In vitro Antimicrobial Activities of Different Fractions of 
 Swertia chirata Ethanolic Extract

Alam, Khondoker Dedarul; Sarif, M.; Parvin, Shahnaj; Mahjabeen, Sanjida; Akbar, Mohammad Ahsanul; Ahamed, Rizwan

doi:10.3923/pjbs.2009.1334.1337

Cited by 22 publications

(9 citation statements)

References 16 publications

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“…In concentration of 75%, only S. aureus and E.coli showed inhibition zone a little less than full strength, others revealed no significant inhibition. The results support previous studies [15,3] and showed that antimicrobial activity was best at full concentration.…”

Section: Resultssupporting

confidence: 92%

“…Recent Trends in Herbal Drug Research and Therapy showcases some of these crucial and emerging issues relating to herbal drugs [1]. The use of higher plants and preparations made from them to treat infections is an old-age practice in a large part of the world population, especially in developing countries, where there is dependence on traditional medicine for variety of diseases [2,3]. The economic crisis, high cost of industrialized medicines, inefficient public access to medicinal and pharmaceutical care, in addition to the side effects caused by synthetic drugs are of some of the factors contributing to the central role of medicinal plants in health care [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Different Fractions of Swertia Chirata Against Gram Positive and Gram Negative Bacteria

Nyein

Ismail²,

Rahman³

2013

TOPROCJ

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Complementary and alternative medicine (CAM) is becoming increasingly popular and experienced a high growth all over the world. A medicinal plant, Swertia chirata, has been widely use as herbal medicine in Asian countries and some parts of the world. The aim of this study was to evaluate the antibacterial property of Swertia chirata. Plants were extracted using ethanol. Disc diffusion technique was used to determine antimicrobial activity. Crude extraction of whole plant showed significant antimicrobial activities against some gram positive and gram negative bacteria. Test materials at a concentration of 100 µg disc-1 were used to evaluate the antimicrobial activity and 30 µg disc-1 concentration of Chloramphenicol was used as positive control. Zone of inhibition against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella arizonae were 10mm, 6mm, 9mm and 7mm respectively. Minimum Inhibitory Concentration of the crude extract was determined by serial dilution technique which showed 128 µg/ml, 64 µg/ml, 128 µg/ml and 128 µg/ml respectively. Although the results obtained revealed inhibition against some gram positive and gram negative bacteria, a further study need to be carried out to detect the active compounds of this highly potent plant. Moreover, problems of drug resistance leading to recurrent infections highlight a need to search for new compounds for treatment of microbial infections. Hence, Swertia chirata which possesses antimicrobial activity, hope will complement if not replace a standard antimicrobial drug that will be of benefits to the health of the mankind.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Analysis of Different Fractions of Swertia Chirata Against Gram Positive and Gram Negative Bacteria

Nyein

Ismail²,

Rahman³

2013

TOPROCJ

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“…The varied ethnobotanical uses of S. chirayita have led to the initiation of various pharmacological investigations. Previous research demonstrates that the S. chirayita extracts exhibit a wide range of biological activities, such as antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, and others like antidiabetic and antioxidant activities (Verma et al, 2008 ; Alam et al, 2009 ; Arya et al, 2011 ; Chen et al, 2011 ; Laxmi et al, 2011 ). Concurrently, a diverse range of in vitro and in vivo test systems has been used to evaluate the pharmacological properties of S. chirayita .…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…Evidence-based laboratory investigations indicate that aqueous, alcoholic and methanolic extracts of S. chirayita possess a number of promising pharmacological properties. The whole plant of S. chirayita have been reported to be used for the treatment of antibacterial and antifungal activity (Alam et al, 2009 ; Laxmi et al, 2011 ; Rehman et al, 2011 ). Anti-hepatitis B virus activity of S. chirayita extracts was also studied on HepG 2.2.15 cells line (Zhou et al, 2015 ).…”

Section: Pharmacological Activitymentioning

confidence: 99%

A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal Plant

2016

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Swertia chirayita (Gentianaceae), a popular medicinal herb indigenous to the temperate Himalayas is used in traditional medicine to treat numerous ailments such as liver disorders, malaria, and diabetes and are reported to have a wide spectrum of pharmacological properties. Its medicinal usage is well-documented in Indian pharmaceutical codex, the British, and the American pharmacopeias and in different traditional medicine such as the Ayurveda, Unani, Siddha, and other conventional medical systems. This ethnomedicinal herb is known mostly for its bitter taste caused by the presence of different bioactive compounds that are directly associated with human health welfare. The increasing high usage of Swertia chirayita, mostly the underground tissues, as well as the illegal overharvesting combined with habitat destruction resulted in a drastic reduction of its populations and has brought this plant to the verge of extinction. The increasing national and international demand for Swertia chirayita has led to unscrupulous collection from the wild and adulteration of supplies. The aim of this review is to provide a synthesis of the current state of scientific knowledge on the medicinal uses, phytochemistry, pharmacological activities, safety evaluation as well as the potential role of plant biotechnology in the conservation of Swertia chirayita and to highlight its future prospects. Pharmacological data reported in literature suggest that Swertia chirayita shows a beneficial effect in the treatment of several ailments. However, there is lack of adequate information on the safety evaluation of the plant. The pharmacological usefulness of Swertia chirayita requires the need for conservation-friendly approaches in its utilization. Providing high-quality genetically uniform clones for sustainable use and thereby saving the genetic diversity of this species in nature is important. In this regard, plant biotechnological applications such as micropropagation, synthetic seed production, and hairy root technology can play a significant role in a holistic conservation strategy. In addition to micropropagation, storage of these valuable genetic resources is equally important for germplasm preservation. However, more advanced research is warranted to determine the activities of bioactive compounds in vitro and in vivo, establish their underlying mechanisms of action and commence the process of clinical research.

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“…Common ingredients of swertia species are in a number of herbal remedies. In India, 40 species of Swertia chirata are recorded 5,3,8 antispasmodic, antioxidant, anti-diabetic, antipyretic as well as antitussive activities 10,11,12,13 . Moreover the different medicinal compounds were isolated from natural herbs effecting as anticancer, antitumor and anti AIDS etc.…”

Section: Introductionmentioning

confidence: 99%

Review on Swertia Chirata as Traditional Uses to Its Pyhtochemistry and Phrmacological Activity

Aleem

Kabir

2018

J. Drug Delivery Ther.

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Swertia chirata (Gentianaceae), is a popular medicinal plant native to temperate Himalaya. The plant of Swertia chirata is found at an altitude of 1200-1300m, from Bhutan to Kashmir and in the Khasi hills at 1200-1500m. It also can be grown in sub-temperate territories between 1500-2100m altitudes. Chirata has an erect and about 2-3 ft long stem. Herbal medicinal plants are necessary for about for about 80% of the world population in developed and developing countries for their basic and primary health care required owing to better tolerability, superior empathy with human body and having lesser side effects. Herbal plants are considered as rich source of phytochemical ingredients. The main chemical ingredients are Swertiamarin, Amarogentin, Swechirin, Mangiferin, Sweroside, Gentianine, Amaroswerin, Oleanolic acid, Swertanoone, Ursolic acid. Phytochemical analysis divulges alkaloids, flavonoids, steroids, glycosides, triterpenoids, saponins, xanthones and ascorbic acid in all samples. Nepali S. chirata was found to have finest TLC (thin layer chromatography). People have been using traditional medicinal plants for thousand years ago. Traditional plants play a very important role in preventing and treating of human diseases. Medicinal usage of Swertia chirata is reported in Indian pharmaceutical codex, the American and the British pharmacopoeias and in the different traditional systems of medicine (Unani, Ayurveda and Siddha). Swertia chirata is commonly known as a bitter tonic in traditional system of medicine for the treatment of fever, loss of appetite, digestive disorders, diabetes, skin and various other diseases. Keywords: Swertia chirata, swerchirin, Anti-inflammatory, Oleanolic acid, Traditional medicine.

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In vitro Antimicrobial Activities of Different Fractions of Swertia chirata Ethanolic Extract

Cited by 22 publications

References 16 publications

Analysis of Different Fractions of Swertia Chirata Against Gram Positive and Gram Negative Bacteria

Analysis of Different Fractions of Swertia Chirata Against Gram Positive and Gram Negative Bacteria

A Review of Swertia chirayita (Gentianaceae) as a Traditional Medicinal Plant

Review on Swertia Chirata as Traditional Uses to Its Pyhtochemistry and Phrmacological Activity

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