In vitro evaluation of experimental light activated gels for tooth bleaching

Kurzmann, Christoph; Verheyen, Jeroen; Coto, Michael; Kumar, R. Vasant; Divitini, Giorgio; Shokoohi-Tabrizi, Hassan Ali; Verheyen, Peter; Moor, R. J. G. De; Moritz, Andreas; Agis, Hermann

doi:10.1039/c8pp00223a

Cited by 22 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They observed that diluted gel formulations tested against L-929 cells, 3T3 cells, and gingival fibroblasts did not reveal any noticeable reduction in cell viability. The authors suggested additional experiments aiming to assess the TiO 2 gel toxicity [92]. Sodagar et al solved the problem of caries next to brackets in orthodontic treatment.…”

Section: Other Applications Of Tio 2 Nanoparticles In Medicinementioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

View full text Add to dashboard Cite

Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.

show abstract

Section: Other Applications Of Tio 2 Nanoparticles In Medicinementioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Thus, a low-concentration bleaching agent group has been introduced, where the effect of peroxide is catalyzed and strengthened by an agent such as TiO 2 , which produces free radicals such as vital oxygen and hydroxyl when exposed to light. 31 Furthermore, Kurzman et al 32 reported that experimental bleaching gels containing TiO 2 had lower cytotoxicity than gels containing only HP. The use of TiO 2 as a semiconductor and photocatalytic agent requires the use of UV light (<380 nm).…”

Section: Discussionmentioning

confidence: 99%

Three‐month evaluation of a low concentration (6% hydrogen peroxide) experimental bleaching gel containing Tio₂ and chitosan: An in vitro study

Özçetin

Sürmelioğlu

2020

Color Research & Application

View full text Add to dashboard Cite

The study aimed to compare the effectiveness of an experimental gel that contained 6% hydrogen peroxide, titanium dioxide (TiO 2), and chitosan nanoparticles with that of the two bleaching agents that are routinely used and evaluate their effectiveness in a 3-month period. Seventy-two extracted premolar teeth were divided into three groups for the bleaching procedure. TiO 2 and chitosan were added to increase the whitening effect of the low-concentration experimental gel. In group 1, the experimental gel was applied and activated with a D-Light Duo LED device. In group 2, Opalescence Boost PF was applied chemically. In group 3, Philips Zoom was applied and activated with Zoom Advanced Power. The color of the teeth was measured with a Vita Easyshade Advance 4.0 spectrophotometer before the bleaching and 24 hours, 7 days, 14 days, 30 days, and 3 months after final bleaching. The CIEDE2000 color dif

show abstract

“…Medical/biological use [96] TiO2 (anatase, 25 nm) TiO2/Ag NPs commercial distribution of TiO2 anatase powder was mixed with silver nitrate, reduced and heated at 300 °C toxicity reduction of teeth whitening gels [97] TiO2 (anatase, ≤ 15μm) Eggshell-TiO2 composite (irregular, spherical shape particles, ≤ 13 nm)…”

Section: Methods Of Synthesismentioning

confidence: 99%

“…They observed that diluted gel formulations tested against L-929 cells, 3T3 cells, and gingival fibroblasts did not reveal any noticeable reduction in cells viability. The authors suggested additional experiments aiming to assess the TiO2 gels toxicity [96]. Sodagar et al solved the problem of caries next to brackets in orthodontic treatment.…”

Section: Methods Of Synthesismentioning

confidence: 99%

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

Mlynarczyk

et al. 2020

Preprint

101

View full text Add to dashboard Cite

Metallic nanoparticles (NPs), among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in the novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites with other molecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 NPs, leading to hybrid materials. These nanostructures can reveal increased light absorption allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer therapy, many approaches utilizing titanium dioxide were tested. The most significant studies are discussed in this review.

show abstract

In vitro evaluation of experimental light activated gels for tooth bleaching

Abstract: Gels containing TiO2/Ag or TiO2 particles are less cytotoxic than hydrogen peroxide-containing gels. TiO2/Ag gel exhibited a stronger reduction of metabolic activity and viability than TiO2 gel.

Cited by 22 publications

References 38 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Three‐month evaluation of a low concentration (6% hydrogen peroxide) experimental bleaching gel containing Tio₂ and chitosan: An in vitro study

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Contact Info

Product

Resources

About

In vitro evaluation of experimental light activated gels for tooth bleaching

Abstract: Gels containing TiO2/Ag or TiO2 particles are less cytotoxic than hydrogen peroxide-containing gels. TiO2/Ag gel exhibited a stronger reduction of metabolic activity and viability than TiO2 gel.

Cited by 22 publications

References 38 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Three‐month evaluation of a low concentration (6% hydrogen peroxide) experimental bleaching gel containing Tio2 and chitosan: An in vitro study

Titanium Dioxide Nanoparticles &ndash; Prospects and Applications in Medicine

Contact Info

Product

Resources

About

Three‐month evaluation of a low concentration (6% hydrogen peroxide) experimental bleaching gel containing Tio₂ and chitosan: An in vitro study

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine