In Vitro Evaluation of the Efficacy of a Silver-Coated Catheter

Gabriel, Manal M.; Mayo, M S; May, Lauren L.; Simmons, Robert B.; Ahearn, Donald G.

doi:10.1007/s002849900064

Cited by 68 publications

(36 citation statements)

References 11 publications

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“…Silver has been used in catheters in attempts to prevent biofilm formation (60,118,122). The use of an Environmental Protection Agency (EPA) (http://www.epa.gov/safewater/mcl.html)-approved level (100 g/liter) of silver nitrate as a disinfectant in drinking water did not significantly prevent (P Յ 0.05) bacterial biofilm formation in modified Robbins devices with polyvinyl chloride and stainless steel surfaces in comparison to the control treatment (317).…”

Section: Resistance To Metalsmentioning

confidence: 99%

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia can occur in a range of organs and tissues; the organism is commonly found in respiratory tract infections. This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection. S. maltophilia can be recovered from polymicrobial infections, most notably from the respiratory tract of cystic fibrosis patients, as a cocolonizer with Pseudomonas aeruginosa . Recent evidence of cell-cell communication between these pathogens has implications for the development of novel pharmacological therapies. Animal models of S. maltophilia infection have provided useful information about the type of host immune response induced by this opportunistic pathogen. Current and emerging treatments for patients infected with S. maltophilia are discussed.

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Section: Resistance To Metalsmentioning

confidence: 99%

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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“…Silver has been reported to delay or prevent the formation of biofilms in medical catheters (8,13,15,33), prosthetic heart valves (3,17), vascular grafts, and fracture fixation devices (6,9). Silver has also been used in water filters (31), cooling towers (22), and DSs (23,26,29).…”

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confidence: 99%

Silver as a Residual Disinfectant To Prevent Biofilm Formation in Water Distribution Systems

Silvestry-Rodriguez

Bright

Slack

et al. 2008

Appl Environ Microbiol

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“…The mechanism of antibacterial activity proposed is associated with an initial inhibition of primary adherence due to the hydrogel hydrophilicity, followed by secondary biocidal activity of the silver coating [32,34].…”

Section: Discussionmentioning

confidence: 99%

The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

Cooper

Pollini

Paladini

2016

Materials Science and Engineering: C

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Catheter-associated urinary tract infection (CAUTI) represents one of the most common causes of morbidity and mortality. The resistance demonstrated by many microorganisms to conventional antibiotic therapies and the in-creasing health-care costs have recently encouraged the definition of alternative preventive strategies, which can have a positive effect in the management of infections.Antimicrobial urinary catheters have been developed through the photo-chemical deposition of silver coatings on the external and luminal surfaces. The substrates are exposed to ultraviolet radiation after impregnation into a silver-based solution, thus inducing the in situ synthesis of silver particles. The effect of the surface treatment on the material was investigated through scanning electron microscopy (SEM) and silver ion release measurements. The ability of microorganisms commonly associated with urinary tract infections was investigated in terms of bacterial viability, proliferation and biofilm development, using Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis as target organisms. The silver coatings demonstrated good distribution of silver particles to the substrate, and proved an effective antibacterial capability in simulated biological conditions.The low values of silver ion release demonstrated the optimum adhesion of the coating. The results indicated a good potential of silver-based antimicrobial materials for prevention of catheterassociated urinary tract infection.

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In Vitro Evaluation of the Efficacy of a Silver-Coated Catheter

Cited by 68 publications

References 11 publications

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

Silver as a Residual Disinfectant To Prevent Biofilm Formation in Water Distribution Systems

The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

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