Alveolar ridge preservation procedures became a famous procedures after tooth extraction. Different approaches and materials had been studied. Faster and new bone formation is the concept. Objective: To evaluate the early stages of alveolar bone healing of tooth extraction sockets filled with bioactive composite (chitosan-bioactive glass) CH-MB scaffold soaked in hyaluronic acid (HAL) in a canine model. Materials and Methods: Six mongrel dogs were involved in this study; they were divided into two groups according to sacrifice time (three and six weeks). Each of these groups includes three animals. Animals were subjected to extraction of the third premolar bilaterally. The right extraction socket received bioactive composite (chitosan-bioactive glass) CH-MB scaffold soaked in 0.2 % hyaluronic acid, while the left side had received chitosan-bioactive glass scaffold CH-MB only. The healing extraction sockets were evaluated by (Fourier Transfer Infra-Red spectroscopy) FTIR; where three variables were studied: Matrix quality, degree of crystallinity and degree of calcifications. Results: Hyaluronic acid (HLA) treated groups showed significant results at 6 weeks over all other groups as regard collagen content and crystal maturity. While, degree of calcification showed non-significant results. Moreover, HLA groups showed significant increase from 3 weeks to 6 weeks over non treated groups. Conclusion: Hyaluronic acid was effective in extraction socket healing as regard collagen content at 3 and 6 weeks and crystal maturity especially at 6 weeks. While degree of calcification was negatively affected. It was postulated that HLA sustained its release on the biocomposite scaffold for 6 weeks postoperatively.
Alveolar ridge preservation techniques and biomaterials were extensively used in the past few years. The rate of new bone formation is the concept in healing sockets. The faster the rate the lesser the alveolar bone resorption. Resorption is fastened in the first three months after extraction. Wide range of biomaterials were available, the choice of an ideal material was confusing. Objective: Evaluate the effectiveness of both Moringa Oleifera (MO) leaf powder and extract mixture locally and MO leaf extract repeated injections in fresh extraction sockets of dog. Moreover, identifying bioactive phenolic compounds in dried leaves. Materials and Methods: Eight mongrel dogs were included in this study; two animals were used as control. Six test animals were divided into two groups according to biopsy time (3 and 5 weeks). Each of these groups includes three animals. All animals were subjected to extraction of the third premolar bilaterally, both sides of the test animals (the six) were treated with Moringa Oleifera leaf powder (0.7 gm) and water extract (1ml) mixture. The right side only was subjected to repeated injections of Moringa Oleifera leaf water extract (½ ml) for two times (1 st week and 2 nd week postoperatively for all groups). Trephine bur was used to take biopsy for the purpose of histopathologic examination by H&E and Masson Trichrome stain to quantify new bone formation, and number of inflammatory cells. Results: Bone area percent showed the highest mean value in the right side at 3 weeks and 5 weeks. ANOVA test revealed no significant difference between groups (P=0.43) at 3 weeks, while the difference was significant at 5 weeks (P=0.00). Mean inflammatory cells count were significantly higher mean value in control group at 3 weeks and 5 weeks (P=0.00). Conclusion: Two injections of moringa oleifera aqueous extract of 11.7% concentration improved bone area present significantly at 5 weeks and decreased inflammatory cells at all test periods.
Grafting materials are important for ridge preservation procedures after tooth extraction. Ridge preservation prime value is the volume preservation for the healing sockets, which is needed for different ridge augmentation procedures.Objective: Determine the healing responses of (local growth hormone, and biphasic calcium phosphate mixture 60/40 in fresh extraction sockets of a canine model. Materials and Methods:Six mongrel dogs included in this study; they were divided into 2 groups according to the time of sacrifice (4 and 8 weeks). Each of these groups includes three animals. Animals subjected to extraction of the fourth premolar bilaterally, The right side treated with a mixture of 4 IU (1.6 mg) Growth hormone and biphasic calcium phosphate (a composite of hydroxyapatite HA and bèta-tricalcium phosphate TCP 1 x 0.15 ml (450-650 µm) in a granular form, while the left side left as a control. The healing extraction sockets were evaluated by surface electron microscope (SEM).Results: Scanning electron microscope examination showed homogenous new bone formation in both groups. Control group showed significant results as regard calcium phosphate ratio in the first month, while non-significant result was encountered in the second month between two groups. Conclusion:. Single local dose of growth hormone mixed with 60/40 biphasic calcium phosphate did not improve calcium phosphate ratio.
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