Review on Swertia Chirata as Traditional Uses to Its Pyhtochemistry and Phrmacological Activity

Aleem, Abdul; Kabir, Hifzul

doi:10.22270/jddt.v8i5-s.1957

Cited by 26 publications

(15 citation statements)

References 19 publications

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“…Catechin, epicatechin, and taxifolin from A. catechu [ 26 , 96 ]; ursolic acid, 2 α -hydroxyursolic acid, asiatic acid, β -sitosterol 3- O - β - D -glucopyranoside, quercetin, ellagic acid, and kaempferol from M. malabathricum [ 55 ]; and amarogentin, amaroswerin, gentianine, mangiferin, oleanolic acid, swechirin, swertiamarin, sweroside, swertanoone, ursolic acid, etc. from S. chirayita [ 102 , 103 ] were identified with antibacterial ability.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Aryal

Niraula

Khadayat

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Natural products have been the center of attraction ever since they were discovered. Among them, plant-based natural products were popular as analgesics, anti-inflammatory, antidiabetic, and cosmetics and possess widespread biotechnological applications. The use of plant products as cosmetics and therapeutics is deep-rooted in Nepalese society. Although there are few ethnobotanical studies conducted, extensive research of these valuable medicinal plants has not been a priority due to the limitation of technology and infrastructure. Here, we selected 4 traditionally used medicinal plants to examine their bioactive properties and their enzyme inhibition potential. α-Glucosidase and α-amylase inhibitory activities were investigated using an in vitro model followed up by antioxidant and antimicrobial activities. The present study shows that ethyl acetate fraction of Melastoma melabathrium (IC50 9.1 ± 0.3 µg/mL) and water fraction Acacia catechu (IC50 9.0 ± 0.6 µg/mL) exhibit strong α-glucosidase inhibition. Likewise, the highest α-amylase inhibition was shown by crude extracts of Ficus religiosa (IC50 29.2 ± 1.2 µg/mL) and ethyl acetate fractions of Shorea robusta (IC50 69.3 ± 1.1 µg/mL), and the highest radical scavenging activity was shown by F. religiosa with an IC50 67.4 ± 0.6 µg/mL. Furthermore, to identify the metabolites within the fractions, we employed high-resolution mass spectrometry (LC-HRMS) and annotated 17 known metabolites which justify our assumption on activity. Of 4 medicinal plants examined, ethyl acetate fraction of S. robusta, ethyl acetate fraction of M. melabathrium, and water or ethyl acetate fraction of A. catechu extracts illustrated the best activities. With our study, we set up a foundation that provides authentic evidence to the community for use of these traditional plants. The annotated metabolites in this study support earlier experimental evidence towards the inhibition of enzymes. Further study is necessary to explore the clinical efficacy of these secondary molecules, which might be alternatives for the treatment of diabetes and pathogens.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Aryal

Niraula

Khadayat

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…The most commonly mentioned medicinal plant species was Swertia chirayita (43 citations, 86% RFC), which was primarily used for the treatment of fever [64,87,92]. This plant is commonly known as a bitter tonic in the traditional medicinal system and is used for the treatment of fever and other ailments [87,133]. The other most cited species were Neopicrorhiza scrophulariiflora (42 citations, 84% RFC), followed by Aconitum laciniatum and Viscum articulatum each with 41 citations (RFC 83%), used for the treatment of multiple disorders [20,65,74,75,78].…”

Section: Relative Frequency Of Citationmentioning

confidence: 99%

Traditional use of medicinal plants in the Chyangthapu-Phalaicha biological sub-corridor, Panchthar District, Kangchenjunga Landscape, Nepal

Bhandari

Gurung

Subedi

et al. 2021

Preprint

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Background: Chyangthapu-Phalaicha located in the northeastern Panchthar District, is a biodiversity hotspot in the Eastern Himalaya. The area is dominated by the Kirat indigenous community. The present study was conducted to document the knowledge of the ethnomedicinal uses and practices that exist in the area before the associated socio-cultural knowledge on biological diversity is lost. Methods: Ethnomedicinal data were collected through semi-structured questionnaires. Stakeholders meetings were organized for assessing the conservation issues in the sub-corridor. The importance of medicinal plant species was assessed using quantitative indices such as informant consensus factor, relative frequency of citation, relative importance, fidelity level and Rahman’s similarity index. Results: Altogether, 140 medicinal plant species from 68 families and 127 genera were reported, which were used to treat 12 health disorders categories. The dominant families were Asteraceae and Fabaceae which contributed eight species each. Fifty-five percent of the total medicinal plant species comprised of herbs. The most frequently used plant parts were underground parts (33%) and leaf (15%). The most common remedies preparation method was extract. Oral administration was the most common therapeutic mode (60%). Maximum informant consensus factor (0.96) was calculated for gastrointestinal disorders. The highest relative frequency of citation and fidelity level was observed for Swertia chirayita (0.83 and 100% respectively). Artemisia dubia depicted the highest relative importance (91.67). A thorough review of previous literature and analysis of field data revealed new therapeutic use reports for 41 ailments associated with 52 plant species. The Rahman similarity index was high with the studies in neighbouring areas, while it was low with the geographically distant studies. Conclusions: The ethnomedicinal study of the Chyangthapu-Phalaicha biological sub-corridor in the Kangchenjunga Landscape indicates that the area supports significant medicinal plants and associated traditional knowledge. The varied use of reported medicinal plants in the area indicates the need for their domestication, processing and phytochemical investigation, especially for those with high ethnobotanical indices.

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“…The most commonly mentioned MP was Swertia chirayita (43 citations, 86% RFC), which was primarily used for the treatment of fever [49,72,83]. This plant is commonly known as a bitter tonic in the traditional medicinal system and is used for the treatment of fever and other ailments [72,109]. The other most cited species were Neopicrorhiza scrophularii ora (42 citations, 84% RFC), followed by Aconitum laciniatum and Viscum album each with 41 citations (RFC 83%), used for the treatment of multiple disorders [21,50,59,60,63].…”

Section: Relative Frequency Of Citationmentioning

confidence: 99%

Traditional use of medicinal plants in the Chyangthapu-Phalaicha biological sub-corridor, Panchthar District, Kangchenjunga Landscape, Nepal

Bhandari

Gurung

Subedi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Chyangthapu-Phalaicha located in the northeastern Panchthar District, is a biodiversity hotspot in the Eastern Himalaya. The area is dominated by the Kirat indigenous community. The present study was conducted to document the knowledge of the ethnomedicinal uses and practices that exist in the area before the associated socio-cultural knowledge on biological diversity is lost. Methods: Ethnomedicinal data were collected through three focus group discussions and 47 key informant interviews using semi-structured questionnaires. The importance of medicinal plant species was assessed using quantitative indices such as informant consensus factor, relative frequency of citation, relative importance, fidelity level and Rahman’s similarity index. Results: Altogether, 140 medicinal plant species from 68 families and 127 genera were reported, which were used to treat 12 diseases categories. The dominant families were Asteraceae and Fabaceae which contributed eight species each. Fifty-five percent of the total medicinal plant species comprised of herbs. The most frequently used plant parts were underground parts (33%) and leaf (15%). The most common remedies preparation method was extract. Oral administration was the most common therapeutic mode (60%). Maximum informant consensus factor (0.96) was calculated for gastrointestinal diseases. The highest relative frequency of citation and fidelity level was observed for Swertia chirayita (0.83 and 100% respectively). Artemisia dubia depicted the highest relative importance (91.67). A thorough review of previous literature and analysis of field data revealed 90 new therapeutic use reports for 42 ailments belonging to 64 plant species.Conclusions: The ethnomedicinal study of the Chyangthapu-Phalaicha biological sub-corridor in the Kangchenjunga Landscape indicates that the area supports significant medicinal plants and associated traditional knowledge. The varied use of reported medicinal plants in the area indicates the need for their cultivation, processing and phytochemical investigation, especially for those with high ethnobotanical indices.

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Review on Swertia Chirata as Traditional Uses to Its Pyhtochemistry and Phrmacological Activity

Cited by 26 publications

References 19 publications

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants

Traditional use of medicinal plants in the Chyangthapu-Phalaicha biological sub-corridor, Panchthar District, Kangchenjunga Landscape, Nepal

Traditional use of medicinal plants in the Chyangthapu-Phalaicha biological sub-corridor, Panchthar District, Kangchenjunga Landscape, Nepal

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