In vitro assessment on medicinal properties and chemical composition of Michelia nilagirica bark

Venkatadri, Babu; Khusro, Ameer; Aarti, Chirom; Rameshkumar, Marimuthu Ragavan; Agastian, Paul

doi:10.1016/j.apjtb.2017.08.003

Cited by 23 publications

(9 citation statements)

References 24 publications

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“…In the antioxidant traits, aqueous and ethanolic extracts showed varied ranges of DPPH scavenging activities. The present findings agreed with the reports of Venkatadri et al (2017) who illustrated pronounced degradation of DPPH at disparate concentrations of the extracts. However, this investigation uncovered that aqueous extract elicited the potent antioxidant activity, linking the fact that active phytochemicals of P. granatum fruits peel are readily dissolved in an aqueous medium.…”

Section: Discussionsupporting

confidence: 93%

“…In this investigation, the DPPH degrading potential of aqueous extract suggests the availability of many hydroxyl groups in the structure of saponins as contained in the aqueous extract than ethanolic, acetone, chloroform, and petroleum ether extracts responsible for the enhancement of antioxidant activity in DM ( Elekofehinti, 2015 ). Hydrogen peroxide deactivates enzymes by the oxidation of essential thiol (-SH) groups and reacts with Fe 2+ similar to Cu 2+ ions for forming hydroxyl radicals ( Venkatadri et al, 2017 ). In this study, P. granatum peel extracts showed moderate scavenging of H 2 O 2 which might be due to glycosides found in the extracts.…”

Section: Discussionmentioning

confidence: 99%

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Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties

Mayasankaravalli¹,

Deepika²,

Lydia³

et al. 2020

Saudi Journal of Biological Sciences

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This context was investigated to assess the in vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme (ACE) inhibition traits of Punica granatum fruits peel extract. Initially, among various extracts tested, aqueous and ethanolic peel extracts depicted the presence of diverse phytoconstituents. In vitro antioxidative properties of peel extracts were determined using standard methodologies. Results showed that aqueous and ethanolic extracts had IC 50 values of 471.7 and 509.16 μg/mL, respectively in terms of 1,1,diphenyl 2,2,picrylhydrazyl scavenging. Likewise, IC 50 values of aqueous and ethanol extract were obtained as 488.76 and 478.47 μg/mL towards the degradation of hydrogen peroxide. The ethanolic extract exhibited the highest inhibition of α - glucosidase by showing activity of 53.34 ± 2.0 to 15.18 ± 1.4 U/L in a dose dependent manner (100–1000 µg/mL). Ethanolic extract was reported as the most active inhibitor of lipase with an IC 50 value of 603.50 µg/mL. Ethanolic extract showed increased inhibition of ACE in a concentration dependent manner (100–1000 µg/mL) with IC 50 value of 519.45 µg/mL. Fourier transform-infrared spectrum revealed the availability of various functional groups in the ethanolic extract of peel. Gas chromatography-mass spectrometry chromatogram of peel extract illustrated 23 diversified chemical constituents including 1,2,3,4-butanetetrol, Dimethyl sulfone, 9-octadecenamide, and Pentadecanoic acid as predominant compounds. In summary, P. granatum fruits peel extract revealed promising antioxidant, anti-diabetic, anti-obesity, and anti-hypertensive properties.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties

Mayasankaravalli¹,

Deepika²,

Lydia³

et al. 2020

Saudi Journal of Biological Sciences

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“…Naragani et al (2016) revealed the first report on 1-tridecene, a bioactive compound from the genus of Streptomyces, Streptomyces cheonanensis VUK-A isolated from mangrove ecosystem that exhibited moderate to significant antimicrobial activity. Besides that, Venkatadri et al (2017), reported 1-tridecene is one of the chemical constituent found in the ethyl acetate extract of Michelia nilagirica bark and they postulated that the extract possesses good antibacterial activity. This compound also has been reported to attribute aroma in plant essential oil.…”

Section: Gas Chromatography-mass Spectrometry (Gc-ms)mentioning

confidence: 98%

Volatile Bioactive Compounds from Lasiodiplodia pseudotheobromae IBRL OS-64, an Endophytic Fungus Residing in the Leaf of Ocimum sanctum

Jalil

Demirtaş

2022

HAYATI J Biosci

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Endophytic fungi are known as potential novel compound producers with promising antimicrobial activities. Hence, the present study aimed to investigate the possible bioactive compounds present in the ethyl acetate extract of Lasiodiplodia pseudotheobromae IBRL OS-64. The ethyl acetate extract exhibited significant antibacterial activity against both Gram-positive and Gram-negative bacteria in disc diffusion assay. Thin-layer chromatography (TLC) was performed with chloroform, acetone and ethyl acetate (1:2:1, respectively) used as a solvent system and nine spots with diverse polarities were obtained. The TLC chromatogram with the active spot was localized with bioautography assay and the finding revealed that the dark spot with an Rf value of 0.5882 showed good antibacterial activity against all test bacteria. The fraction F5 exhibited promising antibacterial activity upon partial purification of dark spot via column chromatography and the GC-MS analysis of fraction F5 resulted in the detection of a major compound, 2-Benzenedicarboxylic acid, mono (2-ethylhexyl) ester with 90% matching factor. Thus, this compound may greatly contribute to the antibacterial activity of the fraction and has the potential to be developed as an antibiotic. The findings indirectly indicate that fungal endophytes from the medicinal plant could be a potential candidate for bioactive compounds with pharmaceutical properties.

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“…This could be explained by the differences of species and plant parts, but solvents may also play an important role, as the ethyl acetate extract of M. nilagirica contained more TPC and TFC than the hexanic and methanolic extracts. [13]…”

Section: Total Phenolic Contents and Total Flavonoid Contentsmentioning

confidence: 99%

“…Previous study certified that the methanol extract of M. nilagirica bark had a weaker inhibitory effect on α-glucosidase than the ethyl acetate extract and hexane extract. [13] More precisely, these influences may be closely related to the polyphenol compounds. Pearson correlation analysis results (Figure 3) showed that the inhibitory activities of α-amylase and α-glucosidase have strong correlation with chlorogenic acid, vanillic acid, caffeic acid and ferulic acid.…”

Section: In Vitro Inhibition Of α-Amylase and α-Glucosidasementioning

confidence: 99%

Leaf and Flower Extracts of Six Michelia L.: Polyphenolic Composition, Antioxidant, Antibacterial Activities and in Vitro Inhibition of α‐Amylase and α‐Glucosidase

Liao

Cao

Yang

et al. 2022

Chemistry & Biodiversity

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Methanolic extracts of the leaf and flower of Michelia L., an evergreen aromatic genus widely used in landscaping, industry and medicine of various countries, were analyzed. The UPLC-ESI-MS/MS analysis led to the identification of 28 polyphenols from six Michelia species that widely distributed and cultivated in southern China, among which quinic acid and chlorogenic acid were the main components. The flower extract of Michelia maudiae had the most abundant polyphenols content, as well as high contents of total phenolic (117.31 � 7.26 mg GAE/g DW) and total flavonoid (251.60 � 15.56 mg CE/g DW). Meanwhile, it also showed outstanding performance in three antioxidant indexes of DPPH, ABTS and FRAP. The leaf extracts of Michelia chapensis and Michelia floribunda exhibited excellent inhibition against four pathogenic bacteria. Moreover, certain inhibitory activities were displayed by Michelia macclurei extracts against α-amylase and α-glucosidase. This study explored the biological activities of six Michelia species, and provided reference for variety selection with the aim of designing novel phyto-pharmaceuticals.

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In vitro assessment on medicinal properties and chemical composition of Michelia nilagirica bark

Cited by 23 publications

References 24 publications

Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties

Profiling the phyto-constituents of Punica granatum fruits peel extract and accessing its in-vitro antioxidant, anti-diabetic, anti-obesity, and angiotensin-converting enzyme inhibitory properties

Volatile Bioactive Compounds from Lasiodiplodia pseudotheobromae IBRL OS-64, an Endophytic Fungus Residing in the Leaf of Ocimum sanctum

Leaf and Flower Extracts of Six Michelia L.: Polyphenolic Composition, Antioxidant, Antibacterial Activities and in Vitro Inhibition of α‐Amylase and α‐Glucosidase

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