In-Vitro Cytotoxicity Study: Cell Viability and Cell Morphology of Carbon Nanofibrous Scaffold/Hydroxyapatite Nanocomposites

El-Aziz, Asmaa M. Abd; El‐Maghraby, Azza; Ewald, Andrea; Kandil, Sherif

doi:10.3390/molecules26061552

Cited by 13 publications

(20 citation statements)

References 25 publications

(38 reference statements)

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“…Additionally, the results of immersion into SBF solution revealed that most changes in the Ca/P ratio were found for the HAp70/BG30 sample, indicating the highest bioactivity of all samples. These results agree with previous research [46,47].…”

Section: In Vitro Bioactivity Of the Composite Cementssupporting

confidence: 94%

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Ebrahimi

Sipaut

2021

Nanomaterials

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Composite scaffolds of hydroxyapatite (HAp) nanoparticles and bioactive glass (BG) have been applied as appropriate materials for bone tissue engineering. In this study, hydroxyapatite/bioglass cement in different ratios was successfully fabricated. To prepare HAp and HAp/BG cement, synthesized HAp and HAp/BG powder were mixed in several ratios, using different concentrations of sodium hydrogen phosphate (SP) and water as the liquid phase. The liquid to powder ratio used was 0.4 mL/g. The results showed that setting time increased with BG content in the composite. The results also showed that with the addition of bioglass to the HAp structure, the density decreased and the porosity increased. It was also found that after immersion in simulated body fluid (SBF) solution, the compressive strength of the HAp and HAp/BG cements increased with BG concentration up to 30 wt.%. SEM results showed the formation of an apatite layer in all selected samples after immersion in SBF solution. At 30 wt.% BG, greater nucleation and growth of the apatite layer were observed, resulting in higher bioactivity than pure HAp and HAp/BG in other ratios.

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Section: In Vitro Bioactivity Of the Composite Cementssupporting

confidence: 94%

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Ebrahimi

Sipaut

2021

Nanomaterials

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“…The biocompatibility of nanobers was demonstrated in the literature towards several types of normal cells; recently, mouse broblast exhibited high viability upon treatment with electrospun carbon nanobers modied with hydroxyapatite. 73 Our results indicate the biocompatibility of GNR-containing nanobers, particularly those containing a low concentration of GNR.…”

Section: Development Optimization and Characterization Of The Base Polymeric Nanobersmentioning

confidence: 53%

“…The biocompatibility of nanofibers was demonstrated in the literature towards several types of normal cells; recently, mouse fibroblast exhibited high viability upon treatment with electrospun carbon nanofibers modified with hydroxyapatite. 73 …”

Section: Resultsmentioning

confidence: 99%

Quercetin-gold nanorods incorporated into nanofibers: development, optimization and cytotoxicity

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…Electrospun non-woven wound materials have been extensively studied. Because they can be designed to prevent bacterial invasion, promote cell proliferation, as well as adsorption of wound exudates and dehydration of the wound surface 8,9 . Furthermore, because of their microporous nature, they can act as the extracellular matrix (ECM) by promoting cell adhesion and migration 10,11 .Nanofibers for wound dressing come in a variety of shapes and sizes, they can be prepared from a variety of polymers (natural or synthetic), or they are made by blinding more than one type.…”

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confidence: 99%

Electrospun non-wovens potential wound dressing material based on polyacrylonitrile/chicken feathers keratin nanofiber

Serag

El-Aziz

El‐Maghraby

et al. 2022

Sci Rep

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Electrospinning nanofibers have a tremendous interest in biomedical applications such as tissue engineering, drug administration, and wound healing because of their ability to replicate and restore the function of the natural extracellular matrix found in tissues. The study’s highlight is the electrospinning preparation and characterization of polyacrylonitrile with chicken feather keratin as an additive. In this study, keratin was extracted from chicken feather waste using an environmentally friendly method and used to reinforce polymeric nanofiber mats. Scanning electron microscopy, energy dispersive spectroscopy, and transmission electron microscopy were used to examine the morphology and the structure of the prepared nanofiber mats. The effect of keratin on the porosity and the tensile strength of reinforcing nanofibers is investigated. The porosity ratio of the nanofiber mats goes up from 24.52 ± 2.12 for blank polyacrylonitrile (PAN (NF)) to 90.89 ± 1.91% for polyacrylonitrile nanofiber with 0.05 wt% keratin (PAN/0.05% K). Furthermore, keratin reinforcement improves the nanofiber's mechanical properties, which are important for wound dressing application, as well as its antibacterial activity without causing hemolysis (less than 2%). The best antibacterial activities were observed against Pseudomonas aeruginosa (30 ± 0.17 mm inhibition zone) and Staphylococcus aureus (29 ± 0.31 mm inhibition zone) for PAN/0.05% K sample, according to the antibacterial test. This research has a good potential to broaden the use of feather keratin-based nanofibers in wound healing.

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In-Vitro Cytotoxicity Study: Cell Viability and Cell Morphology of Carbon Nanofibrous Scaffold/Hydroxyapatite Nanocomposites

Cited by 13 publications

References 25 publications

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

The Effect of Liquid Phase Concentration on the Setting Time and Compressive Strength of Hydroxyapatite/Bioglass Composite Cement

Quercetin-gold nanorods incorporated into nanofibers: development, optimization and cytotoxicity

Electrospun non-wovens potential wound dressing material based on polyacrylonitrile/chicken feathers keratin nanofiber

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