2012
DOI: 10.2478/v10102-012-0022-5
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Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

Abstract: We evaluated the toxicity of hepatic, hematological, and oxidative effects of glyphosate-Roundup® on male and female albino Swiss mice. The animals were treated orally with either 50 or 500 mg/kg body weight of the herbicide, on a daily basis for a period of 15 days. Distilled water was used as control treatment. Samples of blood and hepatic tissue were collected at the end of the treatment. Hepatotoxicity was monitored by quantitative analysis of the serum enzymes ALT, AST, and γ-GT and renal toxicity by urea… Show more

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Cited by 97 publications
(61 citation statements)
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“…Tumor promoting potential of G on 7,12-Dimethylbenz(a)anthracene initiated skin carcinogenesis, No initiating potential (Jasper et al, 2012) Swiss (F and M) R 15d 50 or 500…”
Section: Product Testedmentioning
confidence: 99%
“…Tumor promoting potential of G on 7,12-Dimethylbenz(a)anthracene initiated skin carcinogenesis, No initiating potential (Jasper et al, 2012) Swiss (F and M) R 15d 50 or 500…”
Section: Product Testedmentioning
confidence: 99%
“…Many commercial products containing glyphosate as the active ingredient have been used worldwide due to their effectiveness and relatively low toxicity to humans and other animals (Jasper et al, 2012). As an herbicide, glyphosate inhibits the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme, which acts in the biosynthesis of aromatic amino acids and of shikimic acid.…”
Section: Introductionmentioning
confidence: 99%
“…With the increased use of glyphosate-containing herbicides, such as Touchdown ® (TD; Syngenta) and Roundup ® (Monsanto), many current studies are finally beginning to examine the potential toxicity of the commercially available formulations, and not just the active ingredient or the putative surfactants and associated vehicle(s) [14,32,38]. Using C. elegans as a model organism, our lab has focused on the potential neurotoxicity of TD, as obtainable by industrial and household pesticide applicators [45,46].…”
Section: Discussionmentioning
confidence: 99%