In vitro characterization of polyesters of aconitic acid, glycerol, and cinnamic acid for bone tissue engineering

Kanitkar, Akanksha; Chen, Cong; Smoak, Mollie M.; Hogan, Katie; Scherr, Thomas; Aita, Giovanna M.; Hayes, Daniel J.

doi:10.1177/0885328214553961

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…In this study, aconitic acid, glycerol and cinnamic acid (Fig. ) were polymerized to yield a hyperbranched polyester product as reported by Kanitkar et al in a similar study . Polymers with excess –OH groups, −COOH groups, and equal number of both groups were synthesized, and the effect on the growth of stem cells was analyzed.…”

Section: Resultssupporting

confidence: 84%

“…1) were polymerized to yield a hyperbranched polyester product as reported by Kanitkar et al in a similar study. 29 Polymers with excess -OH groups, −COOH groups, and equal number of both groups were synthesized, and the effect on the growth of stem cells was analyzed. It was observed via alamarBlue ® and picogreen assays (discussed later), that the amount of cinnamic acid seemed to have a profound effect on cell survival and growth profiles.…”

Section: Synthesis Of Polyestersmentioning

confidence: 99%

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Synthesis of novel polyesters for potential applications in skin tissue engineering

Kanitkar

Smoak

Chen

et al. 2015

J of Chemical Tech & Biotech

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BACKGROUND In this study, polyesters of glycerol, aconitic acid and cinnamic acid were synthesized and studied for their potential application as scaffolds in tissue engineering. Aconitic acid can be recovered from molasses, while glycerol and cinnamic acid can be recovered from pretreated sugarcane bagasse used for bio‐ethanol production. Polyester synthesis was carried out at different molar ratios of reactants at a temperature of 120 °C for 5 h. Synthesized polyesters were characterized chemically and mechanically, and evaluated for their cytotoxicity and chemical stability towards human adipose derived mesenchymal pluripotent stem cells (hASC). RESULTS Several cytocompatibility tests such as mass loss over a period of time, alamar blue to analyze growth and viability of hASC on polyester scaffolds, picogreen for total DNA content synthesized, indicated that these polyesters hold promise as tissue engineering scaffolds. For skin tissue engineering, especially for wound repair, thin film polyester scaffolds laden with hASC were grown in stromal medium supplemented with basic fibroblast growth factor (bFGF). For all the scaffolds, the amount of collagen synthesized in bFGF supplemented medium was significantly higher than the scaffolds with hASC in control (stromal) medium (P<0.05) CONCLUSION Based on the amount of collagen synthesized and DNA quantification data, it was concluded that the polyesters are cytocompatible and support fibroblastic differentiation by the addition of bFGF. © 2015 Society of Chemical Industry

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Section: Resultssupporting

confidence: 84%

Section: Synthesis Of Polyestersmentioning

confidence: 99%

Synthesis of novel polyesters for potential applications in skin tissue engineering

Kanitkar

Smoak

Chen

et al. 2015

J of Chemical Tech & Biotech

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“…44 Cinnamic acid could be a part of osteogenic stimulant composite. 45 Naringenin had stimulant effects on bone similar to estrogen. 46 All these components could be the possible cause for osteoblast stimulation to form new bone.…”

Section: Discussionmentioning

confidence: 99%

Improvements of alveolar bone healing using Moringa oleifera leaf powder and extract biomimetic composite: an experimental study in dogs

Behairy

Ramadan²,

Rouby

et al. 2019

Egyptian Dental Journal

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Alveolar ridge preservation techniques and biomaterials were extensively used in the past few years. The rate of new bone formation is the concept in healing sockets. The faster the rate the lesser the alveolar bone resorption. Resorption is fastened in the first three months after extraction. Wide range of biomaterials were available, the choice of an ideal material was confusing. Objective: Evaluate the effectiveness of both Moringa Oleifera (MO) leaf powder and extract mixture locally and MO leaf extract repeated injections in fresh extraction sockets of dog. Moreover, identifying bioactive phenolic compounds in dried leaves. Materials and Methods: Eight mongrel dogs were included in this study; two animals were used as control. Six test animals were divided into two groups according to biopsy time (3 and 5 weeks). Each of these groups includes three animals. All animals were subjected to extraction of the third premolar bilaterally, both sides of the test animals (the six) were treated with Moringa Oleifera leaf powder (0.7 gm) and water extract (1ml) mixture. The right side only was subjected to repeated injections of Moringa Oleifera leaf water extract (½ ml) for two times (1 st week and 2 nd week postoperatively for all groups). Trephine bur was used to take biopsy for the purpose of histopathologic examination by H&E and Masson Trichrome stain to quantify new bone formation, and number of inflammatory cells. Results: Bone area percent showed the highest mean value in the right side at 3 weeks and 5 weeks. ANOVA test revealed no significant difference between groups (P=0.43) at 3 weeks, while the difference was significant at 5 weeks (P=0.00). Mean inflammatory cells count were significantly higher mean value in control group at 3 weeks and 5 weeks (P=0.00). Conclusion: Two injections of moringa oleifera aqueous extract of 11.7% concentration improved bone area present significantly at 5 weeks and decreased inflammatory cells at all test periods.

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“…The usual techniques for preparing modified polyesters for artificial bone-substitute materials involve 3D printing [ 51 , 61 , 65 , 66 , 72 , 74 , 75 , 76 ], thermally induced phase separation (TIPS) [ 32 ], salt leaching [ 32 , 69 , 79 ], solvent casting [ 33 , 35 , 77 , 79 ], electrospinning [ 60 , 64 , 70 ], copolymerization [ 31 ], and polycondensation [ 73 ].…”

Section: Orthopedic Applicationsmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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In vitro characterization of polyesters of aconitic acid, glycerol, and cinnamic acid for bone tissue engineering

Cited by 7 publications

References 41 publications

Synthesis of novel polyesters for potential applications in skin tissue engineering

Synthesis of novel polyesters for potential applications in skin tissue engineering

Improvements of alveolar bone healing using Moringa oleifera leaf powder and extract biomimetic composite: an experimental study in dogs

Special Features of Polyester-Based Materials for Medical Applications

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