2010
DOI: 10.1590/s1516-84842010005000087
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In vitro effect of the herbicide glyphosate on human blood platelet aggregation and coagulation

Abstract: Glyphosate [N-(phosphonomethyl)-glycine] is a broad-spectrum, non-selective, postemergence herbicide that is extensively used in agriculture. Published data referring to the effects of this product on human health are contradictory. We showed previously that long-term treatment of rats with low doses of Glyphosate-Biocarb® may induce hepatic histological changes and bleeding without decreasing platelet counts. The aim of the current study was to investigate, in vitro, the effect of glyphosate on human blood pl… Show more

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Cited by 9 publications
(6 citation statements)
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“…However, recent studies have suggested that long-term exposure to the chemical can cause toxicity in pregnant rats, with bone development deficiency in the fetus (Dallegrave, 2003), changes in cellular metabolism (Marc et al , 2004a; 2004b), cutaneous lesions (Amerio et al , 2004), and increased rates of non-Hodgkin's lymphoma (De Ross et al , 2003). Furthermore, studies using low doses of glyphosate-Biocarb ® have shown that the product can cause significant hepatic changes, as well as nasal bleeding without interfering in platelet aggregation (Benedetti et al , 2004; Neiva et al , 2010). …”
Section: Introductionmentioning
confidence: 99%
“…However, recent studies have suggested that long-term exposure to the chemical can cause toxicity in pregnant rats, with bone development deficiency in the fetus (Dallegrave, 2003), changes in cellular metabolism (Marc et al , 2004a; 2004b), cutaneous lesions (Amerio et al , 2004), and increased rates of non-Hodgkin's lymphoma (De Ross et al , 2003). Furthermore, studies using low doses of glyphosate-Biocarb ® have shown that the product can cause significant hepatic changes, as well as nasal bleeding without interfering in platelet aggregation (Benedetti et al , 2004; Neiva et al , 2010). …”
Section: Introductionmentioning
confidence: 99%
“…Further investigations revealed suppression of platelet levels in the GBH-exposed mice, perhaps due to platelet breakdown and the diminished bone marrow function owing to GBH toxicity. Related studies on human subjects show that GBH treatment inhibited platelets aggregation ( Neiva et al, 2010 ); posing a significant risk factor for patients on blood thinning medications.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the procoagulant proteins are involved in haemostasis consolidation. Studies have shown an inhibition of platelet aggregation, with a decrease in ATP secretion by platelets caused by the mechanism involved in the anti-platelet aggregation effect of glyphosate 46 . Studies with rural workers using sprays of pesticides organophophorus report-ed that there was a significant decrease in mean haemoglobin, haematocrit and platelet count at the end of the day after use of sprays by rural workers 47 .…”
Section: Brand Name Active Principlementioning
confidence: 99%