In Vitro Antimicrobial and Antioxidant Activity of Ethanol Extract of Three<i>Hypericum</i>and Three<i>Achillea</i>Species From Turkey

Barış, Deniz; Kızıl, Murat; Aytekin, Çetin; Kızıl, Göksel; Yavuz, Murat; Çeken, Bircan; Ertekin, A. Selçuk

doi:10.1080/10942910903189256

Cited by 62 publications

(34 citation statements)

References 56 publications

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“…As highlighted by the results obtained using the ABTS (IC 50 22.49 ± 2.01 mg/mL) and DPPH (IC 50 31.41 ± 3.13 mg/mL) tests, the extract has an interesting electron donor and hydrogen donor potential. These results, along with the aforementioned phenolic composition, are comparable with those reported for other Achillea species (the IC 50 value ranges from 55.0 to 33.0 mg/mL) Barış et al, 2011;Candana et al, 2003). In order to determine the reducing power, the FRAP-Ferrozine (FZ) test was also performed.…”

Section: Resultssupporting

confidence: 66%

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Venditti¹,

Maggi

Vittori

et al. 2015

Pharmaceutical Biology

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Context: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus, and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. Objective: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on a-glucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. Materials and methods: In vitro a-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests) was measured. The extract was characterized from a phytochemical point of view by means of spectroscopic analysis. Results: The extract results endowed with a-glucosidase inhibitory activity (IC 50 32 mg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known a-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds such as caffeoylquinic acids and flavonoids. Discussion and conclusions: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates.

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Section: Resultssupporting

confidence: 66%

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Venditti¹,

Maggi

Vittori

et al. 2015

Pharmaceutical Biology

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“…This assumption is in accordance with previous examinations on various Hypericum species, where it was shown that extracts with higher polyphenolic load also exhibited stronger antioxidant effects [24,25]. Similar results were reported for several Hypericum taxa [26][27][28]. Therefore, the differences in the P R values between the two extracts are rather attributed to differences in the total polyphenol concentration and the relative amounts of the various polyphenols.…”

Section: Antioxidant Activitysupporting

confidence: 80%

Optimisation of organic solvent-free polyphenol extraction from Hypericum triquetrifolium Turra using Box–Behnken experimental design and kinetics

et al. 2015

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Hypericum triquetrifolium Turra is a plant rich in biologically functional polyphenolic phytochemicals. The efficient recovery of polyphenols from this material has not been previously investigated in depth, in terms of establishing an environmentally benign and cost-effective process that would aim at producing extracts enriched in polyphenolic compounds. The objective of the present study was the examination of the efficiency of water/ glycerol mixtures in extracting polyphenols from dried aerial parts of H. triquetrifolium Turra and its critical comparison with water. Extraction temperature and time were optimised using response surface methodology, while comparative assessment of the extraction efficiency between water/glycerol and water was carried out using kinetics. The results showed that 10 % (w/v) aqueous glycerol at 70°C provided very satisfactory extraction yield in total polyphenols (54.83 mg gallic acid equivalents per g of dry weight), which was significantly higher than that attained with water (17.3 %). Similar results were drawn for the reducing power, in concurrence with the polyphenolic concentration. Liquid chromatography-mass spectrometry analysis showed that the polyphenolic profile of water/glycerol extract was composed by polar substances, such as chlorogenic acids and quercetin glycosides.Diffusion (m 2 s -1 ) dw Dry weight (g) h Initial extraction rate (mg g -1 min -1 ) k Extraction rate constant (g mg -1 min -1 ) P R Reducing power (lmol AAE g -1 dw) R Effective particle radius (m)

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“…Antioxidants can reduce Fe +3 to Fe +2 and the colour changes of the solution can be used for evaluating the antioxidant activity of the extract . In this research, the reducing capacities of MeOH extracts of myrtle were compared to BHT ( Table ).…”

Section: Resultsmentioning

confidence: 99%

Essential Oil and Bioactive Compounds Variation in Myrtle (Myrtus communis L.) as Affected by Seasonal Variation and Salt Stress

Shoshtari

Rahimmalek

Hosseini³

2017

Chemistry & Biodiversity

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The effect of different NaCl concentrations (control, 2, 4 and 6 dS/m) and three harvesting times in different seasons including spring (9 April), summer (5 July), and fall (23 September) was evaluated on essential oil (EO) yield, composition, phenolic, flavonoid content, and antioxidant activity of myrtle. Essential oil yield ranged from 0.2% in control and fall to 1.6% in moderate salinity (4 dS/m) and spring season. The main constituents obtained from gas chromatography/mass spectrometry analysis were α-pinene, 1,8-cineole, limonene, linalool, α-terpineol, and linalyl acetate in which α-pinene ranged from 11.70% in moderate and fall to 30.99% in low salinity (2 dS/m) and spring, while 1,8-cineole varied from 7.42% in high salinity (6 dS/m) and summer to 15.45% in low salinity and spring, respectively. Salt stress also resulted in an increase in total phenolic, flavonoid content, and antioxidant activity. The highest antioxidant activity based on DPPH radical scavenging activity, reducing power (FTC) and β-carotene/linoleic acid model systems was found in plants harvested in spring and summer in high stress condition. The lowest IC values obtained in 6 dS/m in spring (375.23 μg/ml) followed by summer (249.41 μg/ml) and fall (618.38 μg/ml). Eight major phenolic and flavonoid compounds were determined in three harvesting times using high performance liquid chromatography analysis. In overall, late harvesting time of myrtle in fall can lead to reduce the most of major EO components, while it can improve the amount of phenolic acids.

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In Vitro Antimicrobial and Antioxidant Activity of Ethanol Extract of ThreeHypericumand ThreeAchilleaSpecies From Turkey

Cited by 62 publications

References 56 publications

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Optimisation of organic solvent-free polyphenol extraction from Hypericum triquetrifolium Turra using Box–Behnken experimental design and kinetics

Essential Oil and Bioactive Compounds Variation in Myrtle (Myrtus communis L.) as Affected by Seasonal Variation and Salt Stress

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