extract. These results suggest that the Griffonia simplicifolia extracts have some potential to be used as alternative antisickling therapy in SCD management.

show abstract

Griffonia simplicifolia (DC.) Baill. attenuates gentamicin and cisplatin-induced nephrotoxicty in rats

et al. 2019

View full text Add to dashboard Cite

In Vitro/ Ex Vivo Antiplasmodial Activity and Phytochemical Screening of Crude Extracts Entandrophragma angolense (Welw.) C. DC., Griffonia simplicifolia (Vahl ex DC.) Baill .et Uapaca guineensis Müll. Arg. three Plants of Ivorian Pharmacopeia in the Treatment of Malaria

Cited by 4 publications

References 0 publications

Beneficial Properties and Sustainable Use of a Traditional Medicinal Plant: Griffonia simplicifolia

Beneficial Properties and Sustainable Use of a Traditional Medicinal Plant: Griffonia simplicifolia

Effects of Methanolic and Aqueous Extracts of <i>Griffonia simplicifolia</i> (Fabaceae) on the Inhibition of Falciformation of Human Hb SS Erythrocytes

Griffonia simplicifolia (DC.) Baill. attenuates gentamicin and cisplatin-induced nephrotoxicty in rats

Contact Info

Product

Resources

About

In Vitro/ Ex Vivo Antiplasmodial Activity and Phytochemical Screening of Crude Extracts Entandrophragma angolense (Welw.) C. DC., Griffonia simplicifolia (Vahl ex DC.) Baill .et Uapaca guineensis Müll. Arg. three Plants of Ivorian Pharmacopeia in the Treatment of Malaria

Cited by 4 publications

References 0 publications

Beneficial Properties and Sustainable Use of a Traditional Medicinal Plant: Griffonia simplicifolia

Beneficial Properties and Sustainable Use of a Traditional Medicinal Plant: Griffonia simplicifolia

Effects of Methanolic and Aqueous Extracts of &lt;i&gt;Griffonia simplicifolia&lt;/i&gt; (Fabaceae) on the Inhibition of Falciformation of Human Hb SS Erythrocytes

Griffonia simplicifolia (DC.) Baill. attenuates gentamicin and cisplatin-induced nephrotoxicty in rats

Contact Info

Product

Resources

About

Effects of Methanolic and Aqueous Extracts of <i>Griffonia simplicifolia</i> (Fabaceae) on the Inhibition of Falciformation of Human Hb SS Erythrocytes