In vitro antiplasmodial and antioxidant activities of bisbenzylisoquinoline alkaloids from Alseodaphne corneri Kosterm

Zahari, Azeana; Ablat, Abdulwali; Sivasothy, Yasodha; Mohamad, Jamaludin; Choudhary, M. Iqbal; Awang, Khalijah

doi:10.1016/j.apjtm.2016.03.008

Cited by 43 publications

(31 citation statements)

References 21 publications

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“…Alkaloid compounds can stop free radical chain by donating H atoms in free radicals. 17 Then, the anthraquinone compounds are known to have antioxidant activity through reducing the hydroxyl radical. 18 Tetraterpen compounds such as terpenoids and carotenoids have antioxidant activity both in vitro and in vivo.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Antioxidant Activity and Lipoxygenase Inhibition Test with Total Flavonoid Content from Garcinia kydia Roxburgh Leaves Extract

Putri

Elya²,

Puspitasari

2017

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Introduction: Antioxidant is one of the therapeutic strategies to overcome oxidative stress and inhibit synthesis of inflammatory mediators through lipoxygenase pathway. Garcinia is the largest of Clusiaceae family which has been proven to provide antioxidant and anti-inflammatory activity. Garcinia kydia Roxburgh is one of the plants of this genus which is known to have antioxidant activity but lipoxygenase inhibition activity from this plant was unknown. Methods: This study aimed to test antioxidant activity of the methanol, ethyl acetate and n-hexane extract from Garcinia kydia Roxburgh leaves by FRAP (Ferric Reducing Antioxidant Power) method, anti-inflammatory activity was tested by inhibiting lipoxygenase and total flavonoid content by colorimetric methods AlCl3. Results: The results showed an antioxidant activity of methanol extract, ethyl acetate and n-hexane leaves of Garcinia kydia Roxburgh have EC 50 value, respectively 18,448; 12,389 and 31,260 µg/mL, and the lipoxygenase inhibition activity have IC 50 value, respectively 0,556; 0,212 and 3,575 µg/mL. Ethyl acetate extract of Garcinia kydia Roxburgh leaves was the most active extract in this study which has total flavonoid content, 30,650 mgQE/ gram extract. Conclusion: The conclusion, Garcinia kydia Roxburgh has antioxidant and lipoxygenase inhibition activity, with ethyl acetate extract as the most active extract which contains total flavonoids.

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Section: Antioxidant Activitymentioning

confidence: 99%

Antioxidant Activity and Lipoxygenase Inhibition Test with Total Flavonoid Content from Garcinia kydia Roxburgh Leaves Extract

Putri

Elya²,

Puspitasari

2017

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“…Phenolic acids and flavonoids have been reported in this seagrass. 3,4,5 The phenolics were reported capable of scavenging free radical chain by donating the hydrogen, 17 and flavonoids also contribute to the antioxidant activity because of their hydroxyl functional group at the site of the structure. 18 Extraction played important role in isolating phytochemicals from the plant materials.…”

Section: Discussionmentioning

confidence: 99%

Optimization of Extraction Condition to Obtain Antioxidant Activity and Total Phenolic Content of Seagrass Thalassia hemprichii (Ehrenb.) Asch from Indonesia

Nopi¹,

Anwar²,

Nurhayati³

2018

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Background: Thalassia hemprichii (Ehrenb.) Asch is one of the commonly found seagrasses spread over the coast of Indonesia and has not been utilized. Previous studies have reported its potency as an antioxidant, however, studies on optimal extraction conditions using ethanol as a solvent to obtain higher antioxidant activity are still limited. Objective: The purpose of this study is to optimize the extraction condition for obtaining the highest antioxidant activity and total phenolic content of the seagrass T. hemprichii. In an addition, percentage yield of extract was also evaluated. Methods: In this study, factorial design with independent factors of ethanol concentrations (50%, 70%, and 100%), the use of HCl 1 N (Yes/No), and temperature (30 0 C, 60 0 C) was developed. The analysis of variance (ANOVA) was used to determine the significance of the above factors towards antioxidant activity and total phenolic content. The antioxidant activity was evaluated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and the total phenolic content was determined by Folin-Ciocalteu method. Re sults: The highest antioxidant activity (IC 50 =83.48 μg/mL) was shown in sample R1 (extracted with 50% ethanol, added with HCl 1 N, and 60 0 C). The sample was also showed total phenolic content 41.03 mg GAE per gram and 22% yield extract. Among the factors examined, the used of HCl 1 N showed the most significant effect to the antioxidant activity and the total phenolic content, with the p-value of 0.048 and 0.034 respectively (p<0.05). Conclusion: This extraction condition can be applied to obtain higher antioxidant activity and total phenolic content from the plant.

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“…Alkaloids compounds are discovered can stop free radical chain by donating H atoms in free radicals. 12 Ferric reducing ability of plasma and metal chelating assays. Results: Malaria infection caused the formation of free radicals which dihydrochalcones and flavonols The use of water with other organic solvents as a combination contributes to the formation of fairly small polar media ensuring the extraction of polyphenols.…”

Section: Discussionmentioning

confidence: 99%

In-vitro Evaluation of Antioxidant Activity and Anti-collagenase Activity of Thalassia hempricii as a Potent Ingredients for Anti-Wrinkle Cosmetics

Zakiah

Anwar²,

Nurhayati

2018

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Background:Thalassia hemprichii have reported containing antioxidant effects. However, information on other biological activities relating to the anti-wrinkle properties is limited. The free radical scavenging activity and enzyme inhibitory activity of the plant extracts investigated that they can help restore skin elasticity and thereby slow the wrinkling process. Objective: To evaluate in-vitro antioxidant and anti-collagenase activity of T. hemprichii as a potent ingredient for anti-wrinkle cosmetic. Methods: T. hemprichii was extracted with ethanol 100% (E1) 75% (E2) and ethanol 50% (E3) using maceration extraction method for 24 h, thrice. The extract was examined for total phenolic content, antioxidant activity compared with vitamin C, and the best extract was tested for the inhibitory activity of collagenase. Results: The total phenolic content of T. hempricii extract was 0,525 ± 0,016 mg GAE/100 g extract (E1) 0,538 ± 0,006 mg GAE/100 g extract (E2) and 0,558 ± 0,090 mg GAE/100 g extract (E3) respectively. The antioxidant activity (% inhibition) of the extract was 38,035 ± 0,252 % (E1), 52,502 ± 6,225 % (E2) and 57,261 ± 0,505 % (E3). Ascorbic acid as a positive control of antioxidant activity showed much higher % inhibition than the sample with 78,055 ± 0,756 %. As the best extract from antioxidant activity, E2 and E3 have inhibited collagenase activity with 51,809 ± 0,164 % and 52,212 ± 0,735 % at 20μg/mL respectively. Conclusion: In general the (T. hempricii) extract can be used as a potential active ingradient for anti-wrinkles cosmetic.

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In vitro antiplasmodial and antioxidant activities of bisbenzylisoquinoline alkaloids from Alseodaphne corneri Kosterm

Cited by 43 publications

References 21 publications

Antioxidant Activity and Lipoxygenase Inhibition Test with Total Flavonoid Content from Garcinia kydia Roxburgh Leaves Extract

Antioxidant Activity and Lipoxygenase Inhibition Test with Total Flavonoid Content from Garcinia kydia Roxburgh Leaves Extract

Optimization of Extraction Condition to Obtain Antioxidant Activity and Total Phenolic Content of Seagrass Thalassia hemprichii (Ehrenb.) Asch from Indonesia

In-vitro Evaluation of Antioxidant Activity and Anti-collagenase Activity of Thalassia hempricii as a Potent Ingredients for Anti-Wrinkle Cosmetics

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