In vitro biocompatibility of anodized titanium with deposited silver nanodendrites

Abstract

Engineers searching new dental biomaterials try to modify the structure of the material in order to achieve the best performance as well as increased migration and proliferation of cells involved in the osseointegration of the implant. In this work we show in vitro test results of the Ti, which was anodically oxidized at high voltages with additionally deposited silver in the form of nanodendrites. The in vitro cytocompatibility of these materials was evaluated and compared with a conventional microcrystalline titanium. During the studies, established cell line of human gingival fibroblasts (HGF) and osteoblasts were cultured in the presence of tested materials, and its survival rate and proliferation activity were examined. Titanium samples modified with silver has a higher degree of biocompatibility in comparison with the unmodified reference material. Cells in contact with studied material showed a higher relative viability potential, stable level of proliferation activity, and lower rate of mortality. Biocompatibility tests carried out indicate that the anodically oxidized titanium at high voltages with additionally deposited nanosilver could be a possible candidate for dental implants and other medicinal applications.

Corrosion Properties of Anodized Titanium

“…of anodization. Potentiodynamic polarization was performed for each sample to find corrosion rate and polarization resistance values [15][16][17][18][19][20]. …”

Bio-Functional Design, Application and Trends in Metallic Biomaterials

“…Studies have indicated that the printed scaffolds demonstrated tensile mechanical property values very similar to those of natural bone, indicating its promise for bone replacement. Based on these preliminary studies, researchers believe that 3D printing will be a promising technology for manufacturing BM products [ 61 , 62 , 63 ]. Figure 8 shows some porous orthopedic implants fabricated by 3D printing technology.…”

Ultrafine-Grained Ti-31Mo-Type Composites with HA and Ag, Ta2O5 or CeO2 Addition for Implant Applications

“…One possibility to enhance the mechanical, corrosion, and biological properties of implant materials, except the chemical composition modification, is the microstructure control via severe plastic deformation (SPD) [ 28 , 29 ] or mechanical alloying (MA) processing methods [ 11 , 12 , 15 , 16 , 17 , 18 , 19 ]. Published results proved that the nano- or ultrafine grain microstructure of titanium and its alloys improved the mechanical properties as well as the biocompatibility [ 18 , 19 , 29 , 30 , 31 , 32 ].…”

“…Biomaterials with nano- or ultrafine- grains offer an interesting property for new products in medical applications [ 4 , 10 , 15 , 16 , 17 , 18 , 19 , 28 , 29 , 30 , 31 , 32 , 35 ]. Our previous studies confirmed that Ti or Ni-free 316L stainless steel—hydroxyapatite composites exhibit superior properties due to the nanostructure.…”