The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

Cooper, Ian; Pollini, Mauro; Paladini, Federica

doi:10.1016/j.msec.2016.07.004

Cited by 19 publications

(12 citation statements)

References 44 publications

(55 reference statements)

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“…The mechanism of action of silver is already well characterized, and its application in UC was already approved by the Food and Drug Administration (FDA). [61,62] Since 1980, [63] numerous studies have evaluated the in vitro efficacy of 1) silver (ions/nanoparticles), [64][65][66][67] 2) silver-polymer nanocomposites, [68][69][70][71][72][73][74] and 3) silver conjugated with antibiotic agents. [75] Silver and its formulations were studied in different polymeric surfaces, including silicone, polyurethane, and latex, and tested against a broad spectrum of Gram-positive and Gramnegative bacteria, in both in vitro and in vivo studies.…”

Section: Coatingsmentioning

confidence: 99%

“…[75] Silver and its formulations were studied in different polymeric surfaces, including silicone, polyurethane, and latex, and tested against a broad spectrum of Gram-positive and Gramnegative bacteria, in both in vitro and in vivo studies. [67,68,74,[76][77][78][79] For all these reasons, silver is a promising coating for ureteral stent devices, and it has been widely investigated for coating application in the urinary tract context. Nonetheless, contradicting studies already described the ineffectiveness of this strategy, reporting no significant advantages against UTIs.…”

Section: Coatingsmentioning

confidence: 99%

See 1 more Smart Citation

Future Directions for Ureteral Stent Technology: From Bench to the Market

Domingues

Pacheco

Cruz

et al. 2021

Advanced Therapeutics

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Ureteral stents are broadly used for the treatment of a wide range of pathologies, with different complexities and characteristics. Despite being efficient, the morbidity associated with stents, such as bacterial infection and pain, limits their therapeutic action and often represents an increase in healthcare costs. As no single solution fits all problems, there is still a need to improve these medical devices. Throughout this review, the most recent innovations are outlined and suggestions regarding future directions for ureteral stent technology are formulated with respect to materials, coatings, and designs of these devices. As highlighted here, during the process of passing these innovations to the growing market of ureteral stents, one of the biggest challenges is to increase the predictive value of the in vitro assays and, consequently, reduce the number of in vivo tests needed. Thus, recommendations concerning in vitro standard testing of these devices are provided, with focus on medium, flow conditions, and microbiological parameters. Additionally, the reader is also presented with insights about a crucial but rarely discussed topic, the bureaucratic part of the bench to market process, particularly the product certification legislation in Europe.

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Section: Coatingsmentioning

confidence: 99%

Section: Coatingsmentioning

confidence: 99%

Future Directions for Ureteral Stent Technology: From Bench to the Market

Domingues

Pacheco

Cruz

et al. 2021

Advanced Therapeutics

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show abstract

“…Along with the well-known antimicrobial properties [ 117 , 118 , 119 , 120 ], some studies have also demonstrated a role of silver nanoparticles in wound healing, which can further improve the biological properties of fibroin through the development of fibroblasts into myofibroblasts, thus promoting wound contraction and healing rate, and stimulating keratinocyte proliferation [ 121 , 122 , 123 , 124 ].…”

Section: Antibacterial Silk Fibroinmentioning

confidence: 99%

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Pollini

Paladini

2020

Materials

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Nature is an incredible source of inspiration for scientific research due to the multiple examples of sophisticated structures and architectures which have evolved for billions of years in different environments. Numerous biomaterials have evolved toward high level functions and performances, which can be exploited for designing novel biomedical devices. Naturally derived biopolymers, in particular, offer a wide range of chances to design appropriate substrates for tissue regeneration and wound healing applications. Wound management still represents a challenging field which requires continuous efforts in scientific research for definition of novel approaches to facilitate and promote wound healing and tissue regeneration, particularly where the conventional therapies fail. Moreover, big concerns associated to the risk of wound infections and antibiotic resistance have stimulated the scientific research toward the definition of products with simultaneous regenerative and antimicrobial properties. Among the bioinspired materials for wound healing, this review focuses attention on a protein derived from the silkworm cocoon, namely silk fibroin, which is characterized by incredible biological features and wound healing capability. As demonstrated by the increasing number of publications, today fibroin has received great attention for providing valuable options for fabrication of biomedical devices and products for tissue engineering. In combination with antimicrobial agents, particularly with silver nanoparticles, fibroin also allows the development of products with improved wound healing and antibacterial properties. This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.

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“…The best approach to fight CAUTI relies on preventing the establishment of biofilms and it can be accomplished by modification of urinary catheter surfaces so they can resist microbial colonization (Yu et al, 2017). A number of coating strategies have been reported with this aim, but most of them comprise mechanisms to prevent the colonization of bacteria (Lim et al, 2015; Cooper et al, 2016; Singha et al, 2017). As stated by the European Center for Disease Prevention and Control, in an annual epidemiological report from 2014, the most commonly isolated microorganisms from catheter infections were Escherichia coli (28%) followed by Candida species (18%).…”

Section: Introductionmentioning

confidence: 99%

Design of an Antifungal Surface Embedding Liposomal Amphotericin B Through a Mussel Adhesive-Inspired Coating Strategy

et al. 2019

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Microbial colonization of urinary catheters remains a serious problem for medicine as it often leads to biofilm formation and infection. Among the approaches reported to deal with this problem, surfaces functionalization to render them with antimicrobial characteristics, comprises the most promising one. Most of these strategies, however, are designed to target bacterial biofilms, while fungal biofilms are much less taken into account. In real-life settings, fungi will be inevitably found in consortium with bacteria, especially in the field of biomaterials. The development of antifungal coating strategies to be combined with antibacterial approaches will be pivotal for the fight of biomaterial-associated infections. The main goal of the present study was, therefore, to engineer an effective strategy for the immobilization of liposomal amphotericin B (LAmB) on polydimethylsiloxane (PDMS) surfaces to prevent Candida albicans colonization. Immobilization was performed using a two-step mussel-inspired coating strategy, in which PDMS is first immersed in dopamine solution. Its polymerization results in the deposition of a thin adherent film, called polydopamine (pDA), which allowed the incorporation of LAmB, afterwards. Different concentrations of LAmB were screened in order to obtain a contact-killing surface with no release of LAmB. Surface characterization confirmed the polymerization of dopamine and further functionalization with LAmB yielded surfaces with less roughness and more hydrophilic features. The proposed coating strategy rendered the surfaces of PDMS with the ability to prevent the attachment of C. albicans and kill the adherent cells, without toxicity toward mammalian cells. Overall results showed that LAmB immobilization on a surface retained its antifungal activity and reduced toxicity, holding therefore a great potential to be applied for the design of urinary catheters. Since the sessile communities commonly found associated to these devices exhibit a polymicrobial nature, the next challenge will be to co-immobilize LAmB with antibacterial agents to prevent the establishment of catheter-associated urinary tract infections (CAUTI).

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The potential of photo-deposited silver coatings on Foley catheters to prevent urinary tract infections

Cited by 19 publications

References 44 publications

Future Directions for Ureteral Stent Technology: From Bench to the Market

Future Directions for Ureteral Stent Technology: From Bench to the Market

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Design of an Antifungal Surface Embedding Liposomal Amphotericin B Through a Mussel Adhesive-Inspired Coating Strategy

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