volume 44, issue 8, P3149-3154 2010
DOI: 10.1021/es903029j
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Arno C. Gutleb, Peter Cenijn, Martin van Velzen, Elisabeth Lie, Erik Ropstad, Janneche Utne Skaare, Tina Malmberg, Åke Bergman, Geir W. Gabrielsen, Juliette Legler

Abstract: Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no bin…

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