In vitro evaluation of wound healing and antimicrobial potential of ozone therapy

Borges, Gabriel Álvares; Elias, Silvia Taveira; Silva, Sandra Márcia Mazutti da; Magalhães, Pérola Oliveira; Macedo, Sérgio Bruzadelli; Ribeiro, Ana Paula Dias; Guerra, Eliete Neves Silva

doi:10.1016/j.jcms.2017.01.005

Cited by 69 publications

(45 citation statements)

References 25 publications

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“…At the moment, ozonated vegetable oils are used externally for the management and prevention of various skin diseases [12]. The pathological conditions that benefit from this type of treatment are infectious skin diseases, abscesses and athlete's foot [50][51][52][53], allergic diseases, such as atopic dermatitis, eczema, urticarial and prurigo [54,55], erythema scaly diseases, such as psoriasis and palmoplantar pustulosis [56,57], wound healing, and ulcer recovery [58].…”

Section: Topical Applications Of Ozonated Oilsmentioning

confidence: 99%

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Ugazio

Tullio²,

Binello

et al. 2020

Molecules

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The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest and clinical applications. The treatment of vegetable oils with ozone leads to the creation of a reservoir of ozone that slowly releases into the skin thanks to the fact that ozone can be held as ozonides of unsaturated fatty acids. Interest in the use of ozonated oils has meant that several ozonated-vegetable-oil-containing products have been commercialized as cosmetic and pharmaceutical agents, and in innovative textile products with antibacterial activity. New approaches to the delivery of ozonated oils have very recently appeared in an attempt to improve their characteristics and reduce drawbacks, such as an unpleasant odor, high viscosity and undesired effects on skin, including irritation and rashes. The present review focuses on the current status of delivery agents that use ozonated oils as antimicrobial agents in topical (dermal, skin, and soft tissues) treatments. Challenges and future opportunities for these delivery systems will also be discussed.

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Section: Topical Applications Of Ozonated Oilsmentioning

confidence: 99%

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Ugazio

Tullio²,

Binello

et al. 2020

Molecules

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“…Research in vitro evaluation of wound healing and antimicrobial potential of ozone therapy performed by (Borges et al, 2017), although ozone therapy is widely applied when wound repair and antimicrobial effects, little is known about the cellular mechanisms of this process. The effects of ozone on cell migration are evaluated through initial wound healing and trans well migration tests.…”

Section: Discussionmentioning

confidence: 99%

Home Care by Ozone Bagging towards Diabetic Foot Ulcers Healing

Mediarti

Rehana

Arifin

2018

Proceedings of the 9th International Nursing Conference

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The global prevalence of DM patients in 2014 is 8.3% of the total population in the world. Increased prevalence of DM followed by increased incidence of diabetic foot ulcers. The American Diabetes Association mentioned that in 2010 there were approximately 73,000 cases of non-traumatic limb amputations with a diagnosis of DM. The purpose of this study was to determine the effect of home care with modern wound care: ozone bagging towards diabetic foot ulcers healing in Palembang. This research used quantitative and qualitative approach with mixed methodology design. The samples obtained 42 people by purposive sampling technique. Quantitative analysis used dependent samples paired t-test and qualitative used non-statistical analysis through logical inference based on actual considerations and conditions. The average before treatment were 36.21 with SD = 4.076 and after treatment were 37.17 with SD = 4.316. Home care with modern wound care: ozone bagging gave effect on wound healing of patients with diabetic foot ulcers (p = 0.026). All participants expressed feelings of great satisfaction. Therefore, it is necessary to develop further research, by developing design and intervention in several groups, so it can assess the effectiveness of ozone bagging for healing diabetic foot ulcers through home care.

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“…[9] Ozon gazının antimikrobiyal etkinliği, enfekte yaralarda da yararlı olmasını sağlar. [20] Diyabetik ayak ülserinde, 61 olgu üzerinde yapılan çalışmada, etkinliği şöyle açıklanmaktadır: talamus ve kortekse giden stimülan sinyalleri bloke eden endorfin salını-mı, C-nosiseptörlerin oksidatif dejenerasyonuna bağlı daha az uyarılması, desandan antinosiseptif sistemin aktivasyonu, lokalize oksijenizasyon ve analjezi sonucunda laktat oksidasyonu, asidozun nötralizasyonu, kalsiyum geri alınımı, adenozin-trifosfat (ATP) sentezinde artış ve ödem reabsorpsiyonu ile kasta gevşeme ve vazodilatasyon sağlanması. [1] Tetik nokta enjeksiyonlarında, cilt altına 5 µg/mL ve 2-3 mL, lezyon içine ise 10 µg/mL ve 2-3 mL ozon gazı enjekte edilebilir.…”

Section: Kronik (İyileşmeyen) Yaralarda Ozon Tedavisiunclassified

Ozon tedavisi

Kesikburun¹,

Yaşar²

2017

TOTBID

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In vitro evaluation of wound healing and antimicrobial potential of ozone therapy

Cited by 69 publications

References 25 publications

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Home Care by Ozone Bagging towards Diabetic Foot Ulcers Healing

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