Antioxidant andα-glucosidase inhibitory activities ofAchillea tenorii

Abstract

Context: There is a need for the discovery of novel natural remedies to prevent and treat metabolic disorders such as hyperglycemia, type II non-insulin-dependent diabetes mellitus, and obesity. Several Achillea species have been utilized for centuries all around the world and are generally considered effective as hypoglycemic. Objective: Considering the ethnobotanical uses of Achillea genus, we evaluated the in vitro inhibitory activity of Achillea tenorii Grande (Asteraceae) extract on a-glucosidase, which is a valuable target to prevent and treat metabolic disorders. We also tested its antioxidant activity. Moreover, the phytochemical profile was discussed from a chemotaxonomic point of view. Materials and methods: In vitro a-glucosidase inhibition of crude ethanolic extract obtained from the aerial parts was assayed as well as the in vitro antioxidant activity (ABTS, DPPH, and FRAP-FZ tests) was measured. The extract was characterized from a phytochemical point of view by means of spectroscopic analysis. Results: The extract results endowed with a-glucosidase inhibitory activity (IC 50 32 mg/mL) with a particular mechanism of action definable as un-competitive, which differed from the mechanism observed for the best-known a-glucosidase inhibitor (acarbose and miglitol). In addition, a considerable antioxidant potential has been found for A. tenorii extract, which resulted mainly constituted by phenolic compounds such as caffeoylquinic acids and flavonoids. Discussion and conclusions: These results suggest the potential of A. tenorii as a possible natural remedy to prevent and treat metabolic disorders of carbohydrates.

The Therapeutic Potential of Apigenin

“…Apigenin (4′,5,7-trihydroxyflavone) (Figure 2) is one of the most widespread flavonoids in plants and formally belongs to the flavone sub-class. Plants belonging to the Asteraceae , such as those belonging to Artemisia [15], Achillea [16,17], Matricaria [18], and Tanacetum [19] genera, are the main sources of this compound. However, species belonging to other families, such as the Lamiaceae , for instance, Sideritis [20] and Teucrium [21,22], or species from the Fabaceae , such as Genista [23], showed the presence of apigenin in the aglycone form and/or its C - and O -glucosides, glucuronides, O -methyl ethers, and acetylated derivatives (Figure 2).…”

Diabet Hastalarında Bitkisel Ürün Kullanımı

“…Yeşil çay kateşinlerinin başka bir çalışmada; açlık kan glikozunu önemli ölçüde azalttığı görülmüştür (16). Çalışmamızda hastaların %1,3'ü civanperçemi kullandıklarını söylemiştir, civanperçeminin yapılmış çalışmada antioksidan ve alfa glikozidaz inhibitörü etkisi olduğu ve akarboz benzeri etkisi olduğu görülmüştür (17). Civanperçeminin antioksidan ve hipoglisemik aktivitesinin olduğu sıçanlarda streptozosinle oluşturulan diyabet modelinde gösterilmiştir (18).…”

Sabicea brasiliensis Wernham: Antioxidant Activity, Proliferative Effect and Modulation of Vascular Adenine Nucleotides Metabolism

“…They are found in abundance in the Rubiaceae family, especially in coffee and tea [25]. The antioxidant effects of these molecules have been reported in plants like Achillea tenorii [26] and Hypericum hircinum L [27]. In the vasculature, 3,4-di-O-caffeoylquinic acid from the Taiwanese folk medicine Elephantopus mollis minimized the loss of cell viability induced by oxidative stress in cultured human umbilical vein endothelial cells [28].…”